Disease relevance of m-Chlorophenylamine

• Bioaugmentation of activated sludge by an indigenous 3-chloroaniline-degrading Comamonas testosteroni strain, I2gfp [1].
• Genetic diversity among 3-chloroaniline- and aniline-degrading strains of the Comamonadaceae [2].
• Comparative gavage subchronic toxicity studies of o-chloroaniline and m-chloroaniline in F344 rats and B6C3F1 mice [3].
• Characterization of isofunctional ring-cleaving enzymes in aniline and 3-chloroaniline degradation by Pseudomonas acidovorans CA28 [4].

High impact information on m-Chlorophenylamine

• Each of the aniline derivatives were oxidized by the mutants at rates that exceeded that of the wild-type enzyme, and the rate constant for m-chloroaniline was 400-fold faster for W51F than for wild-type CCP [5].
• We examined the diversity of the plasmids and of the gene tdnQ, involved in the oxidative deamination of aniline, in five bacterial strains that are able to metabolize both aniline and 3-chloroaniline (3-CA) [2].
• Artificial selection of microbial ecosystems for 3-chloroaniline biodegradation [6].
• The major metabolite formed from 3-chloronitrobenzene by isolated hepatocytes was 3-chloroaniline (31% of the added substrate in 90 min) [7].
• AIMS: The applicability of plasmid pNB2 for bioaugmentation of bacteria in model wastewater treatment reactors receiving 3-chloroaniline (3-CA) was investigated [8].

Chemical compound and disease context of m-Chlorophenylamine

• During degradation of aniline and 3-chloroaniline, respectively, by Pseudomonas acidovorans CA28, selective induction of two catechol 1,2-dioxygenases (C12O) was observed [4].

Biological context of m-Chlorophenylamine

• AIMS: The involvement of the aniline-degradative plasmid pNB2 in degradation of 3-chloroaniline (3-CA) was investigated [9].
• Acetylation of 3-chloroaniline, which represents a minor pathway of CIPC metabolism, was already markedly suppressed (43%) with the lowest Cd concentration (27 microM) [10].
• Aniline and 3-chloroaniline degrading bacteria: genetics and possible applications [11].

Anatomical context of m-Chlorophenylamine

• Prolonged adaptation of Ca-alginate immobilized cells of Pseudomonas acidovorans CA28 to a mixture of 3-chloroaniline (3-CA)1) and 2-CA and subsequently to 2-CA as sole substrate led to the isolation of another strain, termed CA50 with the additional capability of utilizing 2-CA as sole source of carbon, nitrogen, and energy [12].

Associations of m-Chlorophenylamine with other chemical compounds

• The utilization of 2-chloroaniline was better than 3-chloroaniline, by Fusarium sp. and Rhizopus sp. Cladosporium sp. was the best isolate which could use aniline blue as the only source of nitrogen [13].
• Rhizopus sp. and Fusarium sp. utilized only 2-chloroaniline and 3-chloroaniline as nitrogen source in the presence of glucose, with production of catechol, ammonium and chloride [13].

Gene context of m-Chlorophenylamine

• 3-Chloroaniline also was the only aniline compound to increase plasma ALT/GPT activity at 48 h [14].

Analytical, diagnostic and therapeutic context of m-Chlorophenylamine

• Bioaugmenting bioreactors for the continuous removal of 3-chloroaniline by a slow release approach [15].

References