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Gene Review

TNC  -  tenascin C

Homo sapiens

Synonyms: 150-225, Cytotactin, DFNA56, GMEM, GP, ...
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Disease relevance of TNC


High impact information on TNC


Chemical compound and disease context of TNC


Biological context of TNC


Anatomical context of TNC


Associations of TNC with chemical compounds

  • EGFR-dependent adhesion was noted when the ligands were tethered to inert beads, simulating the physiologically relevant presentation of tenascin-C as hexabrachion, and suggesting an increase in avidity similar to that seen for integrin ligands upon surface binding [13].
  • Platelet derived growth factor induced tenascin-C transcription is phosphoinositide 3-kinase/Akt-dependent and mediated by Ets family transcription factors [18].
  • Actinomycin D, an RNA synthesis inhibitor, significantly blocked the PDGF-mediated upregulation of TN-C mRNA expression, whereas cycloheximide, a protein synthesis inhibitor, did not [18].
  • The cells failed to adhere to Tn-C but adhered to Fn/Tn-C and were then more efficiently inhibited by the function-blocking integrin mAbs and RGD peptide [19].
  • CS and TN (but not FN) were expressed pericellularly in these cell groups [20].

Physical interactions of TNC

  • For example, an antibody to the beta 1 subfamily of integrins partially inhibited binding of cells to intact CT but did not inhibit cell binding to the third FN type III repeat [14].
  • RPTPbeta-dependent cell adhesion was mediated by binding to the alternatively spliced FNIII repeats A1,2,4 (TnfnA1,2,4) of tenascin C [21].
  • CONCLUSIONS:: Tenascin-C has previously been described in its complex relationship with decorin and fibronectin in normal wound healing [22].
  • Chondroitinase treatment of the proteoglycans did not affect their binding to either native tenascin-C or to any of the recombinant proteins, demonstrating that these interactions are mediated by the proteoglycan core proteins rather than through the glycosaminoglycan chains [23].
  • Bone marrow mononuclear cells can adhere to plastic-immobilized tenascin-C, and in the present study we have used bacterial expression proteins to map the domains of tenascin-C responsible for binding of hematopoietic cells [24].

Co-localisations of TNC


Regulatory relationships of TNC


Other interactions of TNC


Analytical, diagnostic and therapeutic context of TNC

  • Moreover, in situ hybridization revealed specific expression of TN-C in migrating microvascular cells in a cerebral microvascular ring assay [1].
  • When seeded onto FN matrices, the co-cultures were unaffected by the anti-integrin and anti-FN antibodies and were able to organize a TN-C matrix [30].
  • Using polyactylamide gel electophoresis, RT/PCR analysis and microarrays data, we showed the higher level of tenascin-C in the human tumor tissues: brain, intestine and breast [31].
  • RNAs were collected and analyzed with Northern blots for TN-C, Fib-1 and beta(2)-microglobulin [32].
  • MMP-2, CD, and TN-C expressions were evaluated by immunohistochemistry and correlated with clinicopathologic prognostic parameters and survival [33].


