The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Edecrin     2-[2,3-dichloro-4-(2- methylidenebutanoyl)p...

Synonyms: Crinuryl, Edecrina, Endecril, Taladren, Hydromedin, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Edecrin


Psychiatry related information on Edecrin


High impact information on Edecrin


Chemical compound and disease context of Edecrin


Biological context of Edecrin


Anatomical context of Edecrin


Associations of Edecrin with other chemical compounds


Gene context of Edecrin

  • Moreover, combined expression of GSTP1-1 and MRP conferred a high level of resistance to ethacrynic acid that was greater than resistance conferred by either protein alone [31].
  • These data indicate that ethacrynic acid inhibits activation of the NF-kappaB pathway at multiple points and suggest that this well-studied drug warrants further investigation as a potential therapeutic for various conditions that are associated with excessive inflammation [32].
  • Furthermore, addition of ethacrynic acid or laurylamine, compounds which inhibit GST and EH, respectively, did not affect the adduct levels [33].
  • The differentiation of HL-60 cells induced by all-trans retinoic acid, dimethyl sulfoxide or phorbol-12-myristate 13-acetate was also enhanced by ethacrynic acid with increasing NBT-reducing and lysozyme activities and the expression of CD11b or CD14 surface antigen [34].
  • A human oxidoreductase (H-37) that is overexpressed in ethacrynic acid-resistant HT29 colon cells (Ciaccio, P. J., Stuart, J.E., and Tew, K.D. (1993) Mol. Pharmacol. 43, 845-853) has been identified as a dihydrodiol dehydrogenase [23].

