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Chemical Compound Review

URANYL NITRATE     dioxouranium; nitric acid

Synonyms: Yellow salt, HSDB 1018, UN2981, LS-158714, LS-158715, ...
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Disease relevance of URANYL NITRATE


High impact information on URANYL NITRATE


Chemical compound and disease context of URANYL NITRATE


Biological context of URANYL NITRATE


Anatomical context of URANYL NITRATE

  • Adult female Lewis rats were given injections of either 2 or 5 mg/kg of uranyl nitrate (saline for controls) or had both ureters ligated (sham operation for controls) to provide different experimental models of renal dysfunction [19].
  • H+-coupled Gly-Sar uptake was reduced in renal brush-border vesicles from uranyl nitrate-treated rats compared to control rats [20].
  • These results suggest that uranyl nitrate-induced ARF caused alterations in the transport properties of renal brush border membranes and that these transport dysfunctions were not due to the direct effect of uranyl nitrate, but could be secondarily induced after the impairment of the integrity for tubular cells [21].
  • Ethanol concentrations at onset of loss of righting reflex in cerebrospinal fluid, serum and brain of rats with severe renal dysfunction (5 mg/kg of uranyl nitrate-treated and ureterligated groups) were slightly but statistically significantly lower than in normal controls [19].
  • To investigate the toxic effects of environmental DU exposure on the immune system, we examined the influences of DU (in the form of uranyl nitrate) on viability and immune function as well as cytokine gene expression in murine peritoneal macrophages and splenic CD4+ T cells [22].

Associations of URANYL NITRATE with other chemical compounds


Gene context of URANYL NITRATE

  • It has been reported from our laboratories that expression of CYP2E1 significantly increased and decreased in rats with acute renal failure induced by uranyl nitrate (U-ARF) treated with recombinant human growth hormone (rGH) for one day (U-ARF1) compared with those in control rats and rats with U-ARF, respectively [28].
  • A protective effect of similar magnitude was observed whether angiotensin-converting enzyme inhibitor treatment preceded, or shortly followed, the administration of uranyl nitrate [2].
  • Relationship between severity of renal damage and erythropoietin production in uranyl nitrate-induced acute renal failure [29].
  • Electrophysiological studies on the effects of uranyl nitrate on the diaphragm in the mouse have revealed that the frequency of miniature end-plate potentials (MEPP) but not the amplitude was increased; the amplitude and quantal content of end-plate potential (EPPs) were also markedly increased by uranyl nitrate [18].
  • Effect of the TBP and water on the complexation of uranyl nitrate and the dissolution of nitric acid into supercritical CO2. A Theoretical Study [24].

