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Chemical Compound Review:

Lipitor calcium(3R,5R)-7-[2-(4- fluorophenyl)-3...

Synonyms: Totalip, Sortis, AC1LCVLW, CHEBI:2911, AKOS015994661, ...

This record was replaced with 60823.

Brumeanu, T.D. et al., Frishman, W.H. et al., Lee, T.H., Mendoza, L. et al., Nash, M.S. et al., et al.

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Disease relevance of Cardyl

Atorvastatin (Lipitor) was tested in chronic and relapsing experimental autoimmune encephalomyelitis, a CD4(+) Th1-mediated central nervous system (CNS) demyelinating disease model of multiple sclerosis [1].
We assessed the chemopreventive efficacy of atorvastatin (Lipitor) and celecoxib individually or in combination in an animal model of familial adenomatous polyposis [2].
We also present data from our laboratories showing for the first time that in a double transgenic mouse model for autoimmune diabetes, atorvastatin (lipitor) prevented the onset of disease when administered in the neonatal period, and stabilized the glucose levels when administered in mice developing a mild form of diabetes [3].
Avascular necrosis prevention with lipitor in lupus erythematosus [4].
BACKGROUND/OBJECTIVE: Effects of atorvastatin (Lipitor) drug monotherapy (10 mg daily) on fasting blood lipid profiles and cardiovascular disease (CVD) risks were examined for a single subject with C5-C6 tetraplegia [5].

High impact information on Cardyl

An overview of the clinical safety profile of atorvastatin (lipitor), a new HMG-CoA reductase inhibitor [6].
Our results indicate that Lipitor treatment markedly attenuates A beta deposition in this animal model [7].
The aim of this study was to compare the bioavailability of two atorvastatin formulations (Divator Drogsan Pharmaceuticals, Ankara, Turkey, as the test formulation, and Lipitor, Pfizer Ireland Pharmaceuticals, Dublin, Ireland, as the reference formulation) in 52 healthy volunteers [8].
These toxicities can be managed with dose attenuation or addition of atorvastatin (Lipitor, Pfizer) or fenofibrate (TriCor, Abbott Laboratories) [9].
Combination therapy of amlodipine besylate (Norvasc, Pfizer Ltd) with atorvastatin calcium (Lipitor, Pfizer Ltd), marketed as Caduet (Pfizer Ltd) is the first dual-therapy compound designed to treat hypertension and/or angina and dyslipidemia concurrently with a single daily pill in the full range of dosing combinations [10].

Associations of Cardyl with other chemical compounds

By the way, doctor. I'm 72, with no history of heart trouble. But my cholesterol is in the 220s, and I have been taking Lipitor for three years. I am thinking about buying a home defibrillator, primarily for myself but also for any emergency (although my wife is 52 and in excellent health). What's your advice [11]?

References

The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Youssef, S., Stüve, O., Patarroyo, J.C., Ruiz, P.J., Radosevich, J.L., Hur, E.M., Bravo, M., Mitchell, D.J., Sobel, R.A., Steinman, L., Zamvil, S.S. Nature (2002) [Pubmed]
Chemoprevention of familial adenomatous polyposis by low doses of atorvastatin and celecoxib given individually and in combination to APCMin mice. Swamy, M.V., Patlolla, J.M., Steele, V.E., Kopelovich, L., Reddy, B.S., Rao, C.V. Cancer Res. (2006) [Pubmed]
Down-regulation of autoreactive T-cells by HMG CoA reductase inhibitors. Brumeanu, T.D., Goldstein, R., Casares, S. Clin. Immunol. (2006) [Pubmed]
Avascular necrosis prevention with lipitor in lupus erythematosus. Belmont, H.M., Lydon, E. Lupus (2005) [Pubmed]
Combined hyperlipidemia in a single subject with tetraplegia: ineffective risk reduction after atorvastatin monotherapy. Nash, M.S., Johnson, B.M., Jacobs, P.L. The journal of spinal cord medicine. (2004) [Pubmed]
An overview of the clinical safety profile of atorvastatin (lipitor), a new HMG-CoA reductase inhibitor. Black, D.M., Bakker-Arkema, R.G., Nawrocki, J.W. Arch. Intern. Med. (1998) [Pubmed]
Statin therapy for Alzheimer's disease: will it work? Petanceska, S.S., DeRosa, S., Olm, V., Diaz, N., Sharma, A., Thomas-Bryant, T., Duff, K., Pappolla, M., Refolo, L.M. J. Mol. Neurosci. (2002) [Pubmed]
Pharmacokinetic and bioequivalence testing of atorvastatin formulations in healthy male volunteers. Mendoza, L., Hajd??ch, M., Plausinaitis, R., Plat??lov??, V., Emritte, N., Svoboda, M. Die Pharmazie. (2006) [Pubmed]
Bexarotene: a clinical review. Farol, L.T., Hymes, K.B. Expert review of anticancer therapy. (2004) [Pubmed]
Amlodipine/atorvastatin: the first cross risk factor polypill for the prevention and treatment of cardiovascular disease. Frishman, W.H., Zuckerman, A.L. Expert review of cardiovascular therapy. (2004) [Pubmed]
By the way, doctor. I'm 72, with no history of heart trouble. But my cholesterol is in the 220s, and I have been taking Lipitor for three years. I am thinking about buying a home defibrillator, primarily for myself but also for any emergency (although my wife is 52 and in excellent health). What's your advice? Lee, T.H. Harvard health letter / from Harvard Medical School. (2003) [Pubmed]

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