Disease relevance of ammonium perchlorate

• A 90-day drinking water toxicity study in rats of the environmental contaminant ammonium perchlorate [1].

High impact information on ammonium perchlorate

• Effects of ammonium perchlorate on thyroid function in developing fathead minnows, Pimephales promelas [2].
• Ammonium perchlorate, used in the solid-propellant of rocket engines, has contaminated some water supplies and represents a potential public health hazard [3].
• Adequate retention, separation, and peak efficiency and symmetry were obtained for most analytes on a 250 x 4.6 mm i.d. column using methanol containing ammonium perchlorate (10 mmol L(-1), pH 6.7 or pH 8.3) as eluent [4].
• On the viscosity of composite suspensions of aluminum and ammonium perchlorate particles dispersed in hydroxyl terminated polybutadiene--New empirical model [5].
• A mixture of ammonium perchlorate and sodium chlorate enhances alterations of the pituitary-thyroid axis caused by the individual chemicals in adult male F344 rats [6].

Chemical compound and disease context of ammonium perchlorate

• The purpose of this study was to evaluate the subchronic toxicity of perchlorate when administered to Sprague-Dawley rats as ammonium perchlorate (AP) for 14 or 90 days [1].

Biological context of ammonium perchlorate

• We believe that ammonium perchlorate may pose a threat to normal development and growth in natural amphibian populations [7].
• Effects of ammonium perchlorate on the reproductive performance and thyroid follicle histology of zebrafish [8].
• Evaluation of a population with occupational exposure to airborne ammonium perchlorate for possible acute or chronic effects on thyroid function [9].
• Ammonium perchlorate significantly inhibited tail resorption after a 14-d exposure in the U.S. Environmental Protection Agency (U.S. EPA) Endocrine Disruptor Screening and Testing Committee (EDSTAC) Tier I frog metamorphosis assay for thyroid disruption in amphibians [7].
• Environmentally relevant concentrations of ammonium perchlorate inhibit thyroid function and alter sex ratios in developing Xenopus laevis [10].

Anatomical context of ammonium perchlorate

• Ammonium perchlorate inhibited forelimb emergence, the percentage of animals completing tail resorption, and hindlimb development during the 70-d exposure period [10].
• In utero and lactational exposure of Long-Evans rats to ammonium perchlorate (AP) disrupts ovarian follicle maturation [11].
• A developmental neurotoxicity study was conducted to generate additional data on the potential functional and morphological hazard to the central nervous system caused by ammonium perchlorate in offspring from in utero and lactation exposure [12].

Associations of ammonium perchlorate with other chemical compounds

• Perchlorate did not affect body or organ weights significantly; however, at 1 mM, AP caused alteration of thyroid gland morphology [13].

Analytical, diagnostic and therapeutic context of ammonium perchlorate

• A portion (100 microL) of the extract was injected onto a Spherisorb S5SCX HPLC column (150 x 4.6 mm i.d.) which was eluted with methanol:water (19 + 1) containing ammonium perchlorate (40 mmol/L), final pH 7 [14].
• After centrifugation, the extract (100 microliters) is analysed using an unmodified silica column (250 x 5 mm ID) and iso-octane-methanol-methyl t-butyl ether (55:25:20) containing ammonium perchlorate (10 mM, pH 5.7) as eluent and with fluorescence detection [15].

References