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Chemical Compound Review

AC1LCV41     (7S)-3-[(5-methyl-1,3,4- thiadiazol-2...

Synonyms: DB01327
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Disease relevance of cefazolin


Psychiatry related information on cefazolin


High impact information on cefazolin


Chemical compound and disease context of cefazolin


Biological context of cefazolin


Anatomical context of cefazolin


Associations of cefazolin with other chemical compounds


Gene context of cefazolin


Analytical, diagnostic and therapeutic context of cefazolin

  • In abdominal hysterectomy, cefazolin decreased in-hospital morbidity from 43% to 25% (preventive fraction, 42%), resulting in an average net savings of +102 per patient [33].
  • In patients undergoing vaginal hysterectomy, prophylactic cefazolin reduced in-hospital infectious morbidity from 52% to 23% (preventive fraction, 56%), resulting in an average net benefit of +492 per patient [33].
  • The effect of five days of antibiotic prophylaxis with cefazolin injections (beginning just before surgery) on postoperative infections (beginning just before surgery) on postoperative infectious complications was evaluated in a double-blind, randomised, placebo-controlled trial in nine centres on 2137 patients undergoing hip replacement [34].
  • Long-term results of prophylactic cefazolin versus placebo in total hip replacement [35].
  • Patients received either intravenous saline as a placebo or intravenous cefazolin (1 g) 30 minutes before gastrostomy [36].


