Disease relevance of Defibrillators

• METHODS AND RESULTS: Twenty-one patients undergoing implantation of Medtronic PCD Jewel 7219D cardioverter/defibrillators because of ventricular tachycardia and/or VF were enrolled [1].
• Use of a defibrillator (implantable cardioverter-defibrillator, ICD) without stored electrograms among 81 patients precluded determination of the type of arrhythmia recurrence; thus these patients were censored at the time of ICD implantation [2].
• Nineteen consecutive patients with a nonischemic cardiomyopathy and a cardiac arrest who were treated with a defibrillator (Arrest Group) served as a control group [3].
• In the post-MI defibrillator (implantable cardioverter defibrillator [ICD]) trials, AVID (Antiarrhythmic Versus Implantable Defibrillator) and MUSTT (Multicenter Unsustained Tachycardia Trial), beta-adrenoceptor antagonist therapy was independently associated with improved overall survival [4].
• In one family, a member homozygous for Lys207Gln had cardiomyopathy complicated by left ventricular dilatation, systolic impairment, atrial fibrillation, and defibrillator interventions [5].

Psychiatry related information on Defibrillators

• There was no difference in BLS response time intervals or automatic external defibrillator (AED) use rates [6].

High impact information on Defibrillators

• Clinical and genetic risk stratification may lead to prospective trials of primary implantation of cardioverter defibrillators in people with hereditary cardiomyopathy [7].
• After February 1985, because the availability of the defibrillator was severely curtailed, patients who lost consciousness received treatment with amiodarone alone (group B) [8].
• Among the 201 ICDs with integrated bipolar sensing, 80 were connected to a CPI device (60 Ventak 1600-Endotak 60 series and 20 PRx II 1715-Endotak 70 series) and 121 to the Ventritex defibrillator (91 Endotak 60 series, 14 TVL systems, and 16 Endotak 70 series) [9].
• Nine patients are alive, 3 with implanted defibrillators and 6 treated with verapamil alone [10].
• The hermetically sealed defibrillator is encased in titanium, weighs 250 g and has a volume of 145 ml [11].

Chemical compound and disease context of Defibrillators

• In cardiac arrest survivors, an electrophysiological approach seems preferable to empiric amiodarone, together with implantation of a defibrillator, at least in those in whom inducible arrhythmias cannot be suppressed [12].
• Comparison of metoprolol and sotalol in preventing ventricular tachyarrhythmias after the implantation of a cardioverter/defibrillator [13].
• Propafenone is a new drug that has been shown to be efficacious in the therapy of supraventricular and ventricular arrhythmias, and is of potential use in patients with defibrillators [14].
• NYHA class, etiology of heart failure, therapy with angiotensin-converting enzyme inhibitors, amiodarone or beta-blockers, implanted defibrillator, and atrial fibrillation had no significant influence on QRS D [15].
• Effect of verapamil on prevention of atrial fibrillation in patients implanted with an implantable atrial defibrillator [16].

Biological context of Defibrillators

• CONCLUSIONS: The high incidence of appropriate defibrillator shocks and the association of recurrent syncope with ventricular arrhythmias support the treatment of patients with nonischemic cardiomyopathy, unexplained syncope and a negative electrophysiology test with an implantable defibrillator [3].
• BACKGROUND: Iodine 123 metaiodobenzylguanidine (MIBG) imaging and heart rate variability (HRV) analysis were compared in patients with an implantable cardioverter defibrillator (ICD) who did and did not receive defibrillator discharges [17].
• BLS performed by prehospital providers potentially includes artificial ventilations, chest compressions, and application of an automated external defibrillator (AED) [18].

Anatomical context of Defibrillators

• In 341 patients, CABG alone was performed, and 24 patients had combined procedures: 11 had CABG with mitral valve replacement, 9 had CABG with aortic valve replacement, 2 had CABG with repair of postinfarct ventricular septal defect, and 2 had CABG with automatic defibrillator implantation [19].
• Chronically implanted ventricular pacing and defibrillator (ICD) leads can adhere to the tricuspid valve [20].
• Use of conventional nondedicated hardware for biventricular pacer/defibrillator is feasible but should be considered only in patients with poor AV node function or less likely to require antitachycardic therapy, to avoid ICD double counting of ventricular sensed events and consequent high incidence of inappropriate therapies [21].
• We report a case of a 35-year-old woman with ARVD and a patent foramen ovale discovered after accidental placement of the defibrillator probe in the left ventricle [22].
• METHODS: Seven patients with ventricular tachycardia and/or ventricular fibrillation (VT/VF), associated with bradyanhythmia received implantation of a dual chamber pacemaker defibrillator, including 5 patients with coronary artery disease and 2 patients with dilated cardiomyopathy [23].

Associations of Defibrillators with chemical compounds

• A randomized trial comparing heparin initiation 6 h or 24 h after pacemaker or defibrillator implantation [24].
• We tested the hypothesis that adrenergic agents (epinephrine, norepinephrine, isoproterenol) and a calcium channel blocker (verapamil), when applied acutely, alter the duration of arrest following a defibrillator shock [25].
• Oral sotalol 171 +/- 58 mg was administered before and after device implantation in 25 patients receiving implanted defibrillators [26].
• A 78-year-old man with a transvenous cardioverter defibrillator system developed frequent shocks during oral procainamide therapy [27].
• Propofol reduces idiopathic prolonged QT interval and QT dispersion during implantation of cardioverter defibrillator [28].

Gene context of Defibrillators

• Automated external defibrillators: an update of additions to the ACLS algorithms [29].
• Fifteen patients undergoing defibrillator implantation were studied to compare the efficacy of the catheter with that of the superior vena cava spring (6.7 cm2, anode)-left ventricular patch (13.5 cm2, cathode) electrode system using truncated exponential waveforms with 60% tilt [30].
• CONCLUSIONS: Beta-blocker use was independently associated with improved survival in patients with VF or symptomatic VT who were not treated with specific antiarrhythmic therapy, but a protective effect was not prominent in patients already receiving amiodarone or a defibrillator [31].
• Release of neuron-specific enolase and s100 after implantation of cardioverters/defibrillators [32].
• Both devices (the Philips FR2 or the HS1) are used in public access defibrillator settings [33].

Analytical, diagnostic and therapeutic context of Defibrillators

• IMPLICATIONS: Halothane, isoflurane, and IV fentanyl added to N(2)O/oxygen-based general anesthesia similarly increase minimal defibrillation threshold energy requirements (DFT) during cardioverter defibrillator implantation in humans [34].
• Catheter ablation was performed in 51 patients (G1), map guided surgery in 147 (G2), and cardioverter defibrillator implantation (ICD) in 356 (G3) [35].
• Is dual defibrillator better than conventional DDD pacing in brady-tachy syndrome? Results of the ICARUS Trial (Internal Cardioversion Antitachypacing and Prevention: Resource Utilization Study) [36].
• Therefore, we recommend that the catheter be removed under ECG monitoring by experienced personnel, with lidocaine and a defibrillator available [37].
• Basic life support and emergency cardiovascular care guidelines, Part 2: Defibrillators [38].

References