Disease relevance of Arsenal

• Hepatitis C: the 'silent stalker' [1].
• Neurodegenerative disease. Guam's deadly stalker: on the loose worldwide [2]?
• Infectious disease. Siberia's deadly stalker emerges from the shadows [3].

Psychiatry related information on Arsenal

• A female stalker typically seeks to attain a close intimacy with her victim, who usually is someone previously known and frequently is a person cast in the professional role of helper [4].
• A case of de Clérambault syndrome in a male stalker with paranoid schizophrenia [5].
• This article outlines a structured approach to assessment and management involving domains based on the relationship between stalker and victim, the type of motivation driving the stalking, the stalker's risk profile, the victim's risk profile, and finally, the legal and mental health context [6].
• Variables compared included age, sex, marital status, level of education, substance abuse, Axis I diagnosis, military history, organicity, and whether the victim was a casual associate or had a previous attachment to the stalker [7].

High impact information on Arsenal

• Before crosses, the location of Stalker on chromosomes is fairly stable in a particular strain but thereafter numerous changes in Stalker distribution take place [8].
• The number of Stalker copies per genome and chromosomal localization vary among D. melanogaster strains [8].
• The mutation in the yellow locus has been cloned and found to depend on insertion into the coding region of the gene of a novel mobile genetic element designated as Stalker [8].
• The sequencing of Stalker termini reveals 405 bp direct repeats (LTRs) and a target 3 bp duplication, as well as some other sequences typical of retrovirus-like retrotransposons [8].
• The e(y)1(ul) mutation, induced by the insertion of Stalker into the coding region, leads to the replacement of 25 carboxy-terminal amino acids by 17 amino acids encoded by the Stalker sequences and to a decrease of the e(y)1 transcription level [9].

Biological context of Arsenal

• The nucleotide sequence of a portion of this functional beta origin was determined in an earlier study (Stalker, D., Kolter, R., and Helinski, D. (1982) J. Mol. Biol. 161, 33-43) [10].
• These results support the theory of Stalker (1956) that parthenogenesis is favored in environments in which sexual reproduction is difficult or impossible [11].
• The repeats are located mainly in the Y chromosome and in the heterochromatin of the right arm of chromosome 2 (2Rh), where they are colocalized with the Stalker retrotransposon [12].
• AS-specific DNA methylation is found in patients carrying 3-4 Mb deletions ( approximately 70%), paternal uniparental disomy (3-5%) or imprinting center mutations (2-9%), while normal methylation pattern with biparental inheritance characterizes the remaining approximately 20-25% AS patients (Stalker et al.,1998; Tsai et al.,1998) [13].

Gene context of Arsenal

• The transposons causing the mutations are: P element (5 alleles), gypsy (3 alleles), 17.6, HMS Beagle, springer, Delta 88, prygun, Stalker, and a new mobile element which was named roamer (2 alleles) [14].
• A novel simple satellite DNA is colocalized with the Stalker retrotransposon in Drosophila melanogaster heterochromatin [12].

Analytical, diagnostic and therapeutic context of Arsenal

• Two corresponded to true fixations of a roo and a Stalker element, and the others were artefacts of the in situ hybridization technique caused by the presence of genomic DNA flanking the transposable elements (TEs) in the probes [15].

References