Disease relevance of Beryllium sulphate

• A beryllium (Be)-ferritin adduct containing 270 pm of Be stimulated proliferation of bronchoalveolar lavage (BAL) lymphocytes from subjects with chronic beryllium disease (CBD) at concentrations 5-6 logs lower than the amounts of beryllium sulfate (BeSO4) needed to induce proliferation [1].
• Acute pulmonary toxicity of beryllium sulfate inhalation in rats and mice: cell kinetics and histopathology [2].
• As an approach to develop a murine model reflecting some aspects of sarcoidosis, we attempted to induce berylliosis in mice by treating inbred F1 mice (C57B16 x DBA/2) with 3 mg beryllium sulfate (BeSO4) per kg body weight intraperitoneally [3].
• Experimental pulmonary berylliosis in rabbits sensitized to beryllium sulfate: contact hypersensitivity [4].
• In this study, the mutagenicity of beryllium sulfate (BeSO(4)) and the comutagenicity of beryllium with a known mutagen 1-methyl-3-nitro-1-nitrosoguanidine (MNNG) were evaluated using a forward mutant detection system developed in Escherichia coli [5].

High impact information on Beryllium sulphate

• Using intracellular cytokine staining, we found that the frequency of beryllium-specific CD4(+) T cells in the lungs (bronchoalveolar lavage) of 12 CBD patients ranged from 1.4% to 29% (mean 17.8%), and these T cells expressed a Th1-type phenotype in response to beryllium sulfate (BeSO(4)) [6].
• After in vitro stimulation of BAL T cells with beryllium sulfate and interleukin-2, we noted further alteration of the BAL TCR repertoire in some individuals [7].
• Cell lines were derived from tumors developed in nude mice injected subcutaneously with BALB/c-3T3 cells morphologically transformed with beryllium sulfate [8].
• Gene expression profile in BALB/c-3T3 cells transformed with beryllium sulfate [8].
• The effects of lung injury in rats and mice exposed to an aerosol of beryllium sulfate for 1 hr through nose-only inhalation were evaluated by the method of bronchoalveolar lavage [9].

Chemical compound and disease context of Beryllium sulphate

• Protection by parenteral iron administration against the inhalation toxicity of beryllium sulfate [10].

Anatomical context of Beryllium sulphate

• Effects produced on isolated rat heart mitochondria by beryllium sulfate [11].
• Rabbit alveolar macrophages were exposed in culture medium to asbestos, beryllium sulfate, and beryllium oxide [12].
• General effects of beryllium sulfate on isolated rat heart muscle mitochondrial fraction [13].
• In contrast, mitogen-stimulated (phytohemagglutinin, concanavalin A, pokeweed mitogen) and antigen-stimulated (purified protein derivative, beryllium sulfate) mononuclear cells (stimulation index greater than 5) inhibited log phase fibroblast growth [14].
• Mitogenic effect of beryllium sulfate on mouse B lymphocytes but not T lymphocytes in vitro [15].

Associations of Beryllium sulphate with other chemical compounds

• These carcinogenic properties are associated with mutagenic activity as shown by the results of short-term tests performed in vitro with beryllium chloride and beryllium sulfate [16].
• Pulmonary alveolar macrophage cells (PAM), obtained by bronchopulmonary lavage of Beagle dogs, were exposed in vitro to beryllium oxide (BeO) particles calcined at either 500 or 1000 degrees C or to beryllium sulfate (BeSO4) [17].

Analytical, diagnostic and therapeutic context of Beryllium sulphate

• All three CBD patients studied had a positive response to beryllium sulfate application and a negative patch test to normal saline [18].

References