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  2. Unsuccessful treatment of staphylococcal endocarditis with cefazolin. Bryant, R.E., Alford, R.H. JAMA (1977) [Pubmed]
  3. Cefazolin vs penicillin. Treatment of uncomplicated pneumococcal pneumonia. Jenkinson, S.G., George, R.B., Light, R.W., Girard, W.M. JAMA (1979) [Pubmed]
  4. Randomised clinical trial of perioperative cefazolin in preventing infection after hysterectomy. Polk, B.F., Tager, I.B., Shapiro, M., Goren-White, B., Goldstein, P., Schoenbaum, S.C. Lancet (1980) [Pubmed]
  5. Comparison of vancomycin versus cefazolin as initial therapy for peritonitis in peritoneal dialysis patients. Khairullah, Q., Provenzano, R., Tayeb, J., Ahmad, A., Balakrishnan, R., Morrison, L. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. (2002) [Pubmed]
  6. Acute confusional state with postoperative intravenous cefazolin. Herd, A.M., Ross, C.A., Bhattacharya, S.K. BMJ (1989) [Pubmed]
  7. Behavioral and electrocortical effects after intrastriatal cefazolin in rats are antagonized by drugs enhancing GABA-ergic transmission. Nistico, G., De Sarro, G.B., Rotiroti, D., Naccari, F., Calo, M., Silvestri, R., Pisanti, N. Res. Commun. Chem. Pathol. Pharmacol. (1980) [Pubmed]
  8. Failure of cephalosporins to prevent Staphylococcus aureus surgical wound infections. Kernodle, D.S., Classen, D.C., Burke, J.P., Kaiser, A.B. JAMA (1990) [Pubmed]
  9. Cefazolin. Quintiliani, R., Nightingale, C.H. Ann. Intern. Med. (1978) [Pubmed]
  10. Long half-life for cefazolin in anuria. Moore, T.D., Seth, S.K. Ann. Intern. Med. (1978) [Pubmed]
  11. Pharmacokinetics of intermittent intravenous cefazolin and tobramycin in patients treated with automated peritoneal dialysis. Manley, H.J., Bailie, G.R., Frye, R., Hess, L.D., McGoldrick, M.D. J. Am. Soc. Nephrol. (2000) [Pubmed]
  12. Outcomes of osteomyelitis among patients treated with outpatient parenteral antimicrobial therapy. Tice, A.D., Hoaglund, P.A., Shoultz, D.A. Am. J. Med. (2003) [Pubmed]
  13. Overview of bacterial infections of the skin and soft tissue and clinical experience with ticarcillin plus clavulanate potassium in their treatment. Pankey, G.A., Katner, H.P., Valainis, G.T., Clarkson, M.J., Cortez, L.M., Dalovisio, J.R. Am. J. Med. (1985) [Pubmed]
  14. Cefazolin and cephalexin kinetics in continuous ambulatory peritoneal dialysis. Bunke, C.M., Aronoff, G.R., Brier, M.E., Sloan, R.S., Luft, F.C. Clin. Pharmacol. Ther. (1983) [Pubmed]
  15. Daptomycin (LY146032) for prevention and treatment of experimental aortic valve endocarditis in rabbits. Kennedy, S., Chambers, H.F. Antimicrob. Agents Chemother. (1989) [Pubmed]
  16. Antibiotic prophylaxis in vascular surgery. Kaiser, A.B., Clayson, K.R., Mulherin, J.L., Roach, A.C., Allen, T.R., Edwards, W.H., Dale, W.A. Ann. Surg. (1978) [Pubmed]
  17. Intraoperative redosing of cefazolin and risk for surgical site infection in cardiac surgery. Zanetti, G., Giardina, R., Platt, R. Emerging Infect. Dis. (2001) [Pubmed]
  18. Effect of cardiopulmonary bypass on cefazolin disposition. Miller, K.W., McCoy, H.G., Chan, K.K., Fischer, R.P., Lindsay, W.G., Seifert, R.D., Zaske, D.E. Clin. Pharmacol. Ther. (1980) [Pubmed]
  19. Penetration of antibiotics into the surgical wound in a canine model. Rosin, E., Ebert, S., Uphoff, T.S., Evans, M.H., Schultz-Darken, N.J. Antimicrob. Agents Chemother. (1989) [Pubmed]
  20. Effects of general and local anesthesia on the pharmacokinetics of cefazolin in patients undergoing orthopedic surgery. Welch, W.D., Jantzen, J.P., Johnson, K., Bawdon, R.E. Antimicrob. Agents Chemother. (1985) [Pubmed]
  21. Cephalosporin-induced recurrent aseptic meningitis. Creel, G.B., Hurtt, M. Ann. Neurol. (1995) [Pubmed]
  22. Ceftriaxone for once-a-day therapy of urinary tract infections. Childs, S.J., Wells, W.G., Mirelman, S. Am. J. Med. (1984) [Pubmed]
  23. Penicillin-binding proteins and role of amdinocillin in causing bacterial cell death. Neu, H.C. Am. J. Med. (1983) [Pubmed]
  24. Clinical consequences and cost of limiting use of vancomycin for perioperative prophylaxis: example of coronary artery bypass surgery. Zanetti, G., Goldie, S.J., Platt, R. Emerging Infect. Dis. (2001) [Pubmed]
  25. Interpretation of susceptibility testing of ceftriaxone. Squires, E., Cleeland, R., Christenson, J., Boehni, E. Am. J. Med. (1984) [Pubmed]
  26. Antibiotic penetration into normal and inflamed tissues as reflected by peripheral lymph. Roberts, T.L., Futrell, J.W., Sande, M.A. Ann. Surg. (1979) [Pubmed]
  27. Importance of beta-lactamase inactivation in treatment of experimental endocarditis caused by Staphylococcus aureus. Goldman, P.L., Petersdorf, R.G. J. Infect. Dis. (1980) [Pubmed]
  28. Lack of association of Staphylococcus aureus type A beta-lactamase with cefazolin combined with antimicrobial spacer placement prosthetic joint infection treatment failure. Shuford, J.A., Piper, K.E., Hein, M., Trampuz, A., Steckelberg, J.M., Patel, R. Diagn. Microbiol. Infect. Dis. (2006) [Pubmed]
  29. Simulation of human serum pharmacokinetics of cefazolin, piperacillin, and BRL 42715 in rats and efficacy against experimental intraperitoneal infections. Woodnutt, G., Berry, V., Mizen, L. Antimicrob. Agents Chemother. (1992) [Pubmed]
  30. Alternative activity of beta-lactam antibiotics against methicillin- and cephem-resistant Staphylococcus aureus in the presence of respiratory tract mucus. Igarashi, K., Matsuyama, T. J. Infect. Dis. (1990) [Pubmed]
  31. Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases. Sakurai, Y., Motohashi, H., Ueo, H., Masuda, S., Saito, H., Okuda, M., Mori, N., Matsuura, M., Doi, T., Fukatsu, A., Ogawa, O., Inui, K. Pharm. Res. (2004) [Pubmed]
  32. Cefazolin administration and 2-methyl-1,3,4-thiadiazole-5-thiol in human tissue: possible relationship to hypoprothrombinemia. Wood, T.C., Johnson, K.L., Naylor, S., Weinshilboum, R.M. Drug Metab. Dispos. (2002) [Pubmed]
  33. Benefit-cost analysis of antimicrobial prophylaxis in abdominal and vaginal hysterectomy. Shapiro, M., Schoenbaum, S.C., Tager, I.B., Muñoz, A., Polk, B.F. JAMA (1983) [Pubmed]
  34. Prophylactic cefazolin versus placebo in total hip replacement. Report of a multicentre double-blind randomised trial. Hill, C., Flamant, R., Mazas, F., Evrard, J. Lancet (1981) [Pubmed]
  35. Long-term results of prophylactic cefazolin versus placebo in total hip replacement. Doyon, F., Evrard, J., Mazas, F., Hill, C. Lancet (1987) [Pubmed]
  36. Antibiotic prophylaxis for percutaneous endoscopic gastrostomy. A prospective, randomized, double-blind clinical trial. Jain, N.K., Larson, D.E., Schroeder, K.W., Burton, D.D., Cannon, K.P., Thompson, R.L., DiMagno, E.P. Ann. Intern. Med. (1987) [Pubmed]
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