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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Systhane     2-(4-chlorophenyl)-2-(1,2,4- triazol-1...

Synonyms: Rally, MYCLOBUTANIL, Nu-Flow M, Nova W, Synthane 12E, ...
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Disease relevance of Systhane


High impact information on Systhane


Chemical compound and disease context of Systhane


Biological context of Systhane


Associations of Systhane with other chemical compounds


Gene context of Systhane

  • Many of these CYP, XME and transporter genes are regulated by xeno-sensing nuclear receptors, and hierarchical clustering of CAR/PXR-regulated genes demonstrated the similarities of toxicogenomic responses in liver between all four triazoles and in testis between myclobutanil and triadimefon [5].

Analytical, diagnostic and therapeutic context of Systhane


  1. Toxicity profiles in rats treated with tumorigenic and nontumorigenic triazole conazole fungicides: propiconazole, triadimefon, and myclobutanil. Wolf, D.C., Allen, J.W., George, M.H., Hester, S.D., Sun, G., Moore, T., Thai, S.F., Delker, D., Winkfield, E., Leavitt, S., Nelson, G., Roop, B.C., Jones, C., Thibodeaux, J., Nesnow, S. Toxicologic pathology (2006) [Pubmed]
  2. Transcriptional Profiles in Liver from Rats Treated with Tumorigenic and Non-tumorigenic Triazole Conazole Fungicides: Propiconazole, Triadimefon, and Myclobutanil. Hester, S.D., Wolf, D.C., Nesnow, S., Thai, S.F. Toxicologic pathology (2006) [Pubmed]
  3. Transcriptional profiles in liver from mice treated with hepatotumorigenic and nonhepatotumorigenic triazole conazole fungicides: propiconazole, triadimefon, and myclobutanil. Ward, W.O., Delker, D.A., Hester, S.D., Thai, S.F., Wolf, D.C., Allen, J.W., Nesnow, S. Toxicologic pathology (2006) [Pubmed]
  4. Disruption of testosterone homeostasis as a mode of action for the reproductive toxicity of triazole fungicides in the male rat. Goetz, A.K., Ren, H., Schmid, J.E., Blystone, C.R., Thillainadarajah, I., Best, D.S., Nichols, H.P., Strader, L.F., Wolf, D.C., Narotsky, M.G., Rockett, J.C., Dix, D.J. Toxicol. Sci. (2007) [Pubmed]
  5. Gene expression profiling in liver and testis of rats to characterize the toxicity of triazole fungicides. Tully, D.B., Bao, W., Goetz, A.K., Blystone, C.R., Ren, H., Schmid, J.E., Strader, L.F., Wood, C.R., Best, D.S., Narotsky, M.G., Wolf, D.C., Rockett, J.C., Dix, D.J. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  6. Toxicity profiles in mice treated with hepatotumorigenic and non-hepatotumorigenic triazole conazole fungicides: propiconazole, triadimefon, and myclobutanil. Allen, J.W., Wolf, D.C., George, M.H., Hester, S.D., Sun, G., Thai, S.F., Delker, D.A., Moore, T., Jones, C., Nelson, G., Roop, B.C., Leavitt, S., Winkfield, E., Ward, W.O., Nesnow, S. Toxicologic pathology (2006) [Pubmed]
  7. Bioavailability of butachlor and myclobutanil residues in soil to earthworms. Yu, Y.L., Wu, X.M., Li, S.N., Fang, H., Tan, Y.J., Yu, J.Q. Chemosphere (2005) [Pubmed]
  8. Bioaccumulation and biotransformation of chiral triazole fungicides in rainbow trout (Oncorhynchus mykiss). Konwick, B.J., Garrison, A.W., Avants, J.K., Fisk, A.T. Aquat. Toxicol. (2006) [Pubmed]
  9. Solid-phase microextraction and gas chromatography-mass spectrometry for the rapid screening of triazole residues in wine and strawberries. Zambonin, C.G., Cilenti, A., Palmisano, F. Journal of chromatography. A. (2002) [Pubmed]
  10. An exploration of the relationship between adsorption and bioavailability of pesticides in soil to earthworm. Yu, Y.L., Wu, X.M., Li, S.N., Fang, H., Zhan, H.Y., Yu, J.Q. Environ. Pollut. (2006) [Pubmed]
  11. Toxicity of pesticides to predatory mites and insects in apple-tree site under field conditions. Raudonis, L., Surviliene, E., Valiuskaite, A. Environ. Toxicol. (2004) [Pubmed]
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