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Chemical Compound Review

Fortimicin     2-amino-N- [(1S,2R,3R,4S,5S,6R)-4-amino- 3...

Synonyms: Fortimicin A, Abbott-44747, XK-701, Abbott 44747, AC1L1BCG, ...
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Disease relevance of XK 70-1


High impact information on XK 70-1


Chemical compound and disease context of XK 70-1


Biological context of XK 70-1

  • The cloning of armA into a plasmid in Escherichia coli conferred to the new host high-level resistance to 4,6-disubstituted deoxystreptamines and fortimicin [12].
  • DNA regions homologous to fms genes were found in Micromonospora sp. SF-2098 and Dactylosporangium matsuzakiense, both producers of fortimicin group antibiotics [13].
  • The key intermediate, 1,2',6'-tri-N-benzyloxycarbonylfortimicin B, was prepared either directly from fortimicin B or by converting fortimicin A into 1,2',6',2''-tetra-N-benzyloxycarbonylfortimicin A (6a), followed by selective hydrolysis of the 4-N-(N-benzyloxycarbonyl)glycyl group of the latter [14].
  • Simultaneous analysis of the serum and urinary pharmacokinetics of fortimicin A after intravenous administration to healthy subjects [15].
  • One pattern exhibited broad substrate specificity including significant activity to fortimicin and was specific for Mycobacterium fortuitum strains, whereas the second pattern showed a much narrower substrate range and was observed for the other 3 environmental species [16].

Associations of XK 70-1 with other chemical compounds


Gene context of XK 70-1


  1. Synergistic activities of fortimicin A and beta-lactam antibiotics against Pseudomonas aeruginosa. Yamashita, K., Kawabe, H., Mitsuhashi, S. Antimicrob. Agents Chemother. (1981) [Pubmed]
  2. Comparison of fortimicins with other aminoglycosides and effects on bacterial ribosome and protein synthesis. Moreau, N., Jaxel, C., Le Goffic, F. Antimicrob. Agents Chemother. (1984) [Pubmed]
  3. Comparative antimicrobial activity of O-demethylfortimicin A, a derivative of fortimicin A. Girolami, R.L., Stamm, J.M. Antimicrob. Agents Chemother. (1980) [Pubmed]
  4. Antibacterial activity of fortimicin A compared with those of five other aminoglycosides, and factors affecting susceptibility tests. Thornsberry, C., Barry, A.L., Jones, R.N., Baker, C.N., Badal, R.E., Packer, R.R. Antimicrob. Agents Chemother. (1981) [Pubmed]
  5. A novel, highly efficient gene-cloning system in Micromonospora applied to the genetic analysis of fortimicin biosynthesis. Hasegawa, M. Gene (1992) [Pubmed]
  6. Worldwide disseminated armA aminoglycoside resistance methylase gene is borne by composite transposon Tn1548. Galimand, M., Sabtcheva, S., Courvalin, P., Lambert, T. Antimicrob. Agents Chemother. (2005) [Pubmed]
  7. Compound A49759, the 3-O-demethyl derivative of fortimicin A: in vitro comparison with six other aminoglycoside antibiotics. Jones, R.N., Thornsberry, C., Barry, A.L., Packer, R.R., Baker, C.N., Badal, R.E. Antimicrob. Agents Chemother. (1980) [Pubmed]
  8. Self cloning in Micromonospora olivasterospora of fms genes for fortimicin A (astromicin) biosynthesis. Dairi, T., Ohta, T., Hashimoto, E., Hasegawa, M. Mol. Gen. Genet. (1992) [Pubmed]
  9. Acute and subacute toxicity studies with fortimicin A sulfate (Abbott-44747), a new aminoglycoside antibiotic. Kimura, E.T., Tekeli, S., Lewkowski, J.P., Majors, K.R., Kesterson, J.W. Toxicol. Appl. Pharmacol. (1980) [Pubmed]
  10. 1-Epidactimicin, a new aminoglycoside antibiotic converted from fortimicin B by a blocked mutant of istamycin-producing Streptomyces tenjimariensis. Morioka, M., Hotta, K., Ikeda, D., Naganawa, H., Hamada, M., Okami, Y. J. Antibiot. (1989) [Pubmed]
  11. Enzymatic acetylation of fortimicin A and seldomycin factor 5 by aminoglycoside 3-acetyltransferase I: [AAC(3)-I] of E. coli KY8348. Sato, S., Iida, T., Okachi, R., Shirahata, K., Nara, T. J. Antibiot. (1977) [Pubmed]
  12. Plasmid-mediated high-level resistance to aminoglycosides in Enterobacteriaceae due to 16S rRNA methylation. Galimand, M., Courvalin, P., Lambert, T. Antimicrob. Agents Chemother. (2003) [Pubmed]
  13. Organization and nature of fortimicin A (astromicin) biosynthetic genes studied using a cosmid library of Micromonospora olivasterospora DNA. Dairi, T., Ohta, T., Hashimoto, E., Hasegawa, M. Mol. Gen. Genet. (1992) [Pubmed]
  14. 4-N-acylfortimicins B and the preparation of fortimicin A from fortimicin B. Tadanier, J., Martin, J.R., Kurath, P., Goldstein, A.W., Johnson, P. Carbohydr. Res. (1980) [Pubmed]
  15. Simultaneous analysis of the serum and urinary pharmacokinetics of fortimicin A after intravenous administration to healthy subjects. Sennello, L.T., Berman, B.I., Vance, J.F., Sonders, R.C. International journal of clinical pharmacology, therapy, and toxicology. (1982) [Pubmed]
  16. Patterns and distribution of aminoglycoside-acetylating enzymes in rapidly growing mycobacteria. Udou, T., Mizuguchi, Y., Wallace, R.J. Am. Rev. Respir. Dis. (1987) [Pubmed]
  17. Fortimicin A: collaborative in vitro susceptibility. Comparison with amikacin and gentamicin against 11,840 clinical bacterial isolates. Jones, R.N., Barry, A.L., Fuchs, P.C., Gavan, T.L., Sommers, H.M., Gerlach, E.H. Antimicrob. Agents Chemother. (1979) [Pubmed]
  18. Nephrotoxicity of dactimicin, a novel pseudo-disaccharide aminoglycoside possessing the N-formimidoyl group, compared with that of astromicin, amikacin and other aminoglycoside antibiotics in animals. Inouye, S., Niizato, T., Shomura, T., Kitasato, I. Drugs under experimental and clinical research. (1989) [Pubmed]
  19. Fortimicins A and B, new aminoglycoside antibiotics. II. Isolation, physico-chemical and chromatographic properties. Okachi, R., Takasawa, S., Sato, T., Sato, S., Yamamoto, M., Kawamoto, I., Nara, T. J. Antibiot. (1977) [Pubmed]
  20. Studies on a new aminoglycoside antibiotic, dactimicin. II. Isolation, structure and chemical degradation. Ohba, K., Tsuruoka, T., Mizutani, K., Kato, N., Omoto, S., Ezaki, N., Inouye, S., Niida, T., Watanabe, K. J. Antibiot. (1981) [Pubmed]
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