Disease relevance of minocycline

• Minocyclin was effective against all strains with the exception of E. coli 0159, 025, 0164 and 063, which were moderately susceptible [1].
• In an organ culture system using newborn mouse calvaria, the conditioned medium of H-31 cells increased the concentration of calcium in the medium, and this effect was inhibited by minocyclin, indicating that bone resorption occurred in this system [2].
• We report on a 37-yr-old woman with known antemortem ingestion of minocyclin who died suddenly from a ruptured cerebral aneurysm [3].
• The authors report a study carried out on 82 patients affected with gonococcal urethritis, in order to investigate the activity of minocyclin in the prevention of postgonococcal urethritis [4].
• Accordingly, pleurodesis with minocyclin was undertaken, which was fortunately effective for controlling the pleural effusion [5].
• Our finding that minocycline has a harmful effect on patients with ALS has implications for trials of minocycline in patients with other neurological disorders, and for how potential neuroprotective agents are screened for use in patients with ALS [6].

High impact information on minocycline

• Dapsone or minocyclin are effective treatments; both of those agents inhibit migration and/or function of neutrophils [7].
• The protection against apoptosis as conferred by minocyclin may be incomplete, with failed apoptosis and development of autoimmunity as a result [8].
• This appears to be the only case of minocyclin-associated "black thyroid" in which extensive immunohistochemical investigations have been performed [3].
• Several sclerosing agents have been reported in the literature, including doxycylin, minocyclin, tetracyclines, bleomycin, cisplatin, etoposide, fluorouracil, interferon-beta, Corynebacterium parvum, and talc which gives the best results [9].
• In this paper the authors present the first application obtained on different types of bacteria (Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, Proteus vulgaris) submitted to five antibiotics (gentamycin, minocyclin, cephalotin, spiramycin, sobramycin) [10].

Psychiatry related information on minocycline

• On the basis of these results, minocycline may prove to be a good candidate as an effective therapeutic agent for Alzheimer's disease [11].

References