Disease relevance of Metomidate hydrochloride

• Pheochromocytomas, metastases to the adrenal gland, and nonadrenal masses were all MTO negative [1].
• Adverse reactions with metomidate indicated caution when using this drug in chickens; the drug also caused marked bradycardia [2].
• Metomidate rapidly immobilized the fish, with respiratory depression, reduced heart rate, and loss of balance/motor control within 1 min (mean) [3].
• Azaperone and metomidate was associated with marked increases in cardiac and respiration rates and marked hypothermia, which persisted throughout [4].

High impact information on Metomidate hydrochloride

• The addition of metomidate had no effect on Q because an increase in stroke volume (by 30%) compensated for the decrease in heart rate [5].
• Laparotomy and thoractomy were possible with the equithesin/diazepam combination, but only laparotomy was possible with the metomidate/diazepam combination [2].
• Cortisol began to decrease in catfish immediately after the removal of the stress but continued to increase for 15 min in sunshine bass recovering in fresh water and for 5 min in bass recovering in metomidate [6].
• Heart rate (HR), cardiac output (Q), dorsal aortic pressure (DAP) and stroke volume (SV) were measured in minimally disturbed salmon during 5 min anaesthetic inductions with approximately equi-potent concentrations of MS222 (100 ppm), metomidate (6-10 ppm) and AQUI-S (60 ppm) [7].
• Ostrich chicks (n = 34) were successfully immobilised with intramuscular injections of a tiletamine/zolazepam mixture at dosages of 5, 10, 15 and 20 mg kg-1; with metomidate at dosages of 15 and 20 mg kg-1 and with a metomidate/azaperone combination at respectively 20 and 6.6 mg kg-1, and 10 and 3.3 mg kg-1 [8].

Biological context of Metomidate hydrochloride

• Endotracheal intubation for inhalation anaesthesia should, however, be performed after a single injection of metomidate, as thiopentone tended to cause respiratory arrest [9].

Anatomical context of Metomidate hydrochloride

• Furthermore potassium ferricyanide treatment of microsomes does not increase COH after in vivo treatment of mice with eto- and metomidate [10].

Associations of Metomidate hydrochloride with other chemical compounds

• Light surgical anaesthesia lasting 12-15 min was produced by metomidate at 50 mg/kg and by etomidate at 30 mg/kg after intraperitoneal injection [11].
• These data suggest that among several liver microsomal P450 isoenzymes, metyrapone, eto- and metomidate interact preferentially with the P450Coh and that eto- and metomidate may alter selectively the catalytic properties of P450Coh leading to decreased enzyme activity [10].
• Treatment of mice with eto- and metomidate decreases the microsomal COH also in vivo while the other activities remained unchanged (with the exception of 7-ethoxycoumarin O-deethylase (ECDE) in case of metomidate) [10].

Analytical, diagnostic and therapeutic context of Metomidate hydrochloride

• Positron emission tomography (PET) using (11)C-labeled metomidate (MTO) has previously been described as a tool for specific adrenocortical imaging [1].

References