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Disease relevance of Mites

  • Cross-reactivity between the house dust mite Dermatophagoides pteronyssinus and the mange mites Psoroptes cuniculi and P. ovis. I. Demonstration of antibodies to the house dust mite allergen Dpt 12 in sera from P. cuniculi-infested rabbits [1].
  • CONCLUSIONS: Children with AR and concomitant atopic dermatitis show a preferential sensitization to the Dermatophagoides mites [2].
  • A polymerase chain reaction-based strategy has been developed that enables genotyping individual scabies mites [3].
  • In an open study, 21 patients suffering from chronic non-seasonal rhinitis and allergic to house mites (HDM) have been treated for 1 year with either a new extract (Pharmalagen; n = 10) or an allergoid, pyridine denatured, extract (Alavac; n = 11), both precipitated with AlOH3 (depot) [4].
  • A statistically significant increase in mites was found in all subgroups of rosacea, being most marked in those with steroid-induced rosacea [5].

Psychiatry related information on Mites


High impact information on Mites

  • Similar patterns were not found for the combination of allergy to dust mites or cat dander and high levels of the allergen [7].
  • These mites are able to paralyse insects 150,000 times their size and their venom is effective in a broad range of insect species [8].
  • Whereas the rice ubiquitin2 (rubq2) promoter in rice (Oryza sativa) line IR24 contains two nested MITEs (Kiddo and MDM1), that in line T309 has lost Kiddo, providing an opportunity to understand the role of MITEs in promoter function [9].
  • When methylation of the MITEs was blocked by 5-azacytidine treatment, a threefold increase in the endogenous rubq2 transcript level was detected in IR24 compared with that in T309 [9].
  • These results suggest that SCCA2 acts as a cross-class serpin targeting an extrinsic cysteine proteinase derived from house dust mites and that it may have a protective role against biological reactions caused by mites [10].

Chemical compound and disease context of Mites


Biological context of Mites

  • Individual mites were genotyped at hypervariable microsatellite loci by a fluorescence-based polymerase chain reaction [16].
  • After a period of acclimation to the animal care facilities, the rabbits were ranked on the visual appearance of any ear lesion and the number of mites on glycerin-dipped ear swabs [17].
  • For malathion, the mean LD50 for mites from three caged layer flocks was 119.35 ppm while concentrations as high as 500 ppm gave only low mortalities (20% or less) of mites from the other flocks and LD50 values could not be calculated [18].
  • DNA sequence data were used to examine phylogenetic relationships between six species of economically important Tetranychidae mites: Eotetranychus carpini (Oudemans), E. pruni (Reck), Tetranychus pacificus McGregor, T. mcdanieli McGregor, T. turkestani Ugarov & Nikolski and T. urticae Koch [19].
  • However, the herbicide preparation had acute toxic effects on enchytraeids [no-observed-effect level (NOEL) 1.0 g a.i. /m2] and both gamasid mites (NOEL 2.4 and 5.0 g a.i./m2) [20].

Anatomical context of Mites

  • RESULTS: LFA-1 staining on epithelial cells was demonstrated in 12/13 patients allergic to mites and not in normal controls or in patients allergic to pollen tested out of the pollen season [21].
  • The effect of KB-2413 on IgE-mediated histamine and LTC4 release from leukocytes obtained from asthmatic patients who were sensitive to mites, and from human lung tissues passively sensitized with IgE myeloma serum was studied [22].
  • To obtain a deeper knowledge of this phenomenon, we studied the mites' impact on the vitellogenin titer, the total protein stores in the hemolymph, the hemocyte characteristics, and the ecdysteroid titer of adult honey bees [23].

