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Chemical Compound Review

Cefazedona     (6R,7S)-7-[2-(3,5-dichloro-4- oxo-pyridin-1...

Synonyms: Cefazedone, Refosporen, Refosporin, Cefazedonum, Refosporene, ...
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Disease relevance of AIDS156235


High impact information on AIDS156235

  • In vitro activity of cefazedone, a new cephalosporin antibiotic [5].
  • Interim and postmortem cytologic and histologic observations of bone marrow included hypoplastic and toxic changes, primarily in cytopenic dogs receiving high doses of cefonicid, and regenerative changes in hematopoietic tissue of affected cefazedone-treated animals [6].
  • Fourteen healthy dogs were given 540 to 840 mg/kg of cefazedone (Refosporen) intravenously for up to 4 months or until peripheral blood cell count were depressed [7].
  • We conclude that in dogs prolonged administration of high doses of cefazedone induced a persistent deficit of CFU-E and CFU-GM progenitor cells [8].
  • Distinct bactericidal activity of (6R,7R)-7-(2-[3,5-dichloro-4-oxo-1(4H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl)-thio]methyl)-8-oxo-5-thia-1-aza-bicyclo[4,2,0]oct-2-ene-2-carboxylic acid (cefazedone, Refosporen) could be demonstrated in 2 Staphylococcus aureus and 3 Escherichia coli strains [9].

Chemical compound and disease context of AIDS156235

  • In 5 out of 14 strains (Staphylococci, Streptococci, E. coli, Klebsiella) cefazedone was markedly superior to cefazolin, whereas both compounds were of similar activity against the remaining 9 isolates [10].

Biological context of AIDS156235


Gene context of AIDS156235


Analytical, diagnostic and therapeutic context of AIDS156235


  1. The hematologic effects of cefonicid and cefazedone in the dog: a potential model of cephalosporin hematotoxicity in man. Bloom, J.C., Lewis, H.B., Sellers, T.S., Deldar, A. Toxicol. Appl. Pharmacol. (1987) [Pubmed]
  2. Cephalosporin-induced immune cytopenia in the dog: demonstration of erythrocyte-, neutrophil-, and platelet-associated IgG following treatment with cefazedone. Bloom, J.C., Thiem, P.A., Sellers, T.S., Deldar, A., Lewis, H.B. Am. J. Hematol. (1988) [Pubmed]
  3. Failure of cephalosporins to cure experimental listeriosis. Kawaler, B., Hof, H. J. Infect. (1984) [Pubmed]
  4. Investigations on antibacterial activity of cefazedone against Neisseria gonorrhoeae. Gründer, K., Petzoldt, D. Arzneimittel-Forschung. (1979) [Pubmed]
  5. In vitro activity of cefazedone, a new cephalosporin antibiotic. Russell, A.D., Rogers, D.T. J. Antimicrob. Chemother. (1980) [Pubmed]
  6. The hematopathology of cefonicid- and cefazedone-induced blood dyscrasias in the dog. Bloom, J.C., Lewis, H.B., Sellers, T.S., Deldar, A., Morgan, D.G. Toxicol. Appl. Pharmacol. (1987) [Pubmed]
  7. Cephalosporin-induced changes in the ultrastructure of canine bone marrow. Deldar, A., Lewis, H., Bloom, J., Weiss, L. Vet. Pathol. (1988) [Pubmed]
  8. Cephalosporin-induced alterations in erythroid (CFU-E) and granulocyte-macrophage (CFU-GM) colony-forming capacity in canine bone marrow. Deldar, A., Lewis, H., Bloom, J., Weiss, L. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1988) [Pubmed]
  9. Bactericidal activity of cefazedone. Dingeldein, E. Arzneimittel-Forschung. (1979) [Pubmed]
  10. Comparison of cefazedone with cefazolin and cephalothin in treatment of experimental infections in mice. Bergmann, R., Wahlig, H., Mitsuhashi, S. Arzneimittel-Forschung. (1979) [Pubmed]
  11. Pharmacokinetic investigations of cefazedone in gynaecology and obstetrics. von Kobyletzki, D., Sas, M., Dingeldein, E., Wahlig, H., Wiemann, H. Arzneimittel-Forschung. (1979) [Pubmed]
  12. Pharmacokinetics and metabolism of cefazedone in Wistar rat, beagle dog and rhesus monkey. Sailer, H., Diekmann, H.W., Faro, H.P., Garbe, A. Arzneimittel-Forschung. (1979) [Pubmed]
  13. MIC determination, disc sensitivity testing, and analysis of regression in cefazedone and cefazolin. Dingeldein, E., Wahlig, H. Arzneimittel-Forschung. (1979) [Pubmed]
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