  1. Tenascin-C promotes microvascular cell migration and phosphorylation of focal adhesion kinase. Zagzag, D., Shiff, B., Jallo, G.I., Greco, M.A., Blanco, C., Cohen, H., Hukin, J., Allen, J.C., Friedlander, D.R. Cancer Res. (2002) [Pubmed]
  2. Tenascin-C, proliferation and subendothelial fibronectin in progressive pulmonary vascular disease. Jones, P.L., Cowan, K.N., Rabinovitch, M. Am. J. Pathol. (1997) [Pubmed]
  3. Degradation of tenascin-C and activity of matrix metalloproteinase-2 are associated with tumor recurrence in early stage non-small cell lung cancer. Cai, M., Onoda, K., Takao, M., Kyoko, I.Y., Shimpo, H., Yoshida, T., Yada, I. Clin. Cancer Res. (2002) [Pubmed]
  4. The molecular structure of cell adhesion molecules. Chothia, C., Jones, E.Y. Annu. Rev. Biochem. (1997) [Pubmed]
  5. Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease. Hubner, N., Wallace, C.A., Zimdahl, H., Petretto, E., Schulz, H., Maciver, F., Mueller, M., Hummel, O., Monti, J., Zidek, V., Musilova, A., Kren, V., Causton, H., Game, L., Born, G., Schmidt, S., Müller, A., Cook, S.A., Kurtz, T.W., Whittaker, J., Pravenec, M., Aitman, T.J. Nat. Genet. (2005) [Pubmed]
  6. A recessive form of the Ehlers-Danlos syndrome caused by tenascin-X deficiency. Schalkwijk, J., Zweers, M.C., Steijlen, P.M., Dean, W.B., Taylor, G., van Vlijmen, I.M., van Haren, B., Miller, W.L., Bristow, J. N. Engl. J. Med. (2001) [Pubmed]
  7. Gray-scale ultrasonography and thin-needle cholangiography. Evaluation in the jaundiced patient. Goldstein, L.I., Sample, W.F., Kadell, B.M., Weiner, M. JAMA (1977) [Pubmed]
  8. The de-adhesive activity of matricellular proteins: is intermediate cell adhesion an adaptive state? Murphy-Ullrich, J.E. J. Clin. Invest. (2001) [Pubmed]
  9. Tenascin-C expression by angiogenic vessels in human astrocytomas and by human brain endothelial cells in vitro. Zagzag, D., Friedlander, D.R., Dosik, J., Chikramane, S., Chan, W., Greco, M.A., Allen, J.C., Dorovini-Zis, K., Grumet, M. Cancer Res. (1996) [Pubmed]
  10. Binding of hexabrachions to heparin and DNA. Marton, L.S., Gulcher, J.R., Stefansson, K. J. Biol. Chem. (1989) [Pubmed]
  11. Immunochemical and biochemical characterization of a glioma-associated extracellular matrix glycoprotein. Bourdon, M.A., Matthews, T.J., Pizzo, S.V., Bigner, D.D. J. Cell. Biochem. (1985) [Pubmed]
  12. Immunohistochemical assessment of fibronectin and tenascin and their integrin receptors alpha5beta1 and alpha9beta1 in gastric and colorectal cancers with lymph node and liver metastases. Gulubova, M., Vlaykova, T. Acta Histochem. (2006) [Pubmed]
  13. Epidermal growth factor (EGF)-like repeats of human tenascin-C as ligands for EGF receptor. Swindle, C.S., Tran, K.T., Johnson, T.D., Banerjee, P., Mayes, A.M., Griffith, L., Wells, A. J. Cell Biol. (2001) [Pubmed]
  14. Multiple integrins mediate cell attachment to cytotactin/tenascin. Prieto, A.L., Edelman, G.M., Crossin, K.L. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  15. The complete cDNA sequence of human hexabrachion (Tenascin). A multidomain protein containing unique epidermal growth factor repeats. Nies, D.E., Hemesath, T.J., Kim, J.H., Gulcher, J.R., Stefansson, K. J. Biol. Chem. (1991) [Pubmed]
  16. Tenascin-C upregulation by transforming growth factor-beta in human dermal fibroblasts involves Smad3, Sp1, and Ets1. Jinnin, M., Ihn, H., Asano, Y., Yamane, K., Trojanowska, M., Tamaki, K. Oncogene (2004) [Pubmed]
  17. Human tenascin: primary structure, pre-mRNA splicing patterns and localization of the epitopes recognized by two monoclonal antibodies. Siri, A., Carnemolla, B., Saginati, M., Leprini, A., Casari, G., Baralle, F., Zardi, L. Nucleic Acids Res. (1991) [Pubmed]
