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Chemical Compound Review

CHEMBL300004     (1R,2R,3R,4S,5R,8R,9S,10R,11R) -2-[(2S,3R...

Synonyms: EM-201, ME 4, SureCN12101978, EM523, LS-174415, ...
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Disease relevance of EM-523


Psychiatry related information on EM-523

  • We investigated the effect of an erythromycin derivative, EM523L, on interdigestive gastrointestinal motor activity and plasma motilin concentrations in three healthy volunteers using an infused catheter system [2].

High impact information on EM-523


Chemical compound and disease context of EM-523


Biological context of EM-523

  • A dose of 2 mg EM523L was administered IV over 15 min just after ingestion of a solid meal (200 kcal Gastric emptying was measured by a radionuclide technique [7].

Anatomical context of EM-523


Gene context of EM-523


Analytical, diagnostic and therapeutic context of EM-523

  • The contractile response to EM-523 or motilin was reduced markedly after treatment of the preparation with a high concentration of either agent, and cross-tachyphylaxis between EM-523 and motilin was also observed [5].
  • A total of 2 mg of EM523L dissolved in 100 mL of physiologic saline was administered by intravenous infusion over a period of 15 minutes after ingestion of the test meal [6].


  1. An erythromycin derivative, EM-523, induces motilin-like gastrointestinal motility in dogs. Inatomi, N., Satoh, H., Maki, Y., Hashimoto, N., Itoh, Z., Omura, S. J. Pharmacol. Exp. Ther. (1989) [Pubmed]
  2. Effect of erythromycin derivative EM523L on human interdigestive gastrointestinal tract. Kawamura, O., Sekiguchi, T., Itoh, Z., Omura, S. Dig. Dis. Sci. (1993) [Pubmed]
  3. Mechanism of gastroprokinetic effect of EM523, an erythromycin derivative, in dogs. Ohtawa, M., Mizumoto, A., Hayashi, N., Yanagida, K., Itoh, Z., Omura, S. Gastroenterology (1993) [Pubmed]
  4. Synthesis of 4"-deoxy motilides: identification of a potent and orally active prokinetic drug candidate. Lartey, P.A., Nellans, H.N., Faghih, R., Petersen, A., Edwards, C.M., Freiberg, L., Quigley, S., Marsh, K., Klein, L.L., Plattner, J.J. J. Med. Chem. (1995) [Pubmed]
  5. EM-523, an erythromycin derivative, and motilin show similar contractile activity in isolated rabbit intestine. Satoh, T., Inatomi, N., Satoh, H., Marui, S., Itoh, Z., Omura, S. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
  6. Effect of intravenous administration of EM523L on gastric emptying and plasma glucose levels after a meal in patients with diabetic gastroparesis: a pilot study. Nakamura, T., Ishii, M., Arai, Y., Tandoh, Y., Terada, A., Takebe, K. Clinical therapeutics. (1994) [Pubmed]
  7. EM523L, a nonpeptide motilin agonist, stimulates gastric emptying and pancreatic polypeptide secretion. Okano, H., Inui, A., Ueno, N., Morimoto, S., Ohmoto, A., Miyamoto, M., Aoyama, N., Nakajima, Y., Baba, S., Kasuga, M. Peptides (1996) [Pubmed]
  8. The erythromycin derivative EM-523 is a potent motilin agonist in man and in rabbit. Depoortere, I., Peeters, T.L., Vantrappen, G. Peptides (1990) [Pubmed]
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