Disease relevance of ribostamycin

• The nucleotide sequence of an aminoglycoside phosphotransferase gene (rph) from Streptomyces ribosidificus (a ribostamycin producer) was determined [1].
• Anaphylaxis due to ribostamycin [2].
• Erythroderma due to ribostamycin [3].
• It did not impair the therapeutic efficacy of ribostamycin in the experimental treatment of acute pyelonephritis in rats [4].
• Ribostamycin showed comparable or slightly weaker in vitro activity than the reference antibiotics against Gram-positive bacteria [5].

High impact information on ribostamycin

• NMR spectroscopy indicated that the aminoglycosides neomycin B and ribostamycin bind to TAR and that neomycin is able to inhibit Tat binding to TAR [6].
• Pharmacokinetics of ribostamycin in paediatric patients [7].
• Gentamicin-C, paromomycin, and tobramycin, which have five amino groups, were less potent, with IC50 values of 4 x 10(-4), 10(-3), and 3.3 x 10(-4) M, respectively, while gentamicin-B, kanamycin, and ribostamycin, with four amino groups, were least potent (respective IC50 values, 2.0, 2.9, and 3 x 10(-3) M) [8].
• There were significant positive correlations between Cmax, AUC and ribostamycin dosage (p less than 0.01) [7].
• Nucleotide sequence of the ribostamycin phosphotransferase gene and of its control region in Streptomyces ribosidificus [1].

Chemical compound and disease context of ribostamycin

• A mutant of a neomycin-producting Streptomyces fradiae was found which synthesizes ribostamycin instead of neomycin [9].
• Against Gram-negative bacteria, ribostamycin was less active than gentamicin, but comparable to or more active than ampicillin [5].
• A new inactivated product of ribostamycin (SF-733), 3-N-carboxymethyl ribostamycin, was obtained from the broth of Streptomyces ribosidificus which was grown on a medium containing D-xylose [10].
• Comparative study by scanning electron microscopy on vestibular toxicities of dibekacin, ribostamycin, and other aminoglycoside antibiotics in guinea pigs [11].
• The vestibular toxicities of dibekacin, ribostamycin, gentamicin, and streptomycin were compared in guinea pigs [11].

Biological context of ribostamycin

• The RSM resistance gene showed no homology to plasmid pSF733 of S. ribosidificus SF733, but hybridized to PstI or BclI digested total DNA of S. ribosidificus SF733 [12].
• Glycosylation at the 5 position with various pentofuranose derivatives yielded after deprotection of the 6a approximately i ribostamycin related aminoglycoside [13].

Anatomical context of ribostamycin

• Histopathological observations of the kidney specimens of rats given 40 mg/kg per day showed no histological damage with ribostamycin except for a slight increase and enlargement of lysosomes of the proximal epithelial cells [14].
• A lymphocyte transformation test was positive for ribostamycin and tobramycin, but not for gentamycin [3].
• Based on these observations, it is concluded that the ototoxicity of dactimicin on the inner ear of guinea pigs is the same as or a little stronger than that of ribostamycin, weaker than or the same as that of astromicin and weaker than amikacin [15].
• The area under the ribostamycin concentration in perilymph against time curve was also reduced after multiple dosing [16].

Associations of ribostamycin with other chemical compounds

• Mass spectrometry (252Cf plasma desorption mass spectrometry, fast atom bombardment) for the analysis of N-acetyldekamycins (neomycin B, neomycin C, neamine and ribostamycin) was mainly used to confirm the molecular weight of a structure deduced by 1H and 13C NMR analyses [17].
• The antimicrobial activity of ribostamycin, a unique aminoglycoside antibiotic possessing a neutral sugar component, was compared with those of gentamicin, ampicillin and lincomycin in vitro and in vivo [5].
• Comparative antimicrobial activities of ribostamycin, gentamicin, ampicillin and lincomycin in vitro and in vivo [5].
• Five aminoglycoside antibiotics (AGAs)--kanamycin (KM), bekamycin (AKM), dibekacin (DKB), ribostamycin (RSM) and paromomycin (PRM)--were studied for their effects on the nonenzymic reduction of cytochrome c by FeSO4 (Yamabe's system) [18].
• Tobramycin, amikacin and ribostamycin produced dose-dependent neuromuscular blockade of the diaphragm twitches [19].

Gene context of ribostamycin

• The binding affinity of ribostamycin to purified bovine PDI was determined by the Biacore system, which gave a K(D) value of 3.19 x 10(-4) M [20].
• When a dose of 40 mg/kg per day was administered intramuscularly to Fischer rats for 14 days, ribostamycin caused little change of parameters in urine volume, urine osmolality, urine protein, maltase and beta 2-microglobulin [14].

Analytical, diagnostic and therapeutic context of ribostamycin

• In the present studies, the pharmacokinetic behavior of ribostamycin was studied in 5 healthy adult volunteers receiving different doses (0.5 g, 1.0 g and 1.5 g) by intramuscular injection, and 0.5 g by intravenous drip infusion [21].
• The in vitro activity of ribostamycin against algae of the genus Prototheca was evaluated by minimum inhibitory concentration (MIC) studies on solid media [22].

References