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Chemical Compound Review

AC1Q5COG     (6E,8E,11E,14E)-5-oxoicosa- 6,8,11,14...

Synonyms: AR-1G9307, AKOS015911180, FT-0642611, AC1NS43H, I14-39201, ...
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High impact information on 5-Oxo-eicosatetraenoate


Biological context of 5-Oxo-eicosatetraenoate


Anatomical context of 5-Oxo-eicosatetraenoate


Associations of 5-Oxo-eicosatetraenoate with other chemical compounds


Gene context of 5-Oxo-eicosatetraenoate


  1. International Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor. Brink, C., Dahlén, S.E., Drazen, J., Evans, J.F., Hay, D.W., Rovati, G.E., Serhan, C.N., Shimizu, T., Yokomizo, T. Pharmacol. Rev. (2004) [Pubmed]
  2. Biological inactivation of 5-oxo-6,8,11,14-eicosatetraenoic acid by human platelets. Powell, W.S., Gravel, S., Khanapure, S.P., Rokach, J. Blood (1999) [Pubmed]
  3. 5-oxo-6,8,11,14-eicosatetraenoic acid stimulates the release of the eosinophil survival factor granulocyte/macrophage colony-stimulating factor from monocytes. Stamatiou, P.B., Chan, C.C., Monneret, G., Ethier, D., Rokach, J., Powell, W.S. J. Biol. Chem. (2004) [Pubmed]
  4. Effects of 5-oxo-6,8,11,14-eicosatetraenoic acid on expression of CD11b, actin polymerization, and adherence in human neutrophils. Powell, W.S., Gravel, S., Halwani, F., Hii, C.S., Huang, Z.H., Tan, A.M., Ferrante, A. J. Immunol. (1997) [Pubmed]
  5. Eotaxin and RANTES enhance 5-oxo-6,8,11,14-eicosatetraenoic acid-induced eosinophil chemotaxis. Powell, W.S., Ahmed, S., Gravel, S., Rokach, J. J. Allergy Clin. Immunol. (2001) [Pubmed]
  6. 5-Oxo-Eicosatetraenoic Acid-Induced Chemotaxis: Identification of a Responsible Receptor hGPCR48 and Negative Regulation by G Protein G12/13. Koike, D., Obinata, H., Yamamoto, A., Takeda, S., Komori, H., Nara, F., Izumi, T., Haga, T. J. Biochem. (2006) [Pubmed]
  7. 5-Oxo-6,8,11,14-eicosatetraenoic acid is a potent stimulator of human eosinophil migration. Powell, W.S., Chung, D., Gravel, S. J. Immunol. (1995) [Pubmed]
  8. 5-Oxo-eicosatetraenoate is a broadly active, eosinophil-selective stimulus for human granulocytes. O'Flaherty, J.T., Kuroki, M., Nixon, A.B., Wijkander, J., Yee, E., Lee, S.L., Smitherman, P.K., Wykle, R.L., Daniel, L.W. J. Immunol. (1996) [Pubmed]
  9. Stimulating properties of 5-oxo-eicosanoids for human monocytes: synergism with monocyte chemotactic protein-1 and -3. Sozzani, S., Zhou, D., Locati, M., Bernasconi, S., Luini, W., Mantovani, A., O'Flaherty, J.T. J. Immunol. (1996) [Pubmed]
  10. 5-Oxo-6,8,11,14-eicosatetraenoic acid is a potent chemoattractant for human basophils. Sturm, G.J., Schuligoi, R., Sturm, E.M., Royer, J.F., Lang-Loidolt, D., Stammberger, H., Amann, R., Peskar, B.A., Heinemann, A. J. Allergy Clin. Immunol. (2005) [Pubmed]
  11. 5-Oxo-6,8,11,14-eicosatetraenoic acid induces important eosinophil transmigration through basement membrane components: comparison of normal and asthmatic eosinophils. Guilbert, M., Ferland, C., Bossé, M., Flamand, N., Lavigne, S., Laviolette, M. Am. J. Respir. Cell Mol. Biol. (1999) [Pubmed]
  12. Formation of a 5-oxo metabolite of 5,8,11,14,17-eicosapentaenoic acid and its effects on human neutrophils and eosinophils. Powell, W.S., Gravel, S., Gravelle, F. J. Lipid Res. (1995) [Pubmed]
  13. Hierarchy of eosinophil chemoattractants: role of p38 mitogen-activated protein kinase. Schratl, P., Sturm, E.M., Royer, J.F., Sturm, G.J., Lippe, I.T., Peskar, B.A., Heinemann, A. Eur. J. Immunol. (2006) [Pubmed]
  14. Stimulation of human neutrophils by 5-oxo-6,8,11,14-eicosatetraenoic acid by a mechanism independent of the leukotriene B4 receptor. Powell, W.S., Gravel, S., MacLeod, R.J., Mills, E., Hashefi, M. J. Biol. Chem. (1993) [Pubmed]
  15. Synthesis of 5-oxo-6,8,11,14-eicosatetraenoic acid and identification of novel omega-oxidized metabolites in the mouse macrophage. Hevko, J.M., Bowers, R.C., Murphy, R.C. J. Pharmacol. Exp. Ther. (2001) [Pubmed]
  16. 5-Oxo-ETE analogs and the proliferation of cancer cells. O'Flaherty, J.T., Rogers, L.C., Paumi, C.M., Hantgan, R.R., Thomas, L.R., Clay, C.E., High, K., Chen, Y.Q., Willingham, M.C., Smitherman, P.K., Kute, T.E., Rao, A., Cramer, S.D., Morrow, C.S. Biochim. Biophys. Acta (2005) [Pubmed]
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