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Chemical Compound Review

Benzo Brown MC     disodium(3Z)-3-[[4-[4-[(2E)- 2-(7-amino-1...

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Disease relevance of Benzo Brown MC

  • The C-terminal part of the protein is best conserved and most important for function; a crystal structure of this C-terminal domain of FliN from Thermotoga maritima revealed a saddle-shaped dimer formed mainly from beta strands (P. N. Brown, M. A. A. Mathews, L. A. Joss, C. P. Hill, and D. F. Blair, J. Bacteriol. 187:2890-2902, 2005) [1].
  • The permeability properties of the outer membrane of Pseudomonas aeruginosa were re-examined, since the reported conclusions are conflicting [Decad, M. G. and Nikaido, H. (1976) J. Bacteriol. 128, 325-336; Caulcott, C. A., Brown, M. R. W. and Gonda, I. (1984) FEMS Microbiol. Lett. 21, 119-123] [2].

High impact information on Benzo Brown MC

  • [van Driel, I. R., Goldstein, J. L., Sudhof, T. C. & Brown, M. S. (1987) J. Biol. Chem. 262, 17443-17449] showed that if the first repeat of the ligand-binding domain (encoded by exon 2) is deleted, the receptor fails to bind an anti-LDL receptor monoclonal antibody (IgG-C7) but continues to bind LDL with high affinity [3].
  • We had previously shown that DNA rearrangement events occurred in the promoter region, specifically at inactivation of this ES (K. M. Gottesdiener, H.-M. Chung, S. L. Brown, M. G.-S. Lee, and L. H. T. Van der Ploeg, Mol. Cell. Biol. 11:2467-2477, 1991) [4].
  • We also isolated a murine cDNA encoding a hepatic type enzyme, designated AceCS1, identical to one reported recently (Luong, A., Hannah, V. C., Brown, M. S., and Goldstein, J. L. (2000) J. Biol. Chem. 275, 26458-26466) [5].
  • In an accompanying paper (Cheng, D., Espenshade, P. J., Slaughter, C. A., Jaen, J. C., Brown, M. S., and Goldstein, J. L. (1999), J. Biol. Chem., 274, 22805-22812), we develop an in vitro assay to characterize the activity of purified recombinant S1P [6].
  • The properties of the hepatocyte monocarboxylate transporter are consistent with the presence of a distinct isoform of MCT in liver cells as suggested by the cloning and sequencing of MCT2 from hamster liver (Garcia, C. K., Brown, M. S., Pathak, R. K., and Goldstein, J. L. (1995) J. Biol. Chem. 270, 1843-1849) [7].

Biological context of Benzo Brown MC

  • Structural modeling studies indicate that the E2 domain, which is proposed to bind the C protein (E2 398T, 399P, and 400Y), is located at a sufficient distance from the membrane to occupy the C protein binding cleft (S. Lee, K. E. Owen, H. K. Choi, H. Lee, G. Lu, G. Wengler, D. T. Brown, M. G. Rossmann, and R. J. Kuhn, Structure 4:531-541, 1996) [8].
  • When ts61S HA is synthesized and maintained at the nonpermissive temperature (39.5 degrees), the HA is defective in transport in the exocytic pathway and is retained in the endoplasmic reticulum (S. Nakajima, D. J. Brown, M., Ueda, K., Nakajima, A. Suguira, A. K. Pattnaik, and D. P. Nayak, 1986, Virology 154, 279-285) [9].
  • This antiserum recognizes neural cell adhesion molecule in the basal lamina and extracellular matrix of denervated mouse muscles (1988, Booth C. M. and Brown M. C., Neuroscience 27, 699-709) [10].
  • [(3)H]luteolin covalently labels two forms (11kDa and 35kDa proteins) of type II binding sites in rat uterine nuclear extracts [K. Shoulars, T. Brown, M. Alejandro, J. Crowley, B. Markaverich, Identification of rat uterine nuclear type II [(3)H]estradiol binding sites as histone H4, Biochem. Biophys. Res. Commun. 296 (2002) 1083-1090] [11].
  • Television commercials, billboards, and public health lectures can be advantageous in a campaign to educate about stroke and the need to seek help immediately when experiencing symptoms, to halt the ischemic damage Brown M [12].

Anatomical context of Benzo Brown MC

  • Minimal transformants of rat F111 fibroblasts were established after infection with the large T antigen (large T)-encoding retroviral expression vector pZIPTEX (M. Brown, M. McCormack, K. Zinn, M. Farrell, I. Bikel, and D. Livingston, J. Virol. 60:290-293, 1986) [13].

