The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Gstm1  -  glutathione S-transferase, mu 1

Mus musculus

Synonyms: GST 1-1, GST class-mu 1, Glutathione S-transferase GT8.7, Glutathione S-transferase Mu 1, Gstb-1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Gstm1

  • These two murine cDNAs were subcloned into bacterial expression vectors, and enzymatically active GSTs encoded by pmGT10 (mGTmu1) or pmGT2 (mGTmu2) were purified from transformed Escherichia coli lysates [1].
  • Immunodetection with a monoclonal antibody of glutathione S-transferase mu in patients with and without carcinomas [2].

Psychiatry related information on Gstm1


High impact information on Gstm1

  • We have isolated from a murine cell line (L929) two mu class GST cDNAs, pmGT10 (1.4 kilobases (kb] and pmGT2 (1.1 kb) [1].
  • Analysis of the deduced amino acid sequences revealed 93% homology between pmGT10 and the rat Yb1 (subunit 3) gene and 95% homology between pmGT2 and the rat Yb2 (subunit 4) gene [1].
  • Consistent with this possibility, associations between the glutathione S-transferase-mu-null phenotype and increased risk for lung, larynx, and bladder cancer have been recently demonstrated in humans [4].
  • Our murine studies suggest that the chemopreventive activity of oltipraz may be due in part to its ability to elevate glutathione S-transferase-mu activity [4].
  • In 62.5% of the mononuclear blood cells from controls, glutathione S-transferase mu is present [2].

Biological context of Gstm1


Anatomical context of Gstm1


Associations of Gstm1 with chemical compounds


Analytical, diagnostic and therapeutic context of Gstm1


  1. Isolation, characterization, and expression in Escherichia coli of two murine Mu class glutathione S-transferase cDNAs homologous to the rat subunits 3 (Yb1) and 4 (Yb2). Townsend, A.J., Goldsmith, M.E., Pickett, C.B., Cowan, K.H. J. Biol. Chem. (1989) [Pubmed]
  2. Immunodetection with a monoclonal antibody of glutathione S-transferase mu in patients with and without carcinomas. Peters, W.H., Kock, L., Nagengast, F.M., Roelofs, H.M. Biochem. Pharmacol. (1990) [Pubmed]
  3. Attenuation of catalase activity in the malignant phenotype plays a functional role in an in vitro model for tumor progression. Gupta, A., Butts, B., Kwei, K.A., Dvorakova, K., Stratton, S.P., Briehl, M.M., Bowden, G.T. Cancer Lett. (2001) [Pubmed]
  4. Coordinate induction of glutathione S-transferase alpha, mu, and pi expression in murine liver after a single administration of oltipraz. Clapper, M.L., Everley, L.C., Strobel, L.A., Townsend, A.J., Engstrom, P.F. Mol. Pharmacol. (1994) [Pubmed]
  5. Characterization of phenotypes in Gstm1-null mice by cytosolic and in vivo metabolic studies using 1,2-dichloro-4-nitrobenzene. Fujimoto, K., Arakawa, S., Shibaya, Y., Miida, H., Ando, Y., Yasumo, H., Hara, A., Uchiyama, M., Iwabuchi, H., Takasaki, W., Manabe, S., Yamoto, T. Drug Metab. Dispos. (2006) [Pubmed]
  6. Gene for glutathione S-transferase-1 (GST1) is on human chromosome 11. Silberstein, D.L., Shows, T.B. Somatic Cell Genet. (1982) [Pubmed]
  7. Altered expression of resistance associated genes in hepatoblastoma xenografts incorporated into mice following treatment with adriamycin or cisplatin. Bader, P., Fuchs, J., Wenderoth, M., von Schweinitz, D., Niethammer, D., Beck, J.F. Anticancer Res. (1998) [Pubmed]
  8. Production and characterization of a monoclonal antibody against Schistosoma japonicum glutathione S-transferase. Campbell, M.J., McFall, P., Niederhuber, J.E. J. Immunol. Methods (1995) [Pubmed]
  9. Selection of effective antisense oligodeoxynucleotides with a green fluorescent protein-based assay. Discovery of selective and potent inhibitors of glutathione S-transferase Mu expression. 't Hoen, P.A., Rosema, B.S., Commandeur, J.N., Vermeulen, N.P., Manoharan, M., van Berkel, T.J., Biessen, E.A., Bijsterbosch, M.K. Eur. J. Biochem. (2002) [Pubmed]
WikiGenes - Universities