  18. Platelet derived growth factor induced tenascin-C transcription is phosphoinositide 3-kinase/Akt-dependent and mediated by Ets family transcription factors. Jinnin, M., Ihn, H., Asano, Y., Yamane, K., Trojanowska, M., Tamaki, K. J. Cell. Physiol. (2006) [Pubmed]
  19. Production of fibronectin and tenascin isoforms and their role in the adhesion of human immortalized corneal epithelial cells. Filenius, S., Tervo, T., Virtanen, I. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  20. Cellular and molecular tunnels surrounding the forebrain commissures of human fetuses. Lent, R., Uziel, D., Baudrimont, M., Fallet, C. J. Comp. Neurol. (2005) [Pubmed]
  21. Glial tumor cell adhesion is mediated by binding of the FNIII domain of receptor protein tyrosine phosphatase beta (RPTPbeta) to tenascin C. Adamsky, K., Schilling, J., Garwood, J., Faissner, A., Peles, E. Oncogene (2001) [Pubmed]
  22. Intraschisis cavity fluid composition in congenital x-linked retinoschisis. Joshi, M.M., Drenser, K., Hartzer, M., Dailey, W., Capone, A., Trese, M.T. Retina (Philadelphia, Pa.) (2006) [Pubmed]
  23. The fibrinogen-like globe of tenascin-C mediates its interactions with neurocan and phosphacan/protein-tyrosine phosphatase-zeta/beta. Milev, P., Fischer, D., Häring, M., Schulthess, T., Margolis, R.K., Chiquet-Ehrismann, R., Margolis, R.U. J. Biol. Chem. (1997) [Pubmed]
  24. Mitogenic and adhesive effects of tenascin-C on human hematopoietic cells are mediated by various functional domains. Seiffert, M., Beck, S.C., Schermutzki, F., Müller, C.A., Erickson, H.P., Klein, G. Matrix Biol. (1998) [Pubmed]
  25. Tenascin-C splice variant adhesive/anti-adhesive effects on chondrosarcoma cell attachment to fibronectin. Ghert, M.A., Qi, W.N., Erickson, H.P., Block, J.A., Scully, S.P. Cell Struct. Funct. (2001) [Pubmed]
  26. Over-expression of tenascin-C in malignant pleural mesothelioma. Kaarteenaho-Wiik, R., Soini, Y., Pöllänen, R., Pääkkö, P., Kinnula, V.L. Histopathology (2003) [Pubmed]
  27. Effects of tenascin-C on normal and diabetic retinal endothelial cells in culture. Castellon, R., Caballero, S., Hamdi, H.K., Atilano, S.R., Aoki, A.M., Tarnuzzer, R.W., Kenney, M.C., Grant, M.B., Ljubimov, A.V. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  28. Tenascin suppresses CD3-mediated T cell activation. Hibino, S., Kato, K., Kudoh, S., Yagita, H., Okumura, K. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  29. beta-Catenin regulates the expression of tenascin-C in human colorectal tumors. Beiter, K., Hiendlmeyer, E., Brabletz, T., Hlubek, F., Haynl, A., Knoll, C., Kirchner, T., Jung, A. Oncogene (2005) [Pubmed]
  30. Tenascin-C matrix assembly in oral squamous cell carcinoma. Ramos, D.M., Chen, B., Regezi, J., Zardi, L., Pytela, R. Int. J. Cancer (1998) [Pubmed]
  31. Analysis of structure and function of tenascin-C. Pas, J., Wyszko, E., Rolle, K., Rychlewski, L., Nowak, S., Zukiel, R., Barciszewski, J. Int. J. Biochem. Cell Biol. (2006) [Pubmed]
  32. Insulin-like growth factor-I (IGF-I) and transforming growth factor-beta (TGF-beta) modulate tenascin-C and fibrillin-1 in bullous keratopathy stromal cells in vitro. Kenney, M.C., Zorapapel, N., Atilano, S., Chwa, M., Ljubimov, A., Brown, D. Exp. Eye Res. (2003) [Pubmed]
  33. Prognostic significance of matrix metalloproteinase-2, cathepsin D, and tenascin-C expression in colorectal carcinoma. Sis, B., Sağol, O., Küpelioğlu, A., Sokmen, S., Terzi, C., Fuzun, M., Ozer, E., Bishop, P. Pathol. Res. Pract. (2004) [Pubmed]
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