Gene Review:
Ephx1 - epoxide hydrolase 1, microsomal (xenobiotic)
Rattus norvegicus
Synonyms:
Eph-1, Epoxide hydratase, Epoxide hydrolase 1, Microsomal epoxide hydrolase
- Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Fahey, J.W., Zhang, Y., Talalay, P. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Quantiation of epoxide hydrolase released from hyperplastic nodule and hepatoma microsomes. Griffin, M.J., Noda, K. Cancer Res. (1980)
- Transcriptional regulation of rat microsomal epoxide hydrolase gene by imidazole antimycotic agents. Kim, S.G. Mol. Pharmacol. (1992)
- Induction of microsomal epoxide hydrolase by sulfur amino acid deprivation via the pathway of C-Jun N-terminal kinase and its extracellular exposure during cell death. Kang, K.W., Novak, R.F., Lee, C.H., Kim, S.G. Free Radic. Biol. Med. (2002)
- Induction of alkoxyresorufin O-dealkylases, epoxide hydrolase, and liver weight gain: correlation with liver tumor-promoting potential in a series of barbiturates. Nims, R.W., Devor, D.E., Henneman, J.R., Lubet, R.A. Carcinogenesis (1987)
- Antibodies against homogeneous epoxide hydratase provide evidence for a single enzyme hydrating styrene oxide and benz(a)pyrene 4,5-oxide. Oesch, F., Bentley, P. Nature (1976)
- Cytosolic and microsomal epoxide hydrolases: differential properties in mammalian liver. Ota, K., Hammock, B.D. Science (1980)
- Aryl hydrocarbon hydroxylase and epoxide hydratase activities: age effects in mammary epithelial cells of Sprague-Dawley rats. Greiner, J.W., Bryan, A.H., Malan-Shibley, L.B., Janss, D.H. J. Natl. Cancer Inst. (1980)
- Epoxide hydrolase is a marker for the smooth endoplasmic reticulum in rat liver. Galteau, M.M., Antoine, B., Reggio, H. EMBO J. (1985)
- Epoxidation reactions catalyzed by rat liver cytochromes P-450 and P-448 occur at different faces of the 8,9-double bond of 8-methylbenz[a]anthracene. Yang, S.K., Chou, M.W., Fu, P.P., Wislocki, P.G., Lu, A.H. Proc. Natl. Acad. Sci. U.S.A. (1982)
- Induction of rat liver microsomal epoxide hydrolase by thiazole and pyrazine: hydrolysis of 2-cyanoethylene oxide. Kim, S.G., Kedderis, G.L., Batra, R., Novak, R.F. Carcinogenesis (1993)
- Induction of epoxide hydrolase in cultured rat hepatocytes and hepatoma cell lines. Razzouk, C., McManus, M.E., Hayashi, S., Schwartz, D., Thorgeirsson, S.S. Biochem. Pharmacol. (1985)
- Toxicogenomics of bromobenzene hepatotoxicity: a combined transcriptomics and proteomics approach. Heijne, W.H., Stierum, R.H., Slijper, M., van Bladeren, P.J., van Ommen, B. Biochem. Pharmacol. (2003)
- Prevention of c-Jun/activator protein-1 activation and microsomal epoxide hydrolase induction in the rat liver by cysteine during protein-calorie malnutrition. Cho, M.K., Kim, Y.G., Lee, M.G., Kim, S.G. Biochem. Pharmacol. (2001)
- Effects of model traumatic injury on hepatic drug metabolism in the rat. VI. Major detoxification/toxification pathways. Griffeth, L.K., Rosen, G.M., Rauchman, E.J. Drug Metab. Dispos. (1987)
- Structure and organization of the microsomal xenobiotic epoxide hydrolase gene. Falany, C.N., McQuiddy, P., Kasper, C.B. J. Biol. Chem. (1987)
- Complementary DNA and amino acid sequence of rat liver microsomal, xenobiotic epoxide hydrolase. Porter, T.D., Beck, T.W., Kasper, C.B. Arch. Biochem. Biophys. (1986)
- Effect of phenobarbital on the level of translatable rat liver epoxide hydrolase mRNA. Pickett, C.B., Lu, A.Y. Proc. Natl. Acad. Sci. U.S.A. (1981)
