Disease relevance of NSC6183

• Nephrotoxicity occurs as one toxicity following intraperitoneal (i.p.) administration of chloroaniline hydrochlorides to rats [1].
• Pseudomonas acidovorans: a bacterium capable of mineralizing 2-chloroaniline [2].
• Mutagenicity of chloroaniline/lignin metabolites in the Salmonella/microsome assay [3].

High impact information on NSC6183

• 2-Chloronitrobenezene was converted by isolated hepatocytes to 2-chloroaniline, 2-chloroaniline-N-glucuronide, and S-(2-nitrophenyl)glutathione in approximately equal quantities (13-19% of the added substrate in 90 min) [4].
• Assessment of chloroaniline toxicity by the submitochondrial particle assay [5].
• Biotransformation of 2-chloroaniline in the Fischer 344 rat: identification of urinary metabolites [6].
• The purpose of this study was to evaluate the in vivo and in vitro nephrotoxic potential of 2-amino-5-chlorophenol and 4-amino-3-chlorophenol, metabolites of 4-chloroaniline and 2-chloroaniline [7].
• 1. Guppies (Poecilia reticulata) were exposed for 96 h to 4-chloroaniline (4CA), 3-chloroaniline (3CA) and 2-chloroaniline (2CA) in a static exposure system [8].

Biological context of NSC6183

• Percutaneous absorption of 4,4'-[14C]methylenebis [2-chloroaniline] (MBOCA) was measured during dry contact exposure of MBOCA with organ cultures of neonatal foreskin [9].
• Biological monitoring of workers exposed to 4,4'-methylenebis (2-chloroaniline) (MBOCA) [10].
• Urine samples from workers exposed to 4,4'-methylenebis (2-chloroaniline) (MbOCA) contain a labile metabolite(s) that, on hydrolysis, yields the parent compound at concentrations two to three times those of free MbOCA [11].

Associations of NSC6183 with other chemical compounds

• A biological monitoring programme has been developed for assessing occupational exposure to 4,4'-methylenebis (2-chloroaniline) (MBOCA) in a factory which manufactures polyurethane elastomers [10].
• Analysis of 3,3'-dichloro-4,4'-diamino-diphenylmethane (MOCA) and 2-chloroaniline (OCA) in air [12].

Analytical, diagnostic and therapeutic context of NSC6183

• After dilution, aniline and 2-chloroaniline in the sample were diffused through a cellular dialysis membrane into the perfusion stream under controlled conditions [13].
• HPLC analysis revealed that o-CPHA was metabolized to o-chloroaniline (o-CA) (95-51-2) and that the metabolic reduction was inhibited by NOH [14].
• Determination of aniline and 2-chloroaniline in polymer industrial wastewater was examined using high-performance liquid chromatography with on-line microdialysis [13].
• The determination of 4,4'-methylenebis (2-chloroaniline) in urine by electron capture gas chromatography [15].
• Immobilization of a model liquid organic pollutant, i.e. the 2-chloroaniline (2-CA), into a cement matrix using organoclays as pre-sorbent agents was investigated [16].

References