Gene context of Benzo Brown MC

  • This molecule regulates ligand binding of alpha 2MR/LRP (Herz, J., Goldstein, J. L., Strickland, D. K., Ho, Y. K., and Brown, M. S. (1991) J. Biol. Chem. 266, 21232-21238) [14].
  • Using surface plasmon resonance technology, which avoids several pitfalls of conventional binding assays, we recently reported that rat CD2 binds rat CD48 with a very low affinity (Kd 60-90 microM) and dissociates rapidly (koff > or = 6 s-1) [van der Merwe, P. A., Brown, M. H., Davis, S. J., & Barclay, A. N. (1993) EMBO J. 12, 4945-4954] [15].
  • This adsorbent was employed for the removal of azo dye such as Direct Dark Brown M and Acid Mordant Brown RH [16].


  1. Organization of FliN subunits in the flagellar motor of Escherichia coli. Paul, K., Blair, D.F. J. Bacteriol. (2006) [Pubmed]
  2. A small diffusion pore in the outer membrane of Pseudomonas aeruginosa. Yoneyama, H., Nakae, T. Eur. J. Biochem. (1986) [Pubmed]
  3. Deletion in the first cysteine-rich repeat of low density lipoprotein receptor impairs its transport but not lipoprotein binding in fibroblasts from a subject with familial hypercholesterolemia. Leitersdorf, E., Hobbs, H.H., Fourie, A.M., Jacobs, M., van der Westhuyzen, D.R., Coetzee, G.A. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  4. A proposed mechanism for promoter-associated DNA rearrangement events at a variant surface glycoprotein gene expression site. Gottesdiener, K.M., Goriparthi, L., Masucci, J.P., Van der Ploeg, L.H. Mol. Cell. Biol. (1992) [Pubmed]
  5. Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate. Fujino, T., Kondo, J., Ishikawa, M., Morikawa, K., Yamamoto, T.T. J. Biol. Chem. (2001) [Pubmed]
  6. Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins. Espenshade, P.J., Cheng, D., Goldstein, J.L., Brown, M.S. J. Biol. Chem. (1999) [Pubmed]
  7. The kinetics, substrate, and inhibitor specificity of the monocarboxylate (lactate) transporter of rat liver cells determined using the fluorescent intracellular pH indicator, 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein. Jackson, V.N., Halestrap, A.P. J. Biol. Chem. (1996) [Pubmed]
  8. A single deletion in the membrane-proximal region of the Sindbis virus glycoprotein E2 endodomain blocks virus assembly. Hernandez, R., Lee, H., Nelson, C., Brown, D.T. J. Virol. (2000) [Pubmed]
  9. Influenza virus ts61S hemagglutinin is significantly defective in polypeptide folding and intracellular transport at the permissive temperature. Simpson, D.A., Lamb, R.A. Virology (1991) [Pubmed]
  10. An antibody to neural cell adhesion molecule impairs motor nerve terminal sprouting in a mouse muscle locally paralysed with botulinum toxin. Booth, C.M., Kemplay, S.K., Brown, M.C. Neuroscience (1990) [Pubmed]
  11. Nuclear type II [3H]estradiol binding sites: a histone H3-H4 complex. Shoulars, K., Rodrigues, M.A., Crowley, J.R., Turk, J., Thompson, T., Markaverich, B.M. J. Steroid Biochem. Mol. Biol. (2005) [Pubmed]
  12. Pharmacological treatment of acute ischemic stroke. Murphy, J. Critical care nursing quarterly. (2003) [Pubmed]
  13. Analysis of simian virus 40 small t antigen-induced progression of rat F111 cells minimally transformed by large T antigen. Zerrahn, J., Deppert, W. J. Virol. (1993) [Pubmed]
  14. A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Multiple regulatory sites for 39-kDa receptor-associated protein. Williams, S.E., Ashcom, J.D., Argraves, W.S., Strickland, D.K. J. Biol. Chem. (1992) [Pubmed]
  15. Human cell-adhesion molecule CD2 binds CD58 (LFA-3) with a very low affinity and an extremely fast dissociation rate but does not bind CD48 or CD59. van der Merwe, P.A., Barclay, A.N., Mason, D.W., Davies, E.A., Morgan, B.P., Tone, M., Krishnam, A.K., Ianelli, C., Davis, S.J. Biochemistry (1994) [Pubmed]
  16. Dye removal from wastewater using the adsorbent developed from sewage sludge. Chen, C.Y., Wang, P., Zhuang, Y.Y. Journal of environmental sciences (China). (2005) [Pubmed]
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