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Chemical Compound Review

PKHA     azanium perchlorate

Synonyms: HSDB 474, AG-H-12440, AC1L2NKQ, CTK2H7696, UN0402, ...
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Disease relevance of ammonium perchlorate


High impact information on ammonium perchlorate


Chemical compound and disease context of ammonium perchlorate


Biological context of ammonium perchlorate


Anatomical context of ammonium perchlorate


Associations of ammonium perchlorate with other chemical compounds

  • Perchlorate did not affect body or organ weights significantly; however, at 1 mM, AP caused alteration of thyroid gland morphology [13].

Analytical, diagnostic and therapeutic context of ammonium perchlorate

  • A portion (100 microL) of the extract was injected onto a Spherisorb S5SCX HPLC column (150 x 4.6 mm i.d.) which was eluted with methanol:water (19 + 1) containing ammonium perchlorate (40 mmol/L), final pH 7 [14].
  • After centrifugation, the extract (100 microliters) is analysed using an unmodified silica column (250 x 5 mm ID) and iso-octane-methanol-methyl t-butyl ether (55:25:20) containing ammonium perchlorate (10 mM, pH 5.7) as eluent and with fluorescence detection [15].


  1. A 90-day drinking water toxicity study in rats of the environmental contaminant ammonium perchlorate. Siglin, J.C., Mattie, D.R., Dodd, D.E., Hildebrandt, P.K., Baker, W.H. Toxicol. Sci. (2000) [Pubmed]
  2. Effects of ammonium perchlorate on thyroid function in developing fathead minnows, Pimephales promelas. Crane, H.M., Pickford, D.B., Hutchinson, T.H., Brown, J.A. Environ. Health Perspect. (2005) [Pubmed]
  3. Perchlorate and thyroid function: what are the environmental issues? Hershman, J.M. Thyroid (2005) [Pubmed]
  4. Characterization of a microparticulate strong anion-exchanger in the HPLC of acidic drugs. Morgan, P.E., Hanna-Brown, M., Flanagan, R.J. Biomed. Chromatogr. (2006) [Pubmed]
  5. On the viscosity of composite suspensions of aluminum and ammonium perchlorate particles dispersed in hydroxyl terminated polybutadiene--New empirical model. Arefinia, R., Shojaei, A. Journal of colloid and interface science. (2006) [Pubmed]
  6. A mixture of ammonium perchlorate and sodium chlorate enhances alterations of the pituitary-thyroid axis caused by the individual chemicals in adult male F344 rats. Khan, M.A., Fenton, S.E., Swank, A.E., Hester, S.D., Williams, A., Wolf, D.C. Toxicologic pathology. (2005) [Pubmed]
  7. Environmentally relevant concentrations of ammonium perchlorate inhibit development and metamorphosis in Xenopus laevis. Goleman, W.L., Urquidi, L.J., Anderson, T.A., Smith, E.E., Kendall, R.J., Carr, J.A. Environ. Toxicol. Chem. (2002) [Pubmed]
  8. Effects of ammonium perchlorate on the reproductive performance and thyroid follicle histology of zebrafish. Patiño, R., Wainscott, M.R., Cruz-Li, E.I., Balakrishnan, S., McMurry, C., Blazer, V.S., Anderson, T.A. Environ. Toxicol. Chem. (2003) [Pubmed]
  9. Evaluation of a population with occupational exposure to airborne ammonium perchlorate for possible acute or chronic effects on thyroid function. Gibbs, J.P., Ahmad, R., Crump, K.S., Houck, D.P., Leveille, T.S., Findley, J.E., Francis, M. J. Occup. Environ. Med. (1998) [Pubmed]
  10. Environmentally relevant concentrations of ammonium perchlorate inhibit thyroid function and alter sex ratios in developing Xenopus laevis. Goleman, W.L., Carr, J.A., Anderson, T.A. Environ. Toxicol. Chem. (2002) [Pubmed]
  11. In utero and lactational exposure of Long-Evans rats to ammonium perchlorate (AP) disrupts ovarian follicle maturation. Baldridge, M.G., Stahl, R.L., Gerstenberger, S.L., Tripoli, V., Hutz, R.J. Reprod. Toxicol. (2004) [Pubmed]
  12. Refining the effects observed in a developmental neurobehavioral study of ammonium perchlorate administered orally in drinking water to rats. II. Behavioral and neurodevelopment effects. York, R.G., Barnett, J., Girard, M.F., Mattie, D.R., Bekkedal, M.V., Garman, R.H., Strawson, J.S. International journal of toxicology. (2005) [Pubmed]
  13. Evaluation of adult quail and egg production following exposure to perchlorate-treated water. Gentles, A., Surles, J., Smith, E.E. Environ. Toxicol. Chem. (2005) [Pubmed]
  14. HPLC of sertraline and norsertraline in plasma or serum. Patel, J., Spencer, E.P., Flanagan, R.J. Biomed. Chromatogr. (1996) [Pubmed]
  15. Measurement of penbutolol and 4-hydroxypenbutolol in plasma or serum by HPLC. Bhamra, R.K., Flanagan, R.J., Holt, D.W. Biomed. Chromatogr. (1986) [Pubmed]
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