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Chemical Compound Review

Butylglycol     2-butoxyethanol

Synonyms: EGMBE, BUCS, EGBE, Butoxyethanol, Butylcelosolv, ...
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Disease relevance of Ethylene glycol butyl ether


High impact information on Ethylene glycol butyl ether


Chemical compound and disease context of Ethylene glycol butyl ether


Biological context of Ethylene glycol butyl ether

  • This toxic effect, coupled with the observation that continued treatment with 2-butoxyethanol results in hemosiderin deposition in the liver, has led to our hypothesis that liver carcinogenicity by 2-butoxyethnaol is mediated via oxidative stress (iron catalyzed) and Kupffer cell activation [11].
  • An increase in hemolysis (measured by a decrease in hematocrit and increase in relative spleen weight) was observed in 2-butoxyethanol-treated rats and mice in a dose-dependent manner [12].
  • These data demonstrate that 2-butoxyethanol and related metabolites do not directly cause DNA damage [3].
  • No apparent differences in apoptosis and mitosis in the liver were observed in mouse and rat liver between 2-butoxyethanol treatment groups and untreated controls [12].
  • Chronic inhalation studies with 2-butoxyethanol (BE) conducted by the National Toxicology Program identified the forestomach and liver of B6C3F1 mice as target organs for tumorigenicity (NTP, 2000) [13].

