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Chemical Compound Review

Magnum     5-amino-4-chloro-2-phenyl- pyridazin-3-one;...

Synonyms: BAS 483H, AC1O54ZA, 50641-63-9
 
 
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Disease relevance of Magnum

  • The experience in consecutive procedures with 800 recanalization attempts of chronic total coronary occlusions using the Magnum wire was analyzed from a prospectively constituted computerized database [1].
  • A fatal gunshot wound to the thorax from a .357 Magnum revolver is reported [2].
  • In conclusion, Magnum wire is a feasible tool for angioplasty of total occlusions and severe stenoses [3].
  • OPUS OV, the tumour marker assay for the ovarian cancer antigen CA 125 is an ELISA that was developed for the family of fully automated random-access analyzers, OPUS, OPUS Plus and OPUS I Magnum [4].
  • Six patients per group had myocardial infarction of whom two in group Magnum and one in group Standard developed a Q-wave [5].
 

High impact information on Magnum

  • All occlusions were reached (in 23 right, 18 left anterior descending, 8 left circumflex coronary arteries and 1 diagonal branch) and 30 (60%) were recanalized (1 reoccluded during the procedure, and in 3 patients the Magnum wire did not completely cross the occlusion but enabled the previously impossible passage of a conventional wire) [6].
  • Regardless of needle size (14-20-gauge), breast biopsies should be routinely performed with automated long-throw side-notch guns (Acecut, Asap, Biopty, Magnum) [7].
  • Five alfalfa varieties (Alfagraze, Apollo Supreme Cimarron, Crockett, and Magnum III) and three bermudagrass varieties (Coastal, Tifton-78, and Tifton-85) were collected at different stages of maturity [8].
  • In the second in vivo study, we found a substantial difference in detection of cTnI by the Opus Magnum and ACCESS assays [9].
  • Integrating protein structures and precomputed genealogies in the Magnum database: examples with cellular retinoid binding proteins [10].
 

Biological context of Magnum

 

Anatomical context of Magnum

  • The two oviduct segments, magnum (M) and isthmus plus shell gland (IS), were collected [12].
  • This comparative study shows that cranio-cervical decompression with extreme lateral resection of the posterior rim of Foramen Magnum out to the level of the occipital condyles on either side, associated with an enlargement duroplasty with preservation of the arachnoid membrane, achieved the best results with minimal complications and side-effects [13].
  • Inbred Magnum guinea pigs were made uremic by ureteral ligation, and 1 day later injected with chromium (Cr)51-labeled syngeneic lymphocytes intravenously [14].
 

Associations of Magnum with other chemical compounds

 

Gene context of Magnum

  • Thus the Magnum Meier wire with Crag Fx wire catheter can be a useful tool for dilating totally occluded lesions in tortuous coronary arteries [16].
 

Analytical, diagnostic and therapeutic context of Magnum

  • The data confirm that the Magnum wire, generally used as a primary intervention for occlusive angioplasty at our centers, is competitive with conventional systems in this setting [1].
  • The Magnum wire for percutaneous coronary balloon angioplasty in 723 patients [17].
  • The Magnum deliverables include 1) multiple sequence alignments, 2) mapping of alignment sites to crystal structure sites, 3) phylogenetic trees, 4) inferred ancestral sequences at internal tree nodes, and 5) amino acid replacements along tree branches [10].
  • METHODS: A modified Feeney's TBI model was created in 48 adult rats. rMSCs were harvested from 3-month-old rats, and injected into Cistern Magnum in 24 rats subjected to TBI (Group cell transplantation) [11].
  • CONCLUSIONS: rMSCs transplantation via Cistern Magnum in rats subjected to traumatic brain injury can enhance expressions of local brain NGF and BDNF to a certain extent [11].

