Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

RIQIJXOWVAHQES-RSXZCOBQSA-N [(2R)-2,5,7,8-tetramethyl-2- [(4R,8R)-4,8...

Synonyms:

Mizutani, H. et al., Mori, Y. et al., Makishima, M. et al., Makishima, M. et al., Kawabata, H. et al., et al.

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Disease relevance of tretinoin tocoferil

Because tretinoin tocoferil was reported to induce neither retinoid-related toxicity nor teratogenicity, the therapeutic advantage of the use of it in treatment of myelomonocytic leukemia is suggested [1].
Recently, it has been reported that tretinoin tocoferil (TT), a synthesized ester-bond compound of all-trans-retinoic acid and alpha-tocopherol, accelerates the formation of granuloma and is effective in promoting experimental open skin wound healing [2].
Immunoreactive tenascin-C expressed in the proliferated deep dermal fibers of the SSc and hypertrophic scar lesions was markedly decreased compared with the level before the topical tocoretinate therapy [3].
Topical tocoretinate improved hypertrophic scar, skin sclerosis in systemic sclerosis and morphea [3].
Four patients with systemic scleroderma (SSc), 4 patients with morphea, and 4 patients with hypertrophic scar were treated with topical tocoretinate for 6 months to 3 years and studied clinically and histopathologically [3].

High impact information on tretinoin tocoferil

Tretinoin tocoferil increased NBT reduction in HL-60 cells treated with RA [1].
Tocoretinate inhibited the contraction of collagen gel matrices by human dermal fibroblasts with tenascin-C expression [4].
Tretinoin tocoferil stimulates the formation of granulation tissue in the ulcer, and enhances the migration of guinea pig macrophages and stimulates the proliferation of human skin fibroblasts [5].
Effects of tretinoin tocoferil on gene expression of the extracellular matrix components in human dermal fibroblasts in vitro [2].
Enhancement by tocoretinate of epidermal growth factor-induced DNA synthesis in human intestinal epithelial cells [6].

Analytical, diagnostic and therapeutic context of tretinoin tocoferil

Toxicity tests in animal models have shown that tretinoin tocoferil is at least 150 times less toxic than ATRA and does not induce teratogenesis [5].
His leg ulcers were treated by application of tretinoin tocoferil (TT) ointment after surgical debridement; good results were obtained [7].

References

Enhancement of activity of 1alpha, 25-dihydroxyvitamin D3 for growth inhibition and differentiation induction of human myelomonocytic leukemia cells by tretinoin tocoferil, an alpha-tocopherol ester of all-trans retinoic acid. Makishima, M., Kanatani, Y., Yamamoto-Yamaguchi, Y., Honma, Y. Blood (1996) [Pubmed]
Effects of tretinoin tocoferil on gene expression of the extracellular matrix components in human dermal fibroblasts in vitro. Mori, Y., Hatamochi, A., Takeda, K., Ueki, H. J. Dermatol. Sci. (1994) [Pubmed]
Topical tocoretinate improved hypertrophic scar, skin sclerosis in systemic sclerosis and morphea. Mizutani, H., Yoshida, T., Nouchi, N., Hamanaka, H., Shimizu, M. J. Dermatol. (1999) [Pubmed]
Tocoretinate inhibited the contraction of collagen gel matrices by human dermal fibroblasts with tenascin-C expression. Yamada, E., Mizutani, H., Yoshida, T., Isoda, K., Shimizu, M. J. Dermatol. Sci. (1999) [Pubmed]
Tretinoin tocoferil as a possible differentiation-inducing agent against myelomonocytic leukemia. Makishima, M., Honma, Y. Leuk. Lymphoma (1997) [Pubmed]
Enhancement by tocoretinate of epidermal growth factor-induced DNA synthesis in human intestinal epithelial cells. Kawamura, N., Miki, K., Kurokawa, K., Kojima, I. Dig. Dis. Sci. (1994) [Pubmed]
Successful treatment for leg ulcers due to hydroxyurea in a patient with chronic myelogenous leukaemia. Kawabata, H., Kamada, T., Takatsuka, Y., Takeuchi, S., Suzuki, S., Makino, T., Utsunomiya, A. Haematologia (Budap) (2002) [Pubmed]

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