Anatomical context of Ethylene glycol butyl ether


Associations of Ethylene glycol butyl ether with other chemical compounds


Gene context of Ethylene glycol butyl ether


Analytical, diagnostic and therapeutic context of Ethylene glycol butyl ether


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  2. Comparative inhalation teratogenicity of four glycol ether solvents and an amino derivative in rats. Nelson, B.K., Setzer, J.V., Brightwell, W.S., Mathinos, P.R., Kuczuk, M.H., Weaver, T.E., Goad, P.T. Environ. Health Perspect. (1984) [Pubmed]
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  4. Osteonecrosis in a chemically induced rat model of human hemolytic disorders associated with thrombosis--a new model for avascular necrosis of bone. Shabat, S., Nyska, A., Long, P.H., Goelman, G., Abramovitch, R., Ezov, N., Levin-Harrus, T., Peddada, S., Redlich, M., Yedgar, S., Nyska, M. Calcif. Tissue Int. (2004) [Pubmed]
  5. Review of studies concerning the tumorigenicity of 2-butoxyethanol in B6C3F1 mice and its relevance for human risk assessment. Boatman, R., Corley, R., Green, T., Klaunig, J., Udden, M. Journal of toxicology and environmental health. Part B, Critical reviews. (2004) [Pubmed]
  6. Alteration in methyl-methanesulfonate-induced poly(ADP-ribosyl)ation by 2-butoxyethanol in Syrian hamster embryo cells. Hoflack, J.C., Durand, M.J., Poirier, G.G., Maul, A., Vasseur, P. Carcinogenesis (1997) [Pubmed]
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  8. Eruptive cherry angiomas and irritant symptoms after one acute exposure to the glycol ether solvent 2-butoxyethanol. Raymond, L.W., Williford, L.S., Burke, W.A. J. Occup. Environ. Med. (1998) [Pubmed]
  9. A numerical procedure for choosing effective, low toxicity plasticizers for glycol methacrylate embedding. Gerrits, P.O., Horobin, R.W., Hardonk, M.J. Histochem. J. (1990) [Pubmed]
  10. Association of liver hemangiosarcoma and secondary iron overload in B6C3F1 mice--the National Toxicology Program experience. Nyska, A., Haseman, J.K., Kohen, R., Maronpot, R.R. Toxicologic pathology. (2004) [Pubmed]
  11. Mechanisms of 2-butoxyethanol carcinogenicity: studies on Syrian Hamster Embryo (SHE) cell transformation. Park, J., Kamendulis, L.M., Klaunig, J.E. Toxicol. Sci. (2002) [Pubmed]
  12. Hepatic effects of 2-butoxyethanol in rodents. Siesky, A.M., Kamendulis, L.M., Klaunig, J.E. Toxicol. Sci. (2002) [Pubmed]
  13. Mode of action and pharmacokinetic studies of 2-butoxyethanol in the mouse with an emphasis on forestomach dosimetry. Poet, T.S., Soelberg, J.J., Weitz, K.K., Mast, T.J., Miller, R.A., Thrall, B.D., Corley, R.A. Toxicol. Sci. (2003) [Pubmed]
  14. Effect of exposure concentration on the disposition of inhaled butoxyethanol by F344 rats. Sabourin, P.J., Medinsky, M.A., Birnbaum, L.S., Griffith, W.C., Henderson, R.F. Toxicol. Appl. Pharmacol. (1992) [Pubmed]
  15. Review of the genotoxicity of 2-butoxyethanol. Elliott, B.M., Ashby, J. Mutat. Res. (1997) [Pubmed]
  16. Mutagenicity and cytotoxicity of 2-butoxyethanol and its metabolite, 2-butoxyacetaldehyde, in Chinese hamster ovary (CHO-AS52) cells. Chiewchanwit, T., Au, W.W. Mutat. Res. (1995) [Pubmed]
  17. Immunohistochemical antigen demonstration in plastic-embedded lymphoid tissue. van Goor, H., Harms, G., Gerrits, P.O., Kroese, F.G., Poppema, S., Grond, J. J. Histochem. Cytochem. (1988) [Pubmed]
  18. A simple, rapid method of nucleic acid extraction without tissue homogenization for detecting viroids by hybridization and RT-PCR. Nakahara, K., Hataya, T., Uyeda, I. J. Virol. Methods (1999) [Pubmed]
  19. Toxicokinetics of inhaled 2-butoxyethanol (ethylene glycol monobutyl ether) in man. Johanson, G., Kronborg, H., Näslund, P.H., Byfält Nordqvist, M. Scandinavian journal of work, environment & health. (1986) [Pubmed]
  20. Ocular expression of vascular cell adhesion molecule (VCAM-1) in 2-butoxyethanol-induced hemolysis and thrombosis in female rats. Nyska, A., Moomaw, C.R., Ezov, N., Shabat, S., Levin-Harrus, T., Nyska, M., Redlich, M., Mittelman, M., Yedgar, S., Foley, J.F. Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie. (2003) [Pubmed]
  21. Butoxyethanol ingestion with prolonged hyperchloremic metabolic acidosis treated with ethanol therapy. McKinney, P.E., Palmer, R.B., Blackwell, W., Benson, B.E. J. Toxicol. Clin. Toxicol. (2000) [Pubmed]
  22. The development of forestomach tumours in the mouse following exposure to 2-butoxyethanol by inhalation: studies on the mode of action and relevance to humans. Green, T., Toghill, A., Lee, R., Moore, R., Foster, J. Toxicology (2002) [Pubmed]
  23. Mode of action of butoxyethanol-induced mouse liver hemangiosarcomas and hepatocellular carcinomas. Klaunig, J.E., Kamendulis, L.M. Toxicol. Lett. (2005) [Pubmed]
  24. Correspondence between occupational exposure limit and biological action level values for alkoxyethanols and their acetates. Laitinen, J. International archives of occupational and environmental health. (1998) [Pubmed]
  25. Physiologically based pharmacokinetics of 2-butoxyethanol and its major metabolite, 2-butoxyacetic acid, in rats and humans. Corley, R.A., Bormett, G.A., Ghanayem, B.I. Toxicol. Appl. Pharmacol. (1994) [Pubmed]
  26. Hemodialysis following butoxyethanol ingestion. Burkhart, K.K., Donovan, J.W. J. Toxicol. Clin. Toxicol. (1998) [Pubmed]
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