Chemical Compound Review:
Brivudin 5-[(E)-2-bromoethenyl]-1- [(2R,4S,5R)-4...
Synonyms:
BrVdUrd, Brivudina, Brivudine, Brivudinum, Helpin, ...
- High efficiency latency and activation of herpes simplex virus in human cells. Wigdahl, B.L., Scheck, A.C., De Clercq, E., Rapp, F. Science (1982)
- Inhibition of induced chemoresistance by cotreatment with (E)-5-(2-bromovinyl)-2'-deoxyuridine (RP101). Fahrig, R., Heinrich, J.C., Nickel, B., Wilfert, F., Leisser, C., Krupitza, G., Praha, C., Sonntag, D., Fiedler, B., Scherthan, H., Ernst, H. Cancer Res. (2003)
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- Modified polynucleotides. VI. Properties of a synthetic DNA containing the anti-herpes agent (E)-5-(2-bromovinyl)-2'-deoxyuridine. Sági, J., Czuppon, A., Kajtár, M., Szabolcs, A., Szemzö, A., Otvös, L. Nucleic Acids Res. (1982)
- Characterization of herpes simplex virus type 1 thymidine kinase mutants selected under a single round of high-dose brivudin. Andrei, G., Balzarini, J., Fiten, P., De Clercq, E., Opdenakker, G., Snoeck, R. J. Virol. (2005)
- Herpes simplex virus latency in isolated human neurons. Wigdahl, B., Smith, C.A., Traglia, H.M., Rapp, F. Proc. Natl. Acad. Sci. U.S.A. (1984)
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- Specific recognition of the bicyclic pyrimidine nucleoside analogs, a new class of highly potent and selective inhibitors of varicella-zoster virus (VZV), by the VZV-encoded thymidine kinase. Sienaert, R., Naesens, L., Brancale, A., De Clercq, E., McGuigan, C., Balzarini, J. Mol. Pharmacol. (2002)
- Bystander effects of cancer cell lines transduced with the multisubstrate deoxyribonucleoside kinase of Drosophila melanogaster and synergistic enhancement by hydroxyurea. Zheng, X., Johansson, M., Karlsson, A. Mol. Pharmacol. (2001)
- Potential of Varicella zoster virus thymidine kinase as a suicide gene in breast cancer cells. Grignet-Debrus, C., Calberg-Bacq, C.M. Gene Ther. (1997)
- Differential phosphorylation of (E)-5-(2-bromovinyl)-2'-deoxyuridine monophosphate by thymidylate kinases from herpes simplex viruses types 1 and 2 and varicella zoster virus. Fyfe, J.A. Mol. Pharmacol. (1982)
- Brivudin (bromovinyl deoxyuridine). Keam, S.J., Chapman, T.M., Figgitt, D.P. Drugs (2004)
- (E)-5-(2-bromovinyl)-2'-Deoxyuridine in the treatment of experimental herpes simplex keratitis. Maudgal, P.C., De Clercq, E., Descamps, J., Missotten, L., De Somer, P., Busson, R., Vanderhaeghe, H., Verhelst, G., Walker, R.T., Jones, A.S. Antimicrob. Agents Chemother. (1980)
- 5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication. Wigerinck, P., Pannecouque, C., Snoeck, R., Claes, P., De Clercq, E., Herdewijn, P. J. Med. Chem. (1991)
- Enhancing effect of bromovinyldeoxyuridine on antitumor activity of 5'-deoxy-5-fluorouridine against adenocarcinoma 755 in mice. Correlation with pharmacokinetics of plasma 5-fluorouracil levels. Iigo, M., Nishikata, K., Nakajima, Y., Hoshi, A., Okudaira, N., Odagiri, H., De Clercq, E. Biochem. Pharmacol. (1989)
- Altered thymidine-thymidylate kinases from strains of herpes simplex virus with modified drug sensitivities to acyclovir and (E)-5-(2-bromovinyl)-2'-deoxyuridine. Fyfe, J.A., McKee, S.A., Keller, P.M. Mol. Pharmacol. (1983)
- Apoptosis induced by (E)-5-(2-bromovinyl)-2'-deoxyuridine in varicella zoster virus thymidine kinase-expressing cells is driven by activation of c-Jun/activator protein-1 and Fas ligand/caspase-8. Tomicic, M.T., Friedrichs, C., Christmann, M., Wutzler, P., Thust, R., Kaina, B. Mol. Pharmacol. (2003)
- Kinetics of the interaction of monophosphates of the antiviral nucleosides 2'-fluoro-1-beta-D-arabinofuranosylpyrimidine and (E)-5-(2-bromovinyl)-2'-deoxyuridine with thymidylate kinases from Vero cells and herpes simplex virus types 1 and 2. Chen, M.S., Amico, L.A., Speelman, D.J. Antimicrob. Agents Chemother. (1984)
