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Chemical Compound Review

Amaranthin     (2S)-5-[(2S,3R,4S,5S,6R)-3- [(2R,3R,4S,5S...

Synonyms: AC1O3DE0, C08537, 15167-84-7
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Disease relevance of Amaranthin

 

High impact information on Amaranthin

  • A native Mr = 54,000 was determined by gel filtration suggesting that amaranthin exists as a homodimer [4].
  • Amaranthin formed a precipitate with asialo-bovine submaxillary mucin, asialo-ovine submaxillary, porcine submaxillary mucin, asialo-fetuin and asialoglycophorin [4].
  • NeuAc alpha 2,3Gal beta 1,3GalNAc alpha-O-(CH2)8CO2CH3 was as potent an inhibitor as Gal beta 1,3GalNAc alpha-O-(CH2)8CO2-CH3, and amaranthin was precipitated by NeuAc alpha 2,3Gal beta 1,3GalNAc alpha-O-BSA (where BSA is bovine serum albumin), indicating that the amaranthin-combining site tolerates substitutions at the C'-3 hydroxyl group [4].
  • One band at approximately 200 kDa, and a smear at approximately 100 kDa, were reactive only with Amaranthin [5].
  • In the present study we have analyzed by light and electron microscopy the distribution and subcellular localization of Amaranthin binding sites in normal, dysplastic and neoplastic colonic epithelium [1].
 

Biological context of Amaranthin

 

Anatomical context of Amaranthin

 

Associations of Amaranthin with other chemical compounds

  • Eu(3+) can directly enter or be carried by the artificial ion carrier A23187 into plant cells through the calcium ion (Ca(2+)) channel and then partially resume the synthesis of amaranthin in the Amaranthus caudatus growing in the dark [8].
  • METHODS: Binding of amaranthin in segments of proximal and distal colon was studied in starved, refed, and control Wistar rats and was compared to tritiated thymidine labeling and proliferating cell nuclear-antigen expression [9].
 

Gene context of Amaranthin

  • The lectin amaranthin, purified from the seeds of Amaranthus caudatus, has been shown to react specifically with the Gal beta 1,3GalNAc-alpha and the NeuAc alpha 2,3Gal beta 1,3GalNAc-alpha sequence which represent the T antigen and the cryptic T antigen, respectively [6].
 

Analytical, diagnostic and therapeutic context of Amaranthin

References

  1. Studies on the Thomsen-Friedenreich antigen in human colon with the lectin Amaranthin. Normal and neoplastic epithelium express only cryptic T antigen. Sata, T., Roth, J., Zuber, C., Stamm, B., Rinderle, S.J., Goldstein, I.J., Heitz, P.U. Lab. Invest. (1992) [Pubmed]
  2. Differentiation-related expression of the Thomsen-Friedenreich glycotope in developing human lung and in lung carcinoma: lack of association with malignancy. Toma, V., Sata, T., Vogt, P., Komminoth, P., Heitz, P.U., Roth, J. Cancer (1999) [Pubmed]
  3. A ribosome-inactivating protein from Amaranthus viridis. Kwon, S.Y., An, C.S., Liu, J.R., Paek, K.H. Biosci. Biotechnol. Biochem. (1997) [Pubmed]
  4. Isolation and characterization of amaranthin, a lectin present in the seeds of Amaranthus caudatus, that recognizes the T- (or cryptic T)-antigen. Rinderle, S.J., Goldstein, I.J., Matta, K.L., Ratcliffe, R.M. J. Biol. Chem. (1989) [Pubmed]
  5. Specialized expression of simple O-glycans along the rat kidney nephron. Toma, V., Zuber, C., Sata, T., Roth, J. Glycobiology (1999) [Pubmed]
  6. Expression patterns of the T antigen and the cryptic T antigen in rat fetuses: detection with the lectin amaranthin. Sata, T., Zuber, C., Rinderle, S.J., Goldstein, I.J., Roth, J. J. Histochem. Cytochem. (1990) [Pubmed]
  7. Binding of amaranthin in photoreceptors of monkey retina. Uehara, F., Ohba, N., Sameshima, M., Unoki, K., Okubo, A., Yanagita, T., Sugata, M., Iwakiri, N., Nakagawa, S. Jpn. J. Ophthalmol. (1994) [Pubmed]
  8. Research of the entry of rare earth elements Eu3+ and La3+ into plant cell. Gao, Y., Zeng, F., Yi, A., Ping, S., Jing, L. Biological trace element research. (2003) [Pubmed]
  9. Amaranthin lectin binding in the rat colon: response to dietary manipulation. Atillasoy, E.O., Kapetanakis, A., Itzkowitz, S.H., Holt, P.R. Mt. Sinai J. Med. (1998) [Pubmed]
  10. Thomsen-Friedenreich glycotope is expressed in developing and normal kidney but not in renal neoplasms. Toma, V., Zuber, C., Sata, T., Komminoth, P., Hailemariam, S., Eble, J.N., Heitz, P.U., Roth, J. Hum. Pathol. (2000) [Pubmed]
 
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