Disease relevance of terbutaline

• In conclusion, Bricanyl Turbuhaler (0.5 mg) and Ventolin Rotahaler (0.4 mg) were equally efficacious in the treatment of exercise-induced asthma in children [1].
• In a double-blind cross-over study the effect of terbutaline spray (Bricanyl aerosol) inhalations was tested in 14 women with severe dysmenorrhea [2].
• Terbutaline (Bricanyl) in the treatment of female urge incontinence [3].
• The effects of oral treatment with terbutaline sustained-release (SR) tablets (Bricanyl Depot) were studied in nine patients who had bronchial asthma and marked diurnal variation in ventilatory function [4].
• Terbutaline has been determined in milk and plasma from 4 nursing mothers treated with Bricanyl tablets (2.5 or 5 mg, 3 times daily) because of obstructive lung disease [5].

High impact information on terbutaline

• RESULTS--The mean (SD) urinary excretion of salbutamol 30 minutes after inhalation using the MDI alone and with the Volumatic, Bricanyl Spacer, Nebuhaler, and open mouth technique was 2.83 (0.78)%, 3.37 (0.69)%, 4.09 (0.91)%, 4.34 (1.60)%, and 3.49 (0.98)%, respectively, expressed as a percentage of the nominal dose [6].
• An ATOMISOR NL9 M jet nebulizer (La Diffusion Technique Francaise, France) was filled with terbutaline (Bricanyl, Astra-Zeneca, Sweden) and connected to the inspiratory line of a Horus ventilator (Taema, France) [7].
• This randomized, double-blind, crossover study in two parts compared tolerability to high doses of formoterol (Oxis Turbuhaler) with that of high doses of terbutaline (Bricanyl Turbuhaler) [8].
• CONCLUSION: Both Bricanyl Turbuhaler and Ventolin Rotahaler seem to be effective and well tolerated in the treatment of asthma in preschool children [9].
• The steady-state concentration of TS was relatively consistent and the bioavailability was approximately 50% higher in pH 5 formulations than pH 10 [10].

Biological context of terbutaline

• There were consistent increases in PEFR and FEV1 at the start and end of the study on using the 'Bricanyl Turbohaler'. Over 80% of patients used it correctly in every respect fulfilling each of 8 criteria and 96% found it easy to use [11].
• The effect of bricanyl on placental circulation in late toxaemia of pregnancy [12].
• Greater changes in RL than in AD5 after PL (bronchoconstriction) or TS (bronchodilation) suggest a greater sensitivity of RL than AD5 to airway patency in the large airways [13].

Anatomical context of terbutaline

• Scopolamine (Scopyl)-terbutaline (Bricanyl) almost abolished the propulsive pressure waves in healthy subjects and all patients in the lower 2/3 of the esophagus [14].
• Terbutaline sulfate (Brethine) is a beta-adrenergic agonist that works on smooth muscle [15].
• Subcellar localization of ionic Ca was investigated by the Pb-acetate cytochemical method in rat myometrium on the 21st day of pregnancy, following oxytocin and Bricanyl treatment [16].

Associations of terbutaline with other chemical compounds

• The aim of this study was to compare bronchodilator response and adverse effects of terbutaline when administered with the metered dose inhaler (MDI) Bricanyl and with the dry powder inhaler Bricanyl Turbuhaler (BT) [17].
• To establish suitable test aerosols, two brands of metered dose inhalers containing bronchodilator (Brethaire, Proventil) were radiolabeled with technetium ( 99mTc) and tested to determine if the distribution of radioisotope in the aerosol was representative of the distribution of agonist activity [18].

Analytical, diagnostic and therapeutic context of terbutaline

• Sustained release of the model drug, terbutaline sulphate (TS), from the microspheres was found to be proportional to drug loading and phospholipid content [19].
• The in vitro radiolabel validation was performed to determine whether TBS radiolabeled in this way would be representative of the commercially available product Bricanyl Turbuhaler during clinical trials [20].

References