Associations of Mites with chemical compounds

  • BACKGROUND: Dust mites are important inducers of allergic disease [24].
  • A double-blind, placebo controlled trial of solidified benzyl benzoate applied in dwellings of asthmatic patients sensitive to mites: clinical efficacy and effect on mite allergens [25].
  • Skin prick tests to work-related allergens (laboratory animal, flour, and latex) and common allergens (mites, molds, pets, and pollen) were administered at baseline and at up to 3 subsequent annual visits [26].
  • BACKGROUND: Dust mites have been shown to contain a serine protease distinct from the previously reported trypsin and chymotrypsin [27].
  • METHODS: We took monthly measurements from July to December of the amount of mites in the mattresses of asthmatic children and correlated them with symptom score, pulmonary function, and airway hyperreactivity to methacholine [28].

Gene context of Mites

  • PAX 1 contains animal danders and feathers, PAX 2 mites and insects, and PAX 3 pollens and molds [29].
  • Mites and mite products induced cells in the HSEs to secrete IL-1 alpha and IL-1 beta within 16 hr [30].
  • Of mites and zen: expression studies in a chelicerate arthropod confirm zen is a divergent Hox gene [31].
  • Using a PCR assay with a Wolbachia-specific primer pair (ftsZ), and by standard crosses, we were able to show that 71 per cent of the mites had lost the Wolbachia infection after rearing the infected population at 32+/-0.5 degrees C for four generations [32].
  • The cuticular layer of the mites located within the pilosebaceous unit was selectively immunoreactive for IgD (delta chain), alpha-1-antitrypsin and alpha-1-antichymotrypsin [33].

