Disease relevance of Asthma, Exercise-Induced

• We evaluated the effectiveness of different doses of nebulized Sch 1000 (40 microgram and 80 microgram) aerosolized atropine sulfate (1 mg) and placebo in the prevention of exercise-induced bronchospasm (EIB) in 20 children with atopic bronchial asthma [1].
• Ca2+ entry blockers such as nifedipine and verapamil may affect exercise-induced asthma, airway tone, mast cell mediator release, and experimental anaphylaxis [2].
• The ability of the new generation H1-receptor antagonist, astemizole, to prevent histamine-induced airway obstruction and exercise-induced asthma (EIA) was studied in 20 children with asthma [3].
• 1. The effects of a specific PAF acether antagonist (BN 52063) on the response to isocapnic hyperventilation with dry cold air (ISH study) and exercise (EIA study) were assessed in a single dose and short term treatment study in 10 patients with exercise induced asthma [4].
• In conclusion, intranasal albuterol may offer an alternative to metered-dose inhalers for the treatment of acute bronchospasm and for prevention of exercise-induced asthma, especially for children and the elderly [5].

High impact information on Asthma, Exercise-Induced

• Effect of long-term salmeterol treatment on exercise-induced asthma [6].
• CONCLUSIONS: As compared with placebo, once-daily treatment with montelukast provided significant protection against exercise-induced asthma over a 12-week period [7].
• Preventing bronchoconstriction in exercise-induced asthma with inhaled heparin [8].
• The relative effectiveness of ephedrine, theophylline, and hydroxyzine hydrochloride and their combinations was studied in a two-part investigation of 16 youths who has asthma and exercise-induced asthma [9].
• A critical assessment of the mechanism by which hyperoxia attenuates exercise-induced asthma [10].

Chemical compound and disease context of Asthma, Exercise-Induced

• Since the release of such mediators has been implicated in exercise-induced asthma, we investigated whether inhaled heparin could also attenuate the bronchoconstrictor response in this disease [8].
• A critical assessment of the roles of circulating hydrogen ion and lactate in the production of exercise-induced asthma [11].
• Exercise induced asthma: the protective role of CO2 during swimming [12].
• Letter: Aspirin in exercise-induced asthma [13].
• Protection against exercise-induced asthma with this drug has been variable, but ipratropium has been found particularly useful in psychogenic asthma [14].

Biological context of Asthma, Exercise-Induced

• Inhalation of heparin, an anticoagulant, attenuates exercise- induced asthma (EIA) in human subjects [15].
• This indicated that none of these trained athletes demonstrated exercise-induced asthma and that there was no difference in airway resistance after maximal exercise while they were under the influence of theophylline or placebo [16].
• Reduction of exercise-induced asthma oxidative stress by lycopene, a natural antioxidant [17].
• Tachyphylaxis following regular use of formoterol in exercise-induced bronchospasm [18].

Anatomical context of Asthma, Exercise-Induced

• OBJECTIVE: We compared the incidence of late asthmatic response, the changes in airway responsiveness, the degree of epithelial desquamation, and the activation of eosinophils in the airways after induction of allergen-induced asthma and exercise-induced asthma [19].
• Comparison between allergen-induced and exercise-induced asthma with respect to the late asthmatic response, airway responsiveness, and Creola bodies in sputum [19].
• Neutrophil chemotactic activity and histamine in atopic and nonatopic subjects after exercise-induced asthma [20].
• Inhaled salbutamol was less effective in protecting against exercise-induced asthma at the end of the treatment period in the patients who had received tablet therapy, but otherwise there was no significant change in beta-receptor function of either airways or lymphocytes [21].
• To investigate the possibility that stimulation of neural receptors in the posterior pharynx plays a role in the pathogenesis of exercise-induced asthma, we had 10 asthmatic subjects simulate the hyperpnea of exercise by performing eucapnic hypervenilation in the presence and absence of oropharyngeal anesthesia induced by lidocaine [22].

Gene context of Asthma, Exercise-Induced

• In particular, they possibly provide novel insights into the molecular mechanisms of exercise-induced bronchoconstriction and suggest that enhanced transcription of ALOX5 and its activating protein together with a present predisposition of the subject critically contribute to exercise-induced asthma [23].
• Effect of body mass on exercise-induced bronchospasm and atopy in African children [24].
• Comparison of aerosolized atropine sulfate and SCH 1000 on exercise-induced bronchospasm in children [1].
• In this study, we have measured HS NCA and HL NCA after exercise of 22 adult patients with asthma, 13 of whom had exercise-induced asthma (EIA) [25].
• The leukotriene C4 synthase (A-444C) promoter polymorphism is associated with the severity of exercise-induced asthma in Korean children [26].

Analytical, diagnostic and therapeutic context of Asthma, Exercise-Induced

• Albuterol or placebo (180 micrograms) were administered by metered-dose inhaler 20 minutes before a 10-minute exposure to SO2 or clean air during moderate exercise on a treadmill at an exercise level that by itself did not produce exercise-induced bronchospasm [27].
• In summary, no significant change in peripheral blood prostaglandin E and F2alpha levels as determined by radioimmunoassay was noted at the time of exercise-induced bronchospasm [28].
• To investigate the mechanisms contributing to refractoriness in exercise induced asthma a methacholine challenge test was performed 30 minutes before and 30 minutes after two exercise tests 45 minutes apart [29].
• A placebo-controlled, randomized, double-blind, two-period crossover study was performed to investigate the safety and efficacy of roflumilast in 16 patients with exercise-induced asthma [30].
• In the cross-sectional study, mirth-triggered asthma was more common: with increasing age (P = 0.02); in those who in the last 3 months had taken more doses of salbutamol (P = 0.005), and who had more wheeze, nocturnal symptoms, and early morning symptoms (P < 0.0005); and in those who reported exercise-induced asthma (P < 0.0005) [31].

References