Disease relevance of oxytetracycline

• Oxytetracycline (OTC) is a 19-carbon polyketide antibiotic made by Streptomyces rimosus [1].
• The October 2004 campaign showed an enrichment of OA- and OTC-resistant Aeromonas immediately downstream of the fish farms and a wastewater treatment plant [2].
• The acute toxicities (48-h EC50 value, mg/l) in decreasing order were OA (4.6), TI (40), SU (221), ST (487), TY (680) and OTC (approximately 1000) [3].
• Experimental results of the model showed that, whereas oxytetracycline (OTC) significantly (P less than 0.05) decreased the duration of shedding of OTC-sensitive Salmonella, it significantly increased the duration of shedding of OTC-resistant Salmonella [4].
• CONCLUSION: These results suggest that OT and CP may be used as effective sclerosing agents for pleurodesis in the control of pleural effusions associated with MPM, without major side effects [5].

High impact information on oxytetracycline

• Labelling experiments revealed that a low level of otc ACP expressed prior to induction was produced mainly as active holo-protein, while post-induction 15N-labelled protein was almost exclusively in the apo-ACP form [6].
• A method of modified integrated pulsed amperometric detection with multicycle step waveform (Multi-IPAD) following high-performance liquid chromatography (HPLC) was applied for the determination of tetracyclines (TCs) including dimethyltetracycline (DMTC), oxytetracycline (OTC) and tetracycline (TC) [7].
• Conclusions: Aeromonas could be valuable indicators of OA, OTC and FC resistance in the freshwater environment [2].
• The variation increased by almost two orders of magnitude for OTC and TYL when pH was artificially adjusted [8].
• It is concluded that the T cell blast is the target for OxyTC [9].

Chemical compound and disease context of oxytetracycline

• In the current studies, we tested OTC and two other antibiotics (tylosin and lincomycin, candidate compounds for use in honey bee colonies) in a powdered sugar carrier for larval toxicity [10].

Biological context of oxytetracycline

• Finally, the bioavailability of OTC CF = 92.0+/-22.0 and LA= 78.0+/-23.0% was suitable for its usage by the IM route in lactating goats [11].
• No M-S9 protein binding of OTC was found [12].
• Other skeletal muscles studied had low and variable activities which were not significantly increased by cold acclimation or by cold plus OTC treatment [13].
• The results indicate that OTC transport in the environment will depend heavily on soil pH and composition and have implications for the development of bacterial antibiotic resistance [14].
• Radiography, histology, oxytetracycline (OTC) fluorescence labelling and microradiography were used [15].

Anatomical context of oxytetracycline

• It is reported here that the tetracycline analogue oxytetracycline (OxyTC) interferes with the mitogenic response of chicken leukocytes [9].

Associations of oxytetracycline with other chemical compounds

• Water hyacinths were treated with an antibiotic, oxytetracycline (OTC), to remove most rhizospheric bacteria of plant roots [16].
• A statistical analysis of the results obtained by these agents have demonstrated that OT (30 days, 81%; 90 days, 76.2%) and CP (30 days, 86.2%; 90 days, 79.3%) led to a significantly higher rate of successful pleurodesis as compared to NM (30 days, 48.2%; 90 days, 41.3%; p <0.05) [5].
• The IS-S9 protein binding of SP (60.4%) was very much higher than those of OTC (0.8%), SDD (4.1%), SMM (4.0%) and SQ (12.3%) (P < 0.01) [12].
• Studies show that OTC binding to fused quartz, methyl ester, carboxylic acid, and alkyl interfaces is fully reversible and highly dependent on solution pH, with appreciable adsorption occurring only at pH 8 [14].

Analytical, diagnostic and therapeutic context of oxytetracycline

• OTC treatment improved the phagocytic index of groupers subjected to caudal vessel puncture, but the phagocytic index was lower than that of groupers subjected to cannulation [17].
• OTC or CTC.HCl was separated from coexisting drugs and detected by thin-layer chromatography, then quantitated microbiologically by the agar diffusion method [18].
• As judged by histologic microradiographic, and OTC-labeling studies, 19 of 24 osteotomies were healing normally; after six weeks of follow-up examination, union of 11 of 14 osteotomies was observed on radiographs [19].
• The quantification of OTC was performed by HPLC and the plasma activities of CK and LDH enzymes were determined by spectrophotometry [11].
• RESULTS: The OTC concentration exceeded the maximum residue limit in kidney in animals slaughtered 21 days after treatment, which is the prescribed withholding period [20].

References