Analytical, diagnostic and therapeutic context of URANYL NITRATE


  1. The mechanism of acute renal failure after uranyl nitrate. Blantz, R.C. J. Clin. Invest. (1975) [Pubmed]
  2. Attenuation of nephrotoxic acute renal failure in the dog with angiotensin-converting enzyme inhibitor (SQ-20,881). Lindner, A., Cutler, R.E., Bell, A.J. Circ. Res. (1982) [Pubmed]
  3. Efficacies of imipenem, meropenem, cefepime, and ceftazidime in rats with experimental pneumonia due to a carbapenem-hydrolyzing beta-lactamase-producing strain of Enterobacter cloacae. Mimoz, O., Leotard, S., Jacolot, A., Padoin, C., Louchahi, K., Petitjean, O., Nordmann, P. Antimicrob. Agents Chemother. (2000) [Pubmed]
  4. The influence of age on acute renal toxicity of uranyl nitrate in the dog. Pelayo, J.C., Andrews, P.M., Coffey, A.K., Calcagno, P.L., Eisner, G.M., Jose, P.A. Pediatr. Res. (1983) [Pubmed]
  5. Glomerular endothelial cells in uranyl nitrate-induced acute renal failure in rats. Avasthi, P.S., Evan, A.P., Hay, D. J. Clin. Invest. (1980) [Pubmed]
  6. Pharmacokinetic-pharmacodynamic modeling of electroencephalogram effect of imipenem in rats with acute renal failure. Dupuis, A., Limosin, A., Paquereau, J., Mimoz, O., Couet, W., Bouquet, S. Antimicrob. Agents Chemother. (2001) [Pubmed]
  7. Aminoglycoside-arginine conjugates that bind TAR RNA: synthesis, characterization, and antiviral activity. Litovchick, A., Evdokimov, A.G., Lapidot, A. Biochemistry (2000) [Pubmed]
  8. In vivo activities of amoxicillin and amoxicillin-clavulanate against Streptococcus pneumoniae: application to breakpoint determinations. Andes, D., Craig, W.A. Antimicrob. Agents Chemother. (1998) [Pubmed]
  9. Intrarenal renin, angiotensin II, and plasma renin in rats with uranyl nitrate-induced and glycerol-induced acute renal failure. Mendelsohn, F.A., Smith, E.A. Kidney Int. (1980) [Pubmed]
  10. Synergism of dopamine plus furosemide in preventing acute renal failure in the dog. Lindner, A., Cutler, R.E., Goodman, G. Kidney Int. (1979) [Pubmed]
  11. Effect of dithiothreitol on mercuric chloride- and uranyl nitrate-induced acute renal failure in the rat. Kleinman, J.G., McNeil, J.S., Schwartz, J.H., Hamburger, R.J., Flamenbaum, W. Kidney Int. (1977) [Pubmed]
  12. Pharmacodynamic assessment of cefprozil against Streptococcus pneumoniae: implications for breakpoint determinations. Nicolau, D.P., Onyeji, C.O., Zhong, M., Tessier, P.R., Banevicius, M.A., Nightingale, C.H. Antimicrob. Agents Chemother. (2000) [Pubmed]
  13. Reduced extraction of I-propranolol by perfused rat liver in the presence of uremic blood. Terao, N., Shen, D.D. J. Pharmacol. Exp. Ther. (1985) [Pubmed]
  14. Renal handling of drugs in renal failure. I: Differential effects of uranyl nitrate- and glycerol-induced acute renal failure on renal excretion of TEAB and PAH in rats. Lin, J.H., Lin, T.H. J. Pharmacol. Exp. Ther. (1988) [Pubmed]
  15. Pharmacokinetics of a new carbapenem, DA-1131, after intravenous administration to rats with uranyl nitrate-induced acute renal failure. Kim, S.H., Shim, H.J., Kim, W.B., Lee, M.G. Antimicrob. Agents Chemother. (1998) [Pubmed]
  16. Pathophysiology of a nephrotoxic model of acute renal failure. Stein, J.H., Gottschall, J., Osgood, R.W., Ferris, T.F. Kidney Int. (1975) [Pubmed]
  17. Functional basis for the glomerular alterations in uranyl nitrate acute renal failure. Blantz, R.C., Pelayo, J.C., Gushwa, L.C., Myers, R.R., Evan, A.P. Kidney Int. (1985) [Pubmed]
  18. Presynaptic action of uranyl nitrate on the phrenic nerve-diaphragm preparation of the mouse. Lin, R.H., Fu, W.M., Lin-Shiau, S.Y. Neuropharmacology (1988) [Pubmed]
  19. Kinetics of drug action in disease states. VII. Effect of experimental renal dysfunction on the pharmacodynamics of ethanol in rats. Hisaoka, M., Danhof, M., Levy, G. J. Pharmacol. Exp. Ther. (1985) [Pubmed]
  20. Peptidases and peptide transport in renal brush-border membrane vesicles from rats with acute renal failure. Miyamoto, Y., Ganapathy, V., Leibach, F.H. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
  21. Transport of p-aminohippurate, tetraethylammonium and D-glucose in renal brush border membranes from rats with acute renal failure. Hori, R., Takano, M., Okano, T., Inui, K. J. Pharmacol. Exp. Ther. (1985) [Pubmed]
  22. In vitro immune toxicity of depleted uranium: effects on murine macrophages, CD4+ T cells, and gene expression profiles. Wan, B., Fleming, J.T., Schultz, T.W., Sayler, G.S. Environ. Health Perspect. (2006) [Pubmed]
  23. Uranyl nitrate: 91-day toxicity studies in the New Zealand white rabbit. Gilman, A.P., Villeneuve, D.C., Secours, V.E., Yagminas, A.P., Tracy, B.L., Quinn, J.M., Valli, V.E., Moss, M.A. Toxicol. Sci. (1998) [Pubmed]
  24. Effect of the TBP and water on the complexation of uranyl nitrate and the dissolution of nitric acid into supercritical CO2. A Theoretical Study. Schurhammer, R., Wipff, G. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory. (2005) [Pubmed]
  25. Effect of recognized and unrecognized salt on the self-assembly of new thermosensitive metal-chelating surfactants. Coulombeau, H., Testard, F., Zemb, T., Larpent, C. Langmuir : the ACS journal of surfaces and colloids. (2004) [Pubmed]
  26. Ethane 1-hydroxy-1, 1-diphosphonate (EHDP) counteracts the inhibitory effect of uranyl nitrate on bone formation. Ubios, A.M., Guglielmotti, M.B., Cabrini, R.L. Arch. Environ. Health (1990) [Pubmed]
  27. Theophylline neurotoxicity is unaffected by glycerol-induced renal failure. Ramzan, I. Pharmacol. Biochem. Behav. (1990) [Pubmed]
  28. Effects of recombinant human growth hormone on the pharmacokinetics of intravenous chlorzoxazone in rats with acute renal failure induced by uranyl nitrate. Chung, W., Kim, E.J., Lee, I., Kim, S.G., Lee, M.G., Kim, S.H. Life Sci. (2003) [Pubmed]
  29. Relationship between severity of renal damage and erythropoietin production in uranyl nitrate-induced acute renal failure. Giglio, M.J., Bozzini, C.E., Barcat, J.A., Arrizurieta, E. Exp. Hematol. (1986) [Pubmed]
  30. Calcium-binding proteins annexin A2 and S100A6 are sensors of tubular injury and recovery in acute renal failure. Cheng, C.W., Rifai, A., Ka, S.M., Shui, H.A., Lin, Y.F., Lee, W.H., Chen, A. Kidney Int. (2005) [Pubmed]
  31. Kinetics of drug action in disease states. XVIII. Effect of experimental renal failure on the pharmacodynamics of theophylline-induced seizures in rats. Ramzan, I.M., Levy, G. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  32. Reduced hepatic uptake of propranolol in rats with acute renal failure. Hori, R., Okumura, K., Yasuhara, M., Katayama, H. Biochem. Pharmacol. (1985) [Pubmed]
  33. Morphologic changes in uranyl nitrate-induced acute renal failure in saline- and water-drinking rats. Haley, D.P. Lab. Invest. (1982) [Pubmed]
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