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Chemical Compound Review

AC1NUZBN     4-[(2E)-2-(2-hydroxy-4-oxo-1- cyclohexa-2,5...

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Disease relevance of Gold Yellow

  • We have continued the preclinical evaluation of the efficacy and safety of the hexadentate phenolic aminocarboxylate iron chelator N, N'-bis(2-hydroxybenzyl) ethylenediamine-N, N'-diacetic acid monosodium salt (NaHBED) for the treatment of both chronic transfusional iron overload and acute iron poisoning [1].
  • Risedronate monosodium [1-hydroxy-2-(3-pyridinyl)ethylidene bisphosphonic acid monosodium salt] is a pyridinyl bisphosphonate drug under development as a treatment for Paget's disease of bone and other metabolic bone disorders [2].
  • We examined the therapeutic effects of the inflammatory cell infiltration inhibitor IS-741 (N-(2-((ethylsulfonyl)amino)-5-(trifluoromethyl)-3-pyridinyl)-cyclohexanecarboxamide monosodium salt monohydrate) on a rat colitis model [3].
  • A rapid, sensitive and specific high-performance liquid chromatographic (HPLC) assay is reported for the determination of 4-amino-1-hydroxybutane-1, 1-diphosphonic acid (AHBuDP) monosodium salt trihydrate, a new inhibitor of bone resorption [4].

High impact information on Gold Yellow

  • Cell viability was assessed by 2-(2-methoxy-4-nitrophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium monosodium salt assay, while apoptosis was determined by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling stain [5].
  • METHODS: A cell counter was used to determine the number of viable cells, followed by application of the tetrazolium compound WST-8 [2-(2-methoxy-4-nitrophenyl)-3-(4 nitrophenyl))-5-(2,4-disulfophenyl)-2H-tetrazolium, monosodium salt, colorimetric method to evaluate cell viability in this cytotoxicity assay [6].
  • 4-[[(4-Chlorophenyl)(5-fluoro-2-hydroxyphenyl)methylene]amino]butanoic acid monosodium salt (4) and 4-[[(4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methylene]amino]butanamide (5) blocked bicuculline-induced lethality and convulsions and displaced [3H]gammaAbu from its membrane binding sites [7].
  • The amount of biologically active guinea pig IFN was quantified by estimating viable cell numbers colorimetrically by means of a tetrazolium compound, 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium monosodium salt (WST-1) and 1-methoxy-5-methylphenazinium methylsulfate (PMS) [8].
  • A new liquid chromatographic ligand exchange CSP has been prepared by covalently bonding (S)-N,N-carboxymethyl undecyl leucinol monosodium salt onto silica gel and employed in resolving various alpha-amino acids [9].

Biological context of Gold Yellow


Anatomical context of Gold Yellow


Associations of Gold Yellow with other chemical compounds


Gene context of Gold Yellow

  • After a 12-h fast, six healthy volunteers were given [99mTc]iminodiacetic acid monosodium salt (IDA) intravenously (5 mCi) [20].
  • 7-Nitro indazole monosodium salt (7-NINA), a specific inhibitor of nNOS, had no significant effect on the resting tone, whereas the general NOS blocker N(G)-nitro-L-arginine (L-NA) induced strong contraction [21].