References

  1. Magnum wire for percutaneous coronary balloon angioplasty in 800 total chronic occlusions. Allemann, Y., Kaufmann, U.P., Meyer, B.J., Gunnes, P., Urban, P., Mülhauser, B., Dorsaz, P.A., Meier, B. Am. J. Cardiol. (1997) [Pubmed]
  2. Who fired the gun? A casuistic contribution to the differentiation between self-inflicted and non-self-inflicted gunshot wounds. Karger, B., DuChesne, A. Int. J. Legal Med. (1997) [Pubmed]
  3. Magnum wire for angioplasty of total and non-total coronary lesions. Gunnes, P., Meyer, B.J., Kessler, B., Mülhauser, B., Meier, B. International journal of cardiology. (1997) [Pubmed]
  4. A new tumour marker assay for ovarian cancer on the OPUS immunoassay system. Molz, P., Teuter, C., Schelp, C., Amann, E. Anticancer Res. (1997) [Pubmed]
  5. Magnum system for routine coronary angioplasty: a randomized study. Nukta, E.D., Meier, B., Urban, P., Muller, T., Dorsaz, P.A., Favre, J. Catheterization and cardiovascular diagnosis. (1992) [Pubmed]
  6. Magnum wire for balloon recanalization of chronic total coronary occlusions. Meier, B., Carlier, M., Finci, L., Nukta, E., Urban, P., Niederhauser, W., Favre, J. Am. J. Cardiol. (1989) [Pubmed]
  7. Randomized in vitro and in vivo evaluation of different biopsy needles and devices for breast biopsy. Helbich, T.H., Rudas, M., Böhm, G., Huber, S., Wagner, T., Taucher, S., Wolf, G., Mostbeck, G.H. Clinical radiology. (1999) [Pubmed]
  8. Malate content of forage varieties commonly fed to cattle. Callaway, T.R., Martin, S.A., Wampler, J.L., Hill, N.S., Hill, G.M. J. Dairy Sci. (1997) [Pubmed]
  9. Positive interference from contrast media in cardiac troponin I immunoassays. Lin, C.T., Lee, H.C., Voon, W.C., Yen, H.W., Tang, M.H., Chin, T.T., Chen, W.R., Chien, W.T., Lai, W.T., Sheu, S.H. Kaohsiung J. Med. Sci. (2006) [Pubmed]
  10. Integrating protein structures and precomputed genealogies in the Magnum database: examples with cellular retinoid binding proteins. Bradley, M.E., Benner, S.A. BMC Bioinformatics (2006) [Pubmed]
  11. Upregulated gene expression of local brain-derived neurotrophic factor and nerve growth factor after intracisternal administration of marrow stromal cells in rats with traumatic brain injury. Hu, D.Z., Zhou, L.F., Zhu, J., Mao, Y., Wu, X.H. Chinese journal of traumatology = Zhonghua chuang shang za zhi / Chinese Medical Association. (2005) [Pubmed]
  12. Binding profile of spiramycin to oviducal proteins of laying hens. Furusawa, N. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine. (2000) [Pubmed]
  13. Cranio-cervical decompression for Chiari type I-malformation, adding extreme lateral foramen magnum opening and expansile duroplasty with arachnoid preservation. Technique and long-term functional results in 44 consecutive adult cases -- comparison with literature data. Sindou, M., Chávez-Machuca, J., Hashish, H. Acta neurochirurgica. (2002) [Pubmed]
  14. Lymphocyte kinetics in acute uremia: redistribution of circulating lymphocytes to the bone marrow. Slavin, R.G., Hutcheson, P.S., Rohrer, S.D. Int. Arch. Allergy Appl. Immunol. (1982) [Pubmed]
  15. Performance evaluation of a new chemiluminescent cardiac troponin I assay. Dasgupta, A., Chow, L., Nazareno, L., Tso, G., Datta, P. J. Clin. Lab. Anal. (2000) [Pubmed]
  16. Magnum Meier wires with Crag Fx wire catheter for total occlusive coronary arteries. Kitazume, H., Kubo, I., Iwama, T. Catheterization and cardiovascular diagnosis. (1997) [Pubmed]
  17. The Magnum wire for percutaneous coronary balloon angioplasty in 723 patients. Jaup, T., Allemann, Y., Urban, P., Dorsaz, P.A., Chatelain, P., Brzostek, T., Verine, V., Rutishauser, W., Meier, B. The Journal of invasive cardiology. (1995) [Pubmed]
 
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