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Chemical Compound Review

Ribastamin     5-amino-2-(aminomethyl)-6- [4,6-diamino-2...

Synonyms: Xylostacin, Xylostasin, AG-J-89622, SureCN4318426, CCG-102472, ...
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Disease relevance of ribostamycin


High impact information on ribostamycin


Chemical compound and disease context of ribostamycin


Biological context of ribostamycin

  • The RSM resistance gene showed no homology to plasmid pSF733 of S. ribosidificus SF733, but hybridized to PstI or BclI digested total DNA of S. ribosidificus SF733 [12].
  • Glycosylation at the 5 position with various pentofuranose derivatives yielded after deprotection of the 6a approximately i ribostamycin related aminoglycoside [13].

Anatomical context of ribostamycin


Associations of ribostamycin with other chemical compounds


Gene context of ribostamycin

  • The binding affinity of ribostamycin to purified bovine PDI was determined by the Biacore system, which gave a K(D) value of 3.19 x 10(-4) M [20].
  • When a dose of 40 mg/kg per day was administered intramuscularly to Fischer rats for 14 days, ribostamycin caused little change of parameters in urine volume, urine osmolality, urine protein, maltase and beta 2-microglobulin [14].

Analytical, diagnostic and therapeutic context of ribostamycin


  1. Nucleotide sequence of the ribostamycin phosphotransferase gene and of its control region in Streptomyces ribosidificus. Hoshiko, S., Nojiri, C., Matsunaga, K., Katsumata, K., Satoh, E., Nagaoka, K. Gene (1988) [Pubmed]
  2. Anaphylaxis due to ribostamycin. Lee, Y.D., Cho, Y., Han, M.S. Allergy (2004) [Pubmed]
  3. Erythroderma due to ribostamycin. Puig, L.L., Abadias, M., Alomar, A. Contact Derm. (1989) [Pubmed]
  4. Animal studies on the reduction of aminoglycoside-induced nephrotoxicity by D-glucaro-1,5-lactam. Marre, R., Müller, W., Sack, K. Infection (1983) [Pubmed]
  5. Comparative antimicrobial activities of ribostamycin, gentamicin, ampicillin and lincomycin in vitro and in vivo. Inouye, S., Watanabe, T., Kitasato, I. Drugs under experimental and clinical research. (1989) [Pubmed]
  6. Structural rearrangements of HIV-1 Tat-responsive RNA upon binding of neomycin B. Faber, C., Sticht, H., Schweimer, K., Rösch, P. J. Biol. Chem. (2000) [Pubmed]
  7. Pharmacokinetics of ribostamycin in paediatric patients. Zhou, S.L., Shen, G., Zhong, H.F. Clinical pharmacokinetics. (1992) [Pubmed]
  8. Structure-function relationships for the effects of various aminoglycoside antibiotics on dispersed bovine parathyroid cells. Katz, C.L., Butters, R.R., Chen, C.J., Brown, E.M. Endocrinology (1992) [Pubmed]
  9. Ribostamycin, as an intermediate in the biosynthesis of neomycin. Baud, H., Betencourt, A., Peyre, M., Penasse, L. J. Antibiot. (1977) [Pubmed]
  10. Bioconversion of ribostamycin (SF-733). III. Formation, structure and synthesis of 3-N-carboxymethyl ribostamycin. Kojima, M., Inouye, S., Nida, T. J. Antibiot. (1975) [Pubmed]
  11. Comparative study by scanning electron microscopy on vestibular toxicities of dibekacin, ribostamycin, and other aminoglycoside antibiotics in guinea pigs. Sato, K., Saito, T., Matsuhira, T. International journal of clinical pharmacology, therapy, and toxicology. (1983) [Pubmed]
  12. Cloning of antibiotic-resistance genes in Streptomyces. Murakami, T., Nojiri, C., Toyama, H., Hayashi, E., Katumata, K., Anzai, H., Matsuhashi, Y., Yamada, Y., Nagaoka, K. J. Antibiot. (1983) [Pubmed]
  13. Synthesis of pseudotrisaccharides related to ribostamycin. Girodeau, J.M., Pineau, R., Masson, M., Le Goffic, F. J. Antibiot. (1984) [Pubmed]
  14. Comparative nephrotoxicity of ribostamycin and gentamicin in rats evaluated by urinalysis. Kitasato, I., Niizato, T., Inouye, S. Drugs under experimental and clinical research. (1989) [Pubmed]
  15. Ototoxic effects of a pseudodisaccharide aminoglycoside antibiotic, dactimicin, on the inner ears of guinea pigs. Yokota, M., Sakamoto, K., Inouye, S., Akiyoshi, M., Kitasato, I. Chemotherapy. (1989) [Pubmed]
  16. Analysis of the phamacokinetics of ribostamycin in serum and perilymph of guinea pigs after single and multiple doses. Harpur, E.S., Gonda, I. British journal of audiology. (1982) [Pubmed]
  17. Identification of dekamycin antibiotics. Van, T.D., Khac, D.D., Fetizon, M., Tabet, J.C., Le Beyec, Y., Quyen, T.C. J. Chromatogr. (1988) [Pubmed]
  18. Inhibitory effects of aminoglycoside antibiotics on reduction of cytochrome c from Candida krusei. Yamabe, S. Chemotherapy. (1980) [Pubmed]
  19. Comparative evaluation of the neuromuscular blocking activity of three new aminoglycoside antibiotics in rats. Renna, G., Siro-Brigiani, G., Cuomo, V. Toxicol. Lett. (1981) [Pubmed]
  20. Ribostamycin inhibits the chaperone activity of protein disulfide isomerase. Horibe, T., Nagai, H., Sakakibara, K., Hagiwara, Y., Kikuchi, M. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  21. Pharmacokinetics of ribostamycin in healthy volunteers and patients with impaired renal function. Yamasaku, F., Suzuki, Y., Umemura, K. The Japanese journal of antibiotics. (1980) [Pubmed]
  22. In vitro activity of ribostamycin against Prototheca sp. Casal, M., Gutierrez Aroca, J. Mycopathologia (1983) [Pubmed]
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