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Chemical Compound Review

ACMC-1CB1H     2-butoxyethanoic acid

Synonyms: CCRIS 7195, QC-411, AG-E-76336, ANW-25645, NSC-10980, ...
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Disease relevance of NSC 10980


High impact information on NSC 10980


Biological context of NSC 10980


Anatomical context of NSC 10980

  • Further, in vitro incubation of blood obtained from BE-pretreated/recovered with the hematotoxic metabolite of BE, 2-butoxyacetic acid (BAA), revealed that erythrocytes obtained from these rats were significantly less sensitive to BAA than those obtained from normal rats [11].

Associations of NSC 10980 with other chemical compounds


Analytical, diagnostic and therapeutic context of NSC 10980


  1. Effects of dose, age, inhibition of metabolism and elimination on the toxicokinetics of 2-butoxyethanol and its metabolites. Ghanayem, B.I., Sanders, J.M., Clark, A.M., Bailer, J., Matthews, H.B. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
  2. In vitro sub-hemolytic effects of butoxyacetic acid on human and rat erythrocytes. Udden, M.M. Toxicol. Sci. (2002) [Pubmed]
  3. New methods for determination of 2-butoxyethanol, butoxyacetaldehyde and butoxyacetic acid in aqueous systems, with special reference to cell culture conditions. Hildenbrand, S., Gfrörer, W., Schmahl, F.W., Dartsch, P.C. Arch. Toxicol. (2000) [Pubmed]
  4. Hemodialysis following butoxyethanol ingestion. Burkhart, K.K., Donovan, J.W. J. Toxicol. Clin. Toxicol. (1998) [Pubmed]
  5. Hemolysis and deformability of erythrocytes exposed to butoxyacetic acid, a metabolite of 2-butoxyethanol: II. Resistance in red blood cells from humans with potential susceptibility. Udden, M.M. Journal of applied toxicology : JAT. (1994) [Pubmed]
  6. Mechanisms of 2-butoxyethanol-induced hemangiosarcomas. Corthals, S.M., Kamendulis, L.M., Klaunig, J.E. Toxicol. Sci. (2006) [Pubmed]
  7. Mechanisms of 2-butoxyethanol carcinogenicity: studies on Syrian Hamster Embryo (SHE) cell transformation. Park, J., Kamendulis, L.M., Klaunig, J.E. Toxicol. Sci. (2002) [Pubmed]
  8. Physiologically based pharmacokinetics of 2-butoxyethanol and its major metabolite, 2-butoxyacetic acid, in rats and humans. Corley, R.A., Bormett, G.A., Ghanayem, B.I. Toxicol. Appl. Pharmacol. (1994) [Pubmed]
  9. A human exposure study to investigate biological monitoring methods for 2-butoxyethanol. Jones, K., Cocker, J. Biomarkers (2003) [Pubmed]
  10. Comparison of the acute hematotoxicity of 2-butoxyethanol in male and female F344 rats. Ghanayem, B.I., Ward, S.M., Chanas, B., Nyska, A. Human & experimental toxicology. (2000) [Pubmed]
  11. Development of tolerance to 2-butoxyethanol-induced hemolytic anemia and studies to elucidate the underlying mechanisms. Ghanayem, B.I., Sanchez, I.M., Matthews, H.B. Toxicol. Appl. Pharmacol. (1992) [Pubmed]
  12. Effect of age on the toxicity and metabolism of ethylene glycol monobutyl ether (2-butoxyethanol) in rats. Ghanayem, B.I., Blair, P.C., Thompson, M.B., Maronpot, R.R., Matthews, H.B. Toxicol. Appl. Pharmacol. (1987) [Pubmed]
  13. Biomonitoring of technical grade 1-alkoxy-2-propanol acetates by analysing urinary 2-alkoxypropionic acids. Laitinen, J. Sci. Total Environ. (1997) [Pubmed]
  14. Synthesis, characterization, and use of 2-[(2H(9))butoxy]acetic acid and 2-(3-methylbutoxy)acetic acid as an internal standard and an instrument performance surrogate, respectively, for the gas chromatographic-mass spectrometric determination of 2-butoxyacetic acid, a human metabolite of 2-butoxyethanol. Brown, K.K., Cheever, K.L., Butler, M.A., Shaw, P.B., McLaurin, J.L. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2003) [Pubmed]
  15. Metabolism and disposition of ethylene glycol monobutyl ether (2-butoxyethanol) in rats. Ghanayem, B.I., Burka, L.T., Sanders, J.M., Matthews, H.B. Drug Metab. Dispos. (1987) [Pubmed]
  16. Percutaneous absorption of 2-butoxyethanol in man. Johanson, G., Boman, A., Dynésius, B. Scandinavian journal of work, environment & health. (1988) [Pubmed]
  17. Free and total urinary 2-butoxyacetic acid following dermal and inhalation exposure to 2-butoxyethanol in human volunteers. Kezic, S., Meuling, W.J., Jakasa, I. International archives of occupational and environmental health. (2004) [Pubmed]
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