Disease relevance of Fasciolin

• Context: We report on two patients, a 23-year-old man and a 24-year-old man, who had chemical pneumonitis and respiratory distress after inhaling hexachloroethane/zinc oxide (HC/ZnO) smoke during military training [1].
• The effects of inhaled zinc oxide/hexachloroethane smoke (11,580 mg x min/m3) and intratracheally instilled zinc chloride (2.5 mg/kg body weight) have been studied in rat lung [2].
• The results indicate that smoke condensate from titanium dioxide/hexachloroethane mixtures contains unidentified compound(s) that may be considered mutagenic in the Salmonella assay [3].
• The repeated dose toxicity of a zinc oxide/hexachloroethane smoke [4].
• The results indicated that occupational exposure to hexachlorobenzene and octachlorostyrene in aluminum degassing with hexachloroethane may affect porphyrin metabolism in a manner consistent with early secondary coproporphyrinuria-the first recognized step in the development of chronic hepatic porphyria [5].

High impact information on Fasciolin

• Partial oxidation of the tetraalkyltetraindium(I) compound In4[C(SiMe3)3]4] 1 with halogen donors such as 1,2-dibromoethane and hexachloroethane or with mixtures of bromine and aluminum tribromide afforded novel alkylindium halides in which the indium atoms still possess unusually low oxidation states [6].
• Case report: hexachloroethane smoke inhalation: a rare cause of severe hepatic injuries [1].
• CYP101 (cytochrome P450cam) catalyses the oxidation of camphor but has also been shown to catalyse the reductive dehalogenation of hexachloroethane and pentachloroethane [7].
• The hexachloroethane dehalogenation activity of CYP101 has been investigated by mutagenesis [7].
• Increasing the active-site hydrophobicity by the Y96A and Y96F mutations strengthened hexachloroethane binding but decreased the rate of reaction [7].

Biological context of Fasciolin

• Trout were exposed to 1,1,2,2-tetrachloroethane, pentachloroethane, and hexachloroethane in fish respirometer-metabolism chambers to assess the kinetics of chemical accumulation in arterial blood and chemical extraction efficiency from inspired water [8].
• Chloroethane, 1,1- and 1,2-dichloroethane, 1,1,1,2- and 1,1,2,2-tetrachloroethane, hexachloroethane and tetrachloroethylene were all negative in the assay conducted in the absence of an exogenous metabolic activation system [9].
• After treatment with hexachlorethane, Fasciola hepatica-infected cows had a significant (P = 0.05) average daily milk yield increase (90 to 120 days after treatment) of + 4.2 kg/day (+ 5.0 kg/day for single treatment and + 4.0 kg/day for double treatment) over daily yields of the previous lactation [10].
• Biological monitoring of hexachloroethane [11].
• Subchronic oral toxicity, tissue distribution and clearance of hexachloroethane in the rat [12].

Anatomical context of Fasciolin

• A small group (n = 12) of military white smoke munition workers provided blood plasma during a production break (S I) and after five weeks' production (S II) of a hexachloroethane (HCE)/titanium dioxide formula [11].

Associations of Fasciolin with other chemical compounds

• In the present study, we examined whether or not a recombinant strain of Saccharomyces cerevisiae that expresses rat liver cytochrome P450 1A2 (P450 1A2) wild-type and mutant proteins can efficiently catalyze oxidative and reductive dehalogenations of trichloroethylene, pentachloroethane, and hexachloroethane [13].
• The method is illustrated using the responses of Tradescantia exposed to a hexachloroethane/zinc chloride aerosol for 30 min at 50 and 100 m [14].

References