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Chemical Compound Review

Edecrin     2-[2,3-dichloro-4-(2- methylidenebutanoyl)p...

Synonyms: Crinuryl, Edecrina, Endecril, Taladren, Hydromedin, ...
 
 
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Disease relevance of Edecrin

 

Psychiatry related information on Edecrin

 

High impact information on Edecrin

 

Chemical compound and disease context of Edecrin

 

Biological context of Edecrin

 

Anatomical context of Edecrin

 

Associations of Edecrin with other chemical compounds

 

Gene context of Edecrin

  • Moreover, combined expression of GSTP1-1 and MRP conferred a high level of resistance to ethacrynic acid that was greater than resistance conferred by either protein alone [31].
  • These data indicate that ethacrynic acid inhibits activation of the NF-kappaB pathway at multiple points and suggest that this well-studied drug warrants further investigation as a potential therapeutic for various conditions that are associated with excessive inflammation [32].
  • Furthermore, addition of ethacrynic acid or laurylamine, compounds which inhibit GST and EH, respectively, did not affect the adduct levels [33].
  • The differentiation of HL-60 cells induced by all-trans retinoic acid, dimethyl sulfoxide or phorbol-12-myristate 13-acetate was also enhanced by ethacrynic acid with increasing NBT-reducing and lysozyme activities and the expression of CD11b or CD14 surface antigen [34].
  • A human oxidoreductase (H-37) that is overexpressed in ethacrynic acid-resistant HT29 colon cells (Ciaccio, P. J., Stuart, J.E., and Tew, K.D. (1993) Mol. Pharmacol. 43, 845-853) has been identified as a dihydrodiol dehydrogenase [23].
 

Analytical, diagnostic and therapeutic context of Edecrin

References

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  2. Role of glutathione S-transferases in the resistance of human colon cancer cell lines to doxorubicin. Beaumont, P.O., Moore, M.J., Ahmad, K., Payne, M.M., Lee, C., Riddick, D.S. Cancer Res. (1998) [Pubmed]
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  7. Memory consolidation: further evidence for the four-phase model from the time-courses of diethyldithiocarbamate and ethacrynic acid amnesias. Frieder, B., Allweis, C. Physiol. Behav. (1982) [Pubmed]
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  13. Detection of drug-induced apoptosis and necrosis in human cervical carcinoma cells using 1H NMR spectroscopy. Bezabeh, T., Mowat, M.R., Jarolim, L., Greenberg, A.H., Smith, I.C. Cell Death Differ. (2001) [Pubmed]
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  15. Zidovudine azido-reductase in human liver microsomes: activation by ethacrynic acid, dipyridamole, and indomethacin and inhibition by human immunodeficiency virus protease inhibitors. Fayz, S., Inaba, T. Antimicrob. Agents Chemother. (1998) [Pubmed]
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  19. Volume-sensitive chloride channels do not mediate activation-induced chloride efflux in human neutrophils. Perez-Cornejo, P., Arreola, J., Law, F.Y., Schultz, J.B., Knauf, P.A. J. Immunol. (2004) [Pubmed]
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  23. Regulation of human dihydrodiol dehydrogenase by Michael acceptor xenobiotics. Ciaccio, P.J., Jaiswal, A.K., Tew, K.D. J. Biol. Chem. (1994) [Pubmed]
  24. Induction and suppression of glutathione transferases by interferon in the mouse. Adams, D.J., Balkwill, F.R., Griffin, D.B., Hayes, J.D., Lewis, A.D., Wolf, C.R. J. Biol. Chem. (1987) [Pubmed]
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  27. Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic. Liu, J., Chen, H., Miller, D.S., Saavedra, J.E., Keefer, L.K., Johnson, D.R., Klaassen, C.D., Waalkes, M.P. Mol. Pharmacol. (2001) [Pubmed]
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  29. The effect of external ethacrynic acid and ouabain on the concentration and distribution of sodium, potassium and chloride in the amphibian oocyte measured by electron microprobe X-ray analysis [proceedings]. Dick, D.A., Ibrahim, K.B. J. Physiol. (Lond.) (1979) [Pubmed]
  30. The high non-enzymatic conjugation rates of some glutathione S-transferase (GST) substrates at high glutathione concentrations. Satoh, K. Carcinogenesis (1995) [Pubmed]
  31. Combined expression of multidrug resistance protein (MRP) and glutathione S-transferase P1-1 (GSTP1-1) in MCF7 cells and high level resistance to the cytotoxicities of ethacrynic acid but not oxazaphosphorines or cisplatin. Morrow, C.S., Smitherman, P.K., Townsend, A.J. Biochem. Pharmacol. (1998) [Pubmed]
  32. Ethacrynic acid inhibits multiple steps in the NF-kappaB signaling pathway. Han, Y., Englert, J.A., Delude, R.L., Fink, M.P. Shock (2005) [Pubmed]
  33. In vitro studies of the influence of glutathione transferases and epoxide hydrolase on the detoxification of acrylamide and glycidamide in blood. Paulsson, B., Rannug, A., Henderson, A.P., Golding, B.T., Törnqvist, M., Warholm, M. Mutat. Res. (2005) [Pubmed]
  34. Ethacrynic acid and 1 alpha,25-dihydroxyvitamin D3 cooperatively inhibit proliferation and induce differentiation of human myeloid leukemia cells. Makishima, M., Honma, Y. Leuk. Res. (1996) [Pubmed]
  35. Multifactorial mechanisms associated with broad cross-resistance of ovarian carcinoma cells selected by cyanomorpholino doxorubicin. Lau, D.H., Lewis, A.D., Ehsan, M.N., Sikic, B.I. Cancer Res. (1991) [Pubmed]
  36. Overproduction of a 37.5-kDa cytosolic protein structurally related to prostaglandin F synthase in ethacrynic acid-resistant human colon cells. Ciaccio, P.J., Stuart, J.E., Tew, K.D. Mol. Pharmacol. (1993) [Pubmed]
  37. Lacrimal gland flow and potentials during dinitrophenol, ouabain, and ethacrynic acid perfusion. Botelho, S.Y., Fuenmayor, N. Invest. Ophthalmol. Vis. Sci. (1981) [Pubmed]
  38. Changes in mitochondrial shape and distribution induced by ethacrynic acid and the transient formation of a mitochondrial reticulum. Soltys, B.J., Gupta, R.S. J. Cell. Physiol. (1994) [Pubmed]
  39. Influence of ethacrynic acid on intrarenal renin release mechanisms. Eide, I., Loyning, E., Langård, O., Kiil, F. Kidney Int. (1975) [Pubmed]
 
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