Analytical, diagnostic and therapeutic context of Mites


  1. Cross-reactivity between the house dust mite Dermatophagoides pteronyssinus and the mange mites Psoroptes cuniculi and P. ovis. I. Demonstration of antibodies to the house dust mite allergen Dpt 12 in sera from P. cuniculi-infested rabbits. Stewart, G.A., Fisher, W.F. J. Allergy Clin. Immunol. (1986) [Pubmed]
  2. Sensitization to dust mites in children with allergic rhinitis in Singapore: does it matter if you scratch while you sneeze? Kidon, M.I., Chiang, W.C., Liew, W.K., Lim, S.H., See, Y., Goh, A., Tan, J.P., Chay, O.M., Balakrishnan, A. Clin. Exp. Allergy (2005) [Pubmed]
  3. PCR-based assay to survey for knockdown resistance to pyrethroid acaricides in human scabies mites (Sarcoptes scabiei var hominis). Pasay, C., Walton, S., Fischer, K., Holt, D., McCarthy, J. Am. J. Trop. Med. Hyg. (2006) [Pubmed]
  4. Effects of one-year hyposensitization in allergic rhinitis. Comparison of two house dust mite extracts. Pécoud, A., Nicod, L., Badan, M., Agrell, B., Dreborg, S., Kolly, M. Allergy (1990) [Pubmed]
  5. The Demodex mite population in rosacea. Bonnar, E., Eustace, P., Powell, F.C. J. Am. Acad. Dermatol. (1993) [Pubmed]
  6. Acaricidal activity of butylidenephthalide identified in Cnidium officinale rhizome against dermatophagoides farinae and dermatophagoides pteronyssinus (Acari: Pyroglyphidae). Kwon, J.H., Ahn, Y.J. J. Agric. Food Chem. (2002) [Pubmed]
  7. The role of cockroach allergy and exposure to cockroach allergen in causing morbidity among inner-city children with asthma. Rosenstreich, D.L., Eggleston, P., Kattan, M., Baker, D., Slavin, R.G., Gergen, P., Mitchell, H., McNiff-Mortimer, K., Lynn, H., Ownby, D., Malveaux, F. N. Engl. J. Med. (1997) [Pubmed]
  8. Insect paralysis by baculovirus-mediated expression of a mite neurotoxin gene. Tomalski, M.D., Miller, L.K. Nature (1991) [Pubmed]
  9. A two-edged role for the transposable element Kiddo in the rice ubiquitin2 promoter. Yang, G., Lee, Y.H., Jiang, Y., Shi, X., Kertbundit, S., Hall, T.C. Plant Cell (2005) [Pubmed]
  10. The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1. Sakata, Y., Arima, K., Takai, T., Sakurai, W., Masumoto, K., Yuyama, N., Suminami, Y., Kishi, F., Yamashita, T., Kato, T., Ogawa, H., Fujimoto, K., Matsuo, Y., Sugita, Y., Izuhara, K. J. Biol. Chem. (2004) [Pubmed]
  11. Guanine levels in house dust as a means of estimating the mite population. Yokoyama, H., Matsuki, H., Misawa, K., Takaoka, M., Kasuga, H. Tokai J. Exp. Clin. Med. (1990) [Pubmed]
  12. IgE reactivity from serum of Blomia tropicalis allergic patients to the recombinant protein Blo t 1. Fonseca Fonseca, L., Díaz, A.M. Puerto Rico health sciences journal. (2003) [Pubmed]
  13. Acaricidal activity of Cnidium officinale rhizome-derived butylidenephthalide against Tyrophagus putrescentiae (Acari: Acaridae). Kwon, J.H., Ahn, Y.J. Pest Manag. Sci. (2003) [Pubmed]
  14. Treatment of perennial allergic rhinitis with cetirizine. Amat, P., Novella, A., Romá, J., Valero, A., Lluch, M., Malet, A. Allergologia et immunopathologia. (1992) [Pubmed]
  15. Can androgen deficiency promote an outbreak of psoroptic mange mites in male deer? Bubenik, G.A. J. Wildl. Dis. (1989) [Pubmed]
  16. Crusted scabies: A molecular analysis of Sarcoptes scabiei variety hominis populations from patients with repeated infestations. Walton, S.F., McBroom, J., Mathews, J.D., Kemp, D.J., Currie, B.J. Clin. Infect. Dis. (1999) [Pubmed]
  17. Effect of ivermectin on the control of ear mites (Psoroptes cuniculi) in naturally infested rabbits. Bowman, D.D., Fogelson, M.L., Carbone, L.G. Am. J. Vet. Res. (1992) [Pubmed]
  18. Susceptibility of northern fowl mites in North Carolina to five acaricides. Arthur, F.H., Axtell, R.C. Poult. Sci. (1983) [Pubmed]
  19. Molecular approach in spider mites (Acari: Tetranychidae): preliminary data on ribosomal DNA sequences. Navajas, M., Cotton, D., Kreiter, S., Gutierrez, J. Exp. Appl. Acarol. (1992) [Pubmed]
  20. Effects of terbuthylazine on soil fauna and decomposition processes. Salminen, J., Eriksson, I., Haimi, J. Ecotoxicol. Environ. Saf. (1996) [Pubmed]
