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Chemical Compound Review

AC1LAAHS     2-amino-9-[[(1S,2S)-1,2...

Synonyms: CHEMBL285442, AG-J-17342, SureCN4550680, CTK7J7049, ZINC00007126
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Disease relevance of A-5021


High impact information on A-5021


Analytical, diagnostic and therapeutic context of A-5021

  • These results indicate that A-5021 has potent cytotoxic activity as a nucleoside analog for gene therapy using HSV-TK gene, and can be used much more safely than GCV [2].


  1. Antiviral agents active against human herpesviruses HHV-6, HHV-7 and HHV-8. De Clercq, E., Naesens, L., De Bolle, L., Schols, D., Zhang, Y., Neyts, J. Rev. Med. Virol. (2001) [Pubmed]
  2. Avoidance of bone marrow suppression using A-5021 as a nucleoside analog for retrovirus-mediated herpes simplex virus type I thymidine kinase gene therapy. Hasegawa, Y., Nishiyama, Y., Imaizumi, K., Ono, N., Kinoshita, T., Hatano, S., Saito, H., Shimokata, K. Cancer Gene Ther. (2000) [Pubmed]
  3. Acyclic/carbocyclic guanosine analogues as anti-herpesvirus agents. De Clercq, E., Andrei, G., Snoeck, R., De Bolle, L., Naesens, L., Degrève, B., Balzarini, J., Zhang, Y., Schols, D., Leyssen, P., Ying, C., Neyts, J. Nucleosides Nucleotides Nucleic Acids (2001) [Pubmed]
  4. The anti-herpesvirus activity of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl)-cycloprop-1'-yl]methyl]guanine is markedly potentiated by the immunosuppressive agent mycophenolate mofetil. Neyts, J., De Clercq, E. Antiviral Res. (2001) [Pubmed]
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