- Use of a herpes thymidine kinase/neomycin phosphotransferase chimeric gene for metabolic suicide gene transfer. Candotti, F., Agbaria, R., Mullen, C.A., Touraine, R., Balzarini, J., Johns, D.G., Blaese, R.M. Cancer Gene Ther. (2000)
- Activation of latent herpes simplex virus type 2 infection in vitro requires a (E)-5-(2-bromovinyl)-2'-deoxyuridine-sensitive gene function. Scheck, A.C., Wigdahl, B., Rapp, F. Intervirology (1987)
- Comparative metabolism of E-5-(2-bromovinyl)-2'-deoxyuridine and 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil in herpes simplex virus-infected cells. Ayisi, N.K., Wall, R.A., Wanklin, R.J., Machida, H., De Clercq, E., Sacks, S.L. Mol. Pharmacol. (1987)
- Phosphorolysis of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and other 5-substituted-2'-deoxyuridines by purified human thymidine phosphorylase and intact blood platelets. Desgranges, C., Razaka, G., Rabaud, M., Bricaud, H., Balzarini, J., De Clercq, E. Biochem. Pharmacol. (1983)
- Bicyclic pyrimidine nucleoside analogues (BCNAs) as highly selective and potent inhibitors of varicella-zoster virus replication. Balzarini, J., McGuigan, C. J. Antimicrob. Chemother. (2002)
- Comparison of four methods for typing low-passage herpes simplex virus isolates. Mayo, D., Hilliard, J., Landry, M., Egbertson, S., Mirkovic, R. Intervirology (1985)
- Influence of (E)-5-(2-bromovinyl)-2'-deoxyuridine on corneal epithelium healing. Maudgal, P.C., De Kimpe, N., De Clercq, E., Descamps, J., Missotten, L., Geysen, A. Graefes Arch. Clin. Exp. Ophthalmol. (1982)
- Application of micellar electrokinetic chromatography for analyzing antiviral drugs in pharmaceutical semisolid formulations. Neubert, R.H., Mrestani, Y., Schwarz, M., Colin, B. Journal of pharmaceutical and biomedical analysis. (1998)
- NB1011 induces Ser15 phosphorylation of p53 and activates the G2/M checkpoint. Dellinger, R.W., Karjian, P.L., Neuteboom, S.T. Anticancer Drugs (2003)
- Cytosolic and mitochondrial deoxyribonucleotidases: activity with substrate analogs, inhibitors and implications for therapy. Mazzon, C., Rampazzo, C., Scaini, M.C., Gallinaro, L., Karlsson, A., Meier, C., Balzarini, J., Reichard, P., Bianchi, V. Biochem. Pharmacol. (2003)
- Diagnosis and evaluation of adults with attention-deficit/hyperactivity disorder. Adler, L., Cohen, J. Psychiatr. Clin. North Am. (2004)
- Highly selective cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine derivatives for murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 thymidine kinase gene. Balzarini, J., De Clercq, E., Verbruggen, A., Ayusawa, D., Seno, T. Mol. Pharmacol. (1985)
- (E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent. De Clercq, E., Descamps, J., De Somer, P., Barr, P.J., Jones, A.S., Walker, R.T. Proc. Natl. Acad. Sci. U.S.A. (1979)
- Susceptibility of recent clinical isolates of herpes simplex virus to 5-ethyl-2'-deoxyuridine: preferential inhibition of herpes simplex virus type 2. Teh, C.Z., Sacks, S.L. Antimicrob. Agents Chemother. (1983)
- Improvement of the bioavailability of the anti-herpes virus agent BVDU by use of 5'-O-alkoxycarbonyl derivatives with increased metabolic stability. Boyd, M.R., Cole, M., Harnden, M.R., Luk, K., Rush, M.A., Sutton, D., Hodge, R.A. J. Antimicrob. Chemother. (1986)
- Incidence of herpes simplex virus types 1 and 2 in penile lesions of college men. Docherty, J.J., Lohse, M.A., Dellaria, M.F., Naugle, F.P., Mason, C.W., Knerr, R.A., McDermott, H.M., Mundon, F.K., Zimmerman, D.H. J. Med. Virol. (1984)
- Linear Darier disease with herpes zoster superinfection treated successfully by brivudine. Abraham, S., Jones, A., Toutous-Trellu, L., Kerl-Bullani, K., Chavaz, P., Saurat, J.H., Piguet, V. Br. J. Dermatol. (2006)