Analytical, diagnostic and therapeutic context of Gold Yellow


  1. HBED ligand: preclinical studies of a potential alternative to deferoxamine for treatment of chronic iron overload and acute iron poisoning. Bergeron, R.J., Wiegand, J., Brittenham, G.M. Blood (2002) [Pubmed]
  2. Paget's disease of bone: reduction of disease activity with oral risedronate. Hosking, D.J., Eusebio, R.A., Chines, A.A. Bone (1998) [Pubmed]
  3. Efficacy of the inflammatory cell infiltration inhibitor IS-741 on colitis induced by dextran sulfate sodium in the rat. Yotsuya, S., Shikama, H., Imamura, M. Jpn. J. Pharmacol. (2001) [Pubmed]
  4. The determination of 4-amino-1-hydroxybutane-1,1-diphosphonic acid monosodium salt trihydrate in pharmaceutical dosage forms by high-performance liquid chromatography. De Marco, J.D., Biffar, S.E., Reed, D.G., Brooks, M.A. Journal of pharmaceutical and biomedical analysis. (1989) [Pubmed]
  5. Involvement of de novo ceramide synthesis in radiocontrast-induced renal tubular cell injury. Itoh, Y., Yano, T., Sendo, T., Sueyasu, M., Hirano, K., Kanaide, H., Oishi, R. Kidney Int. (2006) [Pubmed]
  6. Antitumoral action of the neurokinin-1-receptor antagonist L-733,060 and mitogenic action of substance P on human retinoblastoma cell lines. Muñoz, M., Rosso, M., Pérez, A., Coveñas, R., Rosso, R., Zamarriego, C., Soult, J.A., Montero, I. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  7. New anticonvulsants: Schiff bases of gamma-aminobutyric acid and gamma-aminobutyramide. Kaplan, J.P., Raizon, B.M., Desarmenien, M., Feltz, P., Headley, P.M., Worms, P., Lloyd, K.G., Bartholini, G. J. Med. Chem. (1980) [Pubmed]
  8. A new assay system for guinea pig interferon biological activity. Yamamoto, T., Jeevan, A., Ohishi, K., Nojima, Y., Umemori, K., Yamamoto, S., McMurray, D.N. J. Interferon Cytokine Res. (2002) [Pubmed]
  9. Preparation and application of a new ligand exchange chiral stationary phase for the liquid chromatographic resolution of alpha-amino acid enantiomers. Hyun, M.H., Han, S.C., Lee, C.W., Lee, Y.K. Journal of chromatography. A. (2002) [Pubmed]
  10. A celecoxib derivative potently inhibits proliferation of colon adenocarcinoma cells by induction of apoptosis. Kusunoki, N., Ito, T., Sakurai, N., Handa, H., Kawai, S. Anticancer Res. (2006) [Pubmed]
  11. Cisplatin inhibits the expression of X-linked inhibitor of apoptosis protein in human LNCaP cells. Nomura, T., Mimata, H., Yamasaki, M., Nomura, Y. Urol. Oncol. (2004) [Pubmed]
  12. Lymphocyte proliferation response during Eimeria tenella infection assessed by a new, reliable, nonradioactive colorimetric assay. Miyamoto, T., Min, W., Lillehoj, H.S. Avian Dis. (2002) [Pubmed]
  13. Experimental determination of human erythrocyte membrane permeability coefficients for a series of amides. Gordiyenko, O.I., Gordiyenko, Y.E., Linnik, T.P., Gordiyenko, E.O. Cryo letters. (2005) [Pubmed]
  14. The X-linked inhibitor of apoptosis protein inhibits taxol-induced apoptosis in LNCaP cells. Nomura, T., Mimata, H., Takeuchi, Y., Yamamoto, H., Miyamoto, E., Nomura, Y. Urol. Res. (2003) [Pubmed]
  15. A novel celecoxib derivative potently induces apoptosis of human synovial fibroblasts. Kusunoki, N., Ito, T., Sakurai, N., Suguro, T., Handa, H., Kawai, S. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  16. In vitro photodecomposition of uric acid in presence of riboflavin II. Newburger, J., Combs, A.B., Hsu, T.F. Journal of pharmaceutical sciences. (1977) [Pubmed]
  17. Midkine protects hepatocellular carcinoma cells against TRAIL-mediated apoptosis through down-regulation of caspase-3 activity. Ohuchida, T., Okamoto, K., Akahane, K., Higure, A., Todoroki, H., Abe, Y., Kikuchi, M., Ikematsu, S., Muramatsu, T., Itoh, H. Cancer (2004) [Pubmed]
  18. Evaluation of the effects of risedronate on hepatic microsomal drug metabolizing enzyme activities following administration to rats for 14 days: lack of an induction response. Smith, B.J., Hu, J.K., Schwecke, W.P. Drug and chemical toxicology. (1998) [Pubmed]
  19. Effect of chemical protectors on the response of the intestine to roentgen or fission neutron irradiation. Sigdestad, C.P., Connor, A.M., Scott, R.M. Acta radiologica: therapy, physics, biology. (1976) [Pubmed]
  20. Effect of cholecystokinin-A receptor blockade on postprandial insulinaemia and gastric emptying in humans. Hidalgo, L., Clavé, P., Estorch, M., Rodríguez-Espinosa, J., Rovati, L., Greeley, G.H., Capellà, G., Lluís, F. Neurogastroenterol. Motil. (2002) [Pubmed]
  21. Role of nitric oxide and thromboxane in the maintenance of cerebrovascular tone. Benyó, Z., Görlach, C., Wahl, M. Kidney Int. Suppl. (1998) [Pubmed]
  22. Practical synthesis of the new carbapenem antibiotic ertapenem sodium. Williams, J.M., Brands, K.M., Skerlj, R.T., Jobson, R.B., Marchesini, G., Conrad, K.M., Pipik, B., Savary, K.A., Tsay, F.R., Houghton, P.G., Sidler, D.R., Dolling, U.H., DiMichele, L.M., Novak, T.J. J. Org. Chem. (2005) [Pubmed]
  23. Effects of RSR13 and oxygen on the cytotoxicity of cisplatin and carboplatin to EMT6 mouse mammary tumor cells in vitro and in vivo. Donnelly, E.T., Kelley, M., Rockwell, S. Cancer Chemother. Pharmacol. (2004) [Pubmed]
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