- Regulation of microsomal, xenobiotic epoxide hydrolase messenger RNA in persistent hepatocyte nodules and hepatomas induced by chemical carcinogens. Ding, V.D., Cameron, R., Pickett, C.B. Cancer Res. (1990)
- Evaluation of octamethylcyclotetrasiloxane (D4) as an inducer of rat hepatic microsomal cytochrome P450, UDP-glucuronosyltransferase, and epoxide hydrolase: a 28-day inhalation study. McKim, J.M., Wilga, P.C., Kolesar, G.B., Choudhuri, S., Madan, A., Dochterman, L.W., Breen, J.G., Parkinson, A., Mast, R.W., Meeks, R.G. Toxicol. Sci. (1998)
- Metabolic pathways of 7,12-dimethylbenz[a]anthracene in hepatic microsomes. Yang, S.K., Dower, W.V. Proc. Natl. Acad. Sci. U.S.A. (1975)
- Enzymatic conversion of benzo(a)pyrene leading predominantly to the diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene through a single enantiomer of r-7, t-8-dihydroxy-7,8-dihydrobenzo(a)pyrene. Yang, S.K., McCourt, D.W., Roller, P.P., Gelboin, H.V. Proc. Natl. Acad. Sci. U.S.A. (1976)
- Alcohol dehydrogenase-coupled spectrophotometric assay of epoxide hydratase activity. Guengerich, F.P., Mason, P.S. Anal. Biochem. (1980)
- Regional distribution and expression modulation of cytochrome P-450 and epoxide hydrolase mRNAs in the rat brain. Schilter, B., Omiecinski, C.J. Mol. Pharmacol. (1993)
- Comparison of hepatic carcinogen initiation-promotion systems. Leonard, T.B., Dent, J.G., Graichen, M.E., Lyght, O., Popp, J.A. Carcinogenesis (1982)
- Formation of 1,N2- and N2,3-ethenoguanine from 2-halooxiranes: isotopic labeling studies and isolation of a hemiaminal derivative of N2-(2-oxoethyl)guanine. Guengerich, F.P., Persmark, M., Humphreys, W.G. Chem. Res. Toxicol. (1993)
- Tumor necrosis factor alpha blockade increases renal Cyp2c23 expression and slows the progression of renal damage in salt-sensitive hypertension. Elmarakby, A.A., Quigley, J.E., Pollock, D.M., Imig, J.D. Hypertension (2006)
- Multiplicity of induction patterns of rat liver microsomal mono-oxygenases and other polypeptides produced by administration of various xenobiotics. Sharma, R.N., Cameron, R.G., Farber, E., Griffin, M.J., Joly, J.G., Murray, R.K. Biochem. J. (1979)
- Denaturation of cytochrome P-450 by indomethacin and other non-steroidal anti-inflammatory drugs: evidence for a surfactant mechanism and a selective effect of a p-chlorophenyl moiety. Falzon, M., Nielsch, A., Burke, M.D. Biochem. Pharmacol. (1986)
- Endocrine factors modulate the phenobarbital-mediated induction of cytochromes P450 and phase II enzymes in a similar strain-dependent manner. Ganem, L.G., Jefcoate, C.R. Toxicol. Appl. Pharmacol. (1998)
- Metabolism of benzo(a)pyrene by subcellular fractions of rat liver: evidence for similar patterns of cytochrome P-450 in rough and smooth endoplasmic reticulum but not in nuclei and plasma membrane. Oesch, F., Bentley, P., Golan, M., Stasiecki, P. Cancer Res. (1985)
- Regulation of three forms of cytochrome P-450 and epoxide hydrolase in rat liver microsomes. Effects of age, sex, and induction. Thomas, P.E., Reik, L.M., Ryan, D.E., Levin, W. J. Biol. Chem. (1981)
- Studies on the proliferation and fate of oval cells in the liver of rats treated with 2-acetylaminofluorene and partial hepatectomy. Tatematsu, M., Ho, R.H., Kaku, T., Ekem, J.K., Farber, E. Am. J. Pathol. (1984)