  21. Preliminary evidence for 'aberrant' expression of the leukocyte integrin LFA-1 (CD11a/CD18) on conjunctival epithelial cells of patients with mite allergy. Pesce, G., Ciprandi, G., Buscaglia, S., Fiorino, N., Salmaso, C., Riccio, A.M., Canonica, G.W., Bagnasco, M. Int. Arch. Allergy Immunol. (2001) [Pubmed]
  22. Inhibition of chemical mediator release from human leukocytes and lung in vitro by a novel antiallergic agent, KB-2413. Nishimura, N., Ito, K., Tomioka, H., Yoshida, S. Immunopharmacology and immunotoxicology. (1987) [Pubmed]
  23. Altered physiology in worker honey bees (Hymenoptera: Apidae) infested with the mite Varroa destructor (Acari: Varroidae): a factor in colony loss during overwintering? Amdam, G.V., Hartfelder, K., Norberg, K., Hagen, A., Omholt, S.W. J. Econ. Entomol. (2004) [Pubmed]
  24. Cross-reactivity studies of a new group 2 allergen from the dust mite Glycyphagus domesticus, Gly d 2, and group 2 allergens from Dermatophagoides pteronyssinus, Lepidoglyphus destructor, and Tyrophagus putrescentiae with recombinant allergens. Gafvelin, G., Johansson, E., Lundin, A., Smith, A.M., Chapman, M.D., Benjamin, D.C., Derewenda, U., van Hage-Hamsten, M. J. Allergy Clin. Immunol. (2001) [Pubmed]
  25. A double-blind, placebo controlled trial of solidified benzyl benzoate applied in dwellings of asthmatic patients sensitive to mites: clinical efficacy and effect on mite allergens. Dietemann, A., Bessot, J.C., Hoyet, C., Ott, M., Verot, A., Pauli, G. J. Allergy Clin. Immunol. (1993) [Pubmed]
  26. Time course of onset of sensitization to common and occupational inhalants in apprentices. Nguyen, B., Ghezzo, H., Malo, J.L., Gautrin, D. J. Allergy Clin. Immunol. (2003) [Pubmed]
  27. The isolation and characterization of a novel collagenolytic serine protease allergen (Der p 9) from the dust mite Dermatophagoides pteronyssinus. King, C., Simpson, R.J., Moritz, R.L., Reed, G.E., Thompson, P.J., Stewart, G.A. J. Allergy Clin. Immunol. (1996) [Pubmed]
  28. Mite asthma in childhood: a study of the relationship between exposure to house dust mites and disease activity. Kivity, S., Solomon, A., Soferman, R., Schwarz, Y., Mumcuoglu, K.Y., Topilsky, M. J. Allergy Clin. Immunol. (1993) [Pubmed]
  29. In vitro diagnosis of farmers' IgE-mediated allergy by Phadiatop and three new multiallergen RAST analyses. van Hage-Hamsten, M., Johansson, S.G. Allergy (1993) [Pubmed]
  30. Production of IL-1 alpha and IL-1 beta by human skin equivalents parasitized by Sarcoptes scabiei. Arlian, L.G., Vyszenski-Moher, D.L., Rapp, C.M., Hull, B.E. J. Parasitol. (1996) [Pubmed]
  31. Of mites and zen: expression studies in a chelicerate arthropod confirm zen is a divergent Hox gene. Telford, M.J., Thomas, R.H. Dev. Genes Evol. (1998) [Pubmed]
  32. High temperatures eliminate Wolbachia, a cytoplasmic incompatibility inducing endosymbiont, from the two-spotted spider mite. van Opijnen, T., Breeuwer, J.A. Exp. Appl. Acarol. (1999) [Pubmed]
  33. Deposition of IgD, alpha-1-antitrypsin and alpha-1-antichymotrypsin on Demodex folliculorum and D. brevis infesting the pilosebaceous unit. Tsutsumi, Y. Pathol. Int. (2004) [Pubmed]
  34. Specific depletion of the house dust mite allergen Der p 1 cereal flour prolamins. Barber, D., Pernas, M., Chamorro, M.J., Carreira, J., Arteaga, C., Sánchez-Monge, R., Polo, F., Salcedo, G. J. Allergy Clin. Immunol. (1996) [Pubmed]
  35. Susceptibility of populations of Banks grass mites (Acari: Tetranychidae) suspected of developing bifenthrin resistance from three maize fields. Bynum, E.D., Archer, T.L. Exp. Appl. Acarol. (2002) [Pubmed]
  36. A technique for quantitative evaluation of ectoparasitic mites and insects of domestic animals. Mumcuoglu, K.Y. Exp. Appl. Acarol. (1990) [Pubmed]
  37. Mechanisms of resistance to organophosphates in Tetranychus urticae (Acari: Tetranychidae) from Greece. Tsagkarakou, A., Pasteur, N., Cuany, A., Chevillon, C., Navajas, M. Insect Biochem. Mol. Biol. (2002) [Pubmed]
  38. Epidemiological study of mites and guanine in house dust. Yokoyama, H., Matsuki, H., Takaoka, M., Sugiuchi, M., Kasuga, H. Tokai J. Exp. Clin. Med. (1990) [Pubmed]
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