Disease relevance of sulfaguanidine

• 6 out of 7 patients with severe neutropenia associated with the use of amodiaquine for malaria prophylaxis amodiaquine (400 mg weekly) plus proguanil (200 mg daily); 1 of these patients had also taken cotrimoxazole and another had taken sulphaguanidine [1].
• Erythema multiforme from sulfaguanidine [2].
• Fixed drug eruption caused by sulfaguanidine [3].
• Induction of meiotic chromosomal aberrations by sulphaguanidine [4].

High impact information on sulfaguanidine

• Cytogenetic effects of sulphadiazine and sulphaguanidine on mitotic cells of male mice [5].
• The influences of drug core (sulphanilamide, sulphaguanidine and sulphathiazole) and dissolution media (distilled water, USP HCl and phosphate buffers) on the drug release properties of the pectinate microspheres were examined [6].
• Determination of hydration kinetics of sulfaguanidine anhydrate in aqueous solution by calorimetry [7].
• Spectrofluorimetry and room temperature photochemically-induced fluorescence (RTPF) have been applied to the determination of sulphacetamide (SAC), sulphaguanidine (SG) and sulphamethazine (SMT) in milk and pharmaceutical formulations [8].
• The addition of sulphaguanidine increased phytate digestibility without changing the activities of acid and alkaline phosphatase or alkaline phytase of the intestinal mucosa [9].

Biological context of sulfaguanidine

• However, dietary sulphaguanidine enhanced phytate digestibility, suggesting that alterations in the diet which modify either the composition or metabolism of the gastrointestinal microflora may be beneficial in enhancing the in vivo hydrolysis of phytate [9].
• The pharmacokinetics of sulfaguanidine in rats was studied after its intravenous or oral administration [10].
• In 39 patients, the 'classical' pretreatment for colorectal surgery (mechanical purgation, laxatives, irrigation and sulfaguanidine administration) was supplemented with the oral administration of 750 mg metronidazole daily for 3 days [11].

Associations of sulfaguanidine with other chemical compounds

• Effects of sulfaguanidine and amino acid imbalances on the induction of niacin deficiency in mature and immature Japanese quail (Coturnix coturnix japonica) [12].
• The extent of drug-pectin interaction was highest in microspheres containing sulphanilamide, followed by sulphaguanidine and sulphathiazole, opposite to that of drug content [13].
• The enhancing effect of pyrrolidone derivatives on the percutaneous penetration of sulfaguanidine, aminopyrine and sudan III was investigated using in vitro technique and excised rat skin [14].

References