Analytical, diagnostic and therapeutic context of Edecrin


  1. Phase I study of thiotepa in combination with the glutathione transferase inhibitor ethacrynic acid. O'Dwyer, P.J., LaCreta, F., Nash, S., Tinsley, P.W., Schilder, R., Clapper, M.L., Tew, K.D., Panting, L., Litwin, S., Comis, R.L. Cancer Res. (1991) [Pubmed]
  2. Role of glutathione S-transferases in the resistance of human colon cancer cell lines to doxorubicin. Beaumont, P.O., Moore, M.J., Ahmad, K., Payne, M.M., Lee, C., Riddick, D.S. Cancer Res. (1998) [Pubmed]
  3. The nature of the negative endocochlear potentials produced by anoxia and ethacrynic acid in the rat and guinea-pig. Bosher, S.K. J. Physiol. (Lond.) (1979) [Pubmed]
  4. Filtered bicarbonate and plasma pH as determinants of renal bicarbonate reabsorption. Langberg, H., Mathisen, O., Holdaas, H., Kiil, F. Kidney Int. (1981) [Pubmed]
  5. Design, synthesis, and testing of potential antisickling agents. 7. Ethacrynic acid analogues. Abraham, D.J., Mehanna, A.S., Williams, F.S., Cragoe, E.J., Woltersdorf, O.W. J. Med. Chem. (1989) [Pubmed]
  6. Effects of chronic ethacrynic acid exposure on glutathione conjugation and MRP expression in human colon tumor cells. Ciaccio, P.J., Shen, H., Kruh, G.D., Tew, K.D. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  7. Memory consolidation: further evidence for the four-phase model from the time-courses of diethyldithiocarbamate and ethacrynic acid amnesias. Frieder, B., Allweis, C. Physiol. Behav. (1982) [Pubmed]
  8. Effect of dehydration on renal blood flow in dog. Kirkebo, A., Tyssebotn, I. Acta Physiol. Scand. (1977) [Pubmed]
  9. Chloride ion efflux regulates adherence, spreading, and respiratory burst of neutrophils stimulated by tumor necrosis factor-alpha (TNF) on biologic surfaces. Menegazzi, R., Busetto, S., Dri, P., Cramer, R., Patriarca, P. J. Cell Biol. (1996) [Pubmed]
  10. The acute hemodynamic effects of ethacrynic acid and furosemide in patients with chronic postcapillary pulmonary hypertension. Austin, S.M., Schreiner, B.F., Kramer, D.H., Shah, P.M., Yu, P.N. Circulation (1976) [Pubmed]
  11. Effects of diuretics on inner medullary hemodynamics in the dog. Spitalewitz, S., Chou, S.Y., Faubert, P.F., Porush, J.G. Circ. Res. (1982) [Pubmed]
  12. Studies on the nature of a prostaglandin receptor in canine and rabbit vascular smooth muscle. Greenberg, S., Kadowitz, P.J., Long, J.P., Wilson, W.R. Circ. Res. (1976) [Pubmed]
  13. Detection of drug-induced apoptosis and necrosis in human cervical carcinoma cells using 1H NMR spectroscopy. Bezabeh, T., Mowat, M.R., Jarolim, L., Greenberg, A.H., Smith, I.C. Cell Death Differ. (2001) [Pubmed]
  14. Hypernatremia inhibits NaHCO3 reabsorption and associated NaCl reabsorption in dogs. Langberg, H., Hartmann, A., Ostensen, J., Mathisen, O., Kiil, F. Kidney Int. (1986) [Pubmed]
  15. Zidovudine azido-reductase in human liver microsomes: activation by ethacrynic acid, dipyridamole, and indomethacin and inhibition by human immunodeficiency virus protease inhibitors. Fayz, S., Inaba, T. Antimicrob. Agents Chemother. (1998) [Pubmed]
  16. Selenium and drug metabolism--III. Relation of glutathione-peroxidase and other hepatic enzyme modulations to dietary supplements. Reiter, R., Wendel, A. Biochem. Pharmacol. (1985) [Pubmed]
  17. Comparison of the cochlear toxicity of sodium ethacrynate, furosemide, and the cysteine adduct of sodium ethacrynate in cats. Brown, R.D. Toxicol. Appl. Pharmacol. (1975) [Pubmed]
  18. Sensitization to the cytotoxicity of melphalan by ethacrynic acid and hyperthermia in drug-sensitive and multidrug-resistant Chinese hamster ovary cells. Turcotte, S., Averill-Bates, D.A. Radiat. Res. (2001) [Pubmed]
  19. Volume-sensitive chloride channels do not mediate activation-induced chloride efflux in human neutrophils. Perez-Cornejo, P., Arreola, J., Law, F.Y., Schultz, J.B., Knauf, P.A. J. Immunol. (2004) [Pubmed]
  20. Ethacrynic-acid-induced glutathione depletion and oxidative stress in normal and Mrp2-deficient rat liver. Ji, B., Ito, K., Sekine, S., Tajima, A., Horie, T. Free Radic. Biol. Med. (2004) [Pubmed]
  21. The effect of inhibition of glutathione S-transferase P on the growth of the Jurkat human T cell line. McCaughan, F.M., Brown, A.L., Harrison, D.J. J. Pathol. (1994) [Pubmed]
  22. Biochemical characterization of resistance to mitoxantrone and adriamycin in Caco-2 human colon adenocarcinoma cells: a possible role for glutathione S-transferases. Peters, W.H., Roelofs, H.M. Cancer Res. (1992) [Pubmed]
  23. Regulation of human dihydrodiol dehydrogenase by Michael acceptor xenobiotics. Ciaccio, P.J., Jaiswal, A.K., Tew, K.D. J. Biol. Chem. (1994) [Pubmed]
  24. Induction and suppression of glutathione transferases by interferon in the mouse. Adams, D.J., Balkwill, F.R., Griffin, D.B., Hayes, J.D., Lewis, A.D., Wolf, C.R. J. Biol. Chem. (1987) [Pubmed]
  25. Connective tissue activation. IX. Modification by pharmacologic agents. Castor, C.W. Arthritis Rheum. (1975) [Pubmed]
  26. Oxidative stress and Mrp2 internalization. Sekine, S., Ito, K., Horie, T. Free Radic. Biol. Med. (2006) [Pubmed]
  27. Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic. Liu, J., Chen, H., Miller, D.S., Saavedra, J.E., Keefer, L.K., Johnson, D.R., Klaassen, C.D., Waalkes, M.P. Mol. Pharmacol. (2001) [Pubmed]
  28. Mode of stimulation by adenosine 3':5'-cyclic monophosphate of the sodium efflux in barnacle muscle fibres. Bittar, E.E., Chambers, G., Schultz, R. J. Physiol. (Lond.) (1976) [Pubmed]
  29. The effect of external ethacrynic acid and ouabain on the concentration and distribution of sodium, potassium and chloride in the amphibian oocyte measured by electron microprobe X-ray analysis [proceedings]. Dick, D.A., Ibrahim, K.B. J. Physiol. (Lond.) (1979) [Pubmed]
  30. The high non-enzymatic conjugation rates of some glutathione S-transferase (GST) substrates at high glutathione concentrations. Satoh, K. Carcinogenesis (1995) [Pubmed]
  31. Combined expression of multidrug resistance protein (MRP) and glutathione S-transferase P1-1 (GSTP1-1) in MCF7 cells and high level resistance to the cytotoxicities of ethacrynic acid but not oxazaphosphorines or cisplatin. Morrow, C.S., Smitherman, P.K., Townsend, A.J. Biochem. Pharmacol. (1998) [Pubmed]
  32. Ethacrynic acid inhibits multiple steps in the NF-kappaB signaling pathway. Han, Y., Englert, J.A., Delude, R.L., Fink, M.P. Shock (2005) [Pubmed]
  33. In vitro studies of the influence of glutathione transferases and epoxide hydrolase on the detoxification of acrylamide and glycidamide in blood. Paulsson, B., Rannug, A., Henderson, A.P., Golding, B.T., Törnqvist, M., Warholm, M. Mutat. Res. (2005) [Pubmed]
  34. Ethacrynic acid and 1 alpha,25-dihydroxyvitamin D3 cooperatively inhibit proliferation and induce differentiation of human myeloid leukemia cells. Makishima, M., Honma, Y. Leuk. Res. (1996) [Pubmed]
  35. Multifactorial mechanisms associated with broad cross-resistance of ovarian carcinoma cells selected by cyanomorpholino doxorubicin. Lau, D.H., Lewis, A.D., Ehsan, M.N., Sikic, B.I. Cancer Res. (1991) [Pubmed]
  36. Overproduction of a 37.5-kDa cytosolic protein structurally related to prostaglandin F synthase in ethacrynic acid-resistant human colon cells. Ciaccio, P.J., Stuart, J.E., Tew, K.D. Mol. Pharmacol. (1993) [Pubmed]
  37. Lacrimal gland flow and potentials during dinitrophenol, ouabain, and ethacrynic acid perfusion. Botelho, S.Y., Fuenmayor, N. Invest. Ophthalmol. Vis. Sci. (1981) [Pubmed]
  38. Changes in mitochondrial shape and distribution induced by ethacrynic acid and the transient formation of a mitochondrial reticulum. Soltys, B.J., Gupta, R.S. J. Cell. Physiol. (1994) [Pubmed]
  39. Influence of ethacrynic acid on intrarenal renin release mechanisms. Eide, I., Loyning, E., Langård, O., Kiil, F. Kidney Int. (1975) [Pubmed]
WikiGenes - Universities