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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Ileus


High impact information on Ileus


Chemical compound and disease context of Ileus


Biological context of Ileus


Anatomical context of Ileus


Gene context of Ileus

  • Differential salutary effects of nonselective and selective COX-2 inhibitors in postoperative ileus in rats [23].
  • Endogenous CRF in the brain plays a role in mediating various forms of stressor-induced gastric stasis, including postoperative gastric ileus, and activates colonic transit and fecal excretion elicited by psychologically aversive or fearful stimuli [24].
  • The intestines of Cftr deficient mice (CF mice: Cftrtm1Unc) are prone to obstruction by excessive mucus accumulation and are used as a model of meconium ileus and distal intestinal obstruction syndrome [25].
  • CONCLUSIONS: Prostaglandins, through the induction of COX-2, are major participants in rodent postoperative ileus induced by intestinal manipulation [26].
  • Therefore, we tested the protective effects of inhaled carbon monoxide (CO) and an endogenous haeme oxygenase 1 (HO-1) anti-inflammatory mediator on transplant induced inflammatory responses and intestinal ileus in the rat [27].

Analytical, diagnostic and therapeutic context of Ileus


  1. Meconium ileus equivalent complicating cystic fibrosis in postneonatal children and young adults. Report of 12 cases. Matsehe, J.W., Go, V.L., DiMagno, E.P. Gastroenterology (1977) [Pubmed]
  2. Fedotozine reverses ileus induced by surgery or peritonitis: action at peripheral kappa-opioid receptors. Rivière, P.J., Pascaud, X., Chevalier, E., Le Gallou, B., Junien, J.L. Gastroenterology (1993) [Pubmed]
  3. Cystic fibrosis patients bearing both the common missense mutation Gly----Asp at codon 551 and the delta F508 mutation are clinically indistinguishable from delta F508 homozygotes, except for decreased risk of meconium ileus. Hamosh, A., King, T.M., Rosenstein, B.J., Corey, M., Levison, H., Durie, P., Tsui, L.C., McIntosh, I., Keston, M., Brock, D.J. Am. J. Hum. Genet. (1992) [Pubmed]
  4. Defective regulatory volume decrease in human cystic fibrosis tracheal cells because of altered regulation of intermediate conductance Ca2+-dependent potassium channels. Vázquez, E., Nobles, M., Valverde, M.A. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  5. Quantitative evaluation of the development of the exocrine pancreas in cystic fibrosis and control infants. Imrie, J.R., Fagan, D.G., Sturgess, J.M. Am. J. Pathol. (1979) [Pubmed]
  6. Myxedema ileus. A form of intestinal pseudo-obstruction. Abbasi, A.A., Douglass, R.C., Bissell, G.W., Chen, Y. JAMA (1975) [Pubmed]
  7. Corticotropin-releasing factor receptor 1-deficient mice do not develop postoperative gastric ileus. Luckey, A., Wang, L., Jamieson, P.M., Basa, N.R., Million, M., Czimmer, J., Vale, W., Taché, Y. Gastroenterology (2003) [Pubmed]
  8. Inhaled carbon monoxide suppresses the development of postoperative ileus in the murine small intestine. Moore, B.A., Otterbein, L.E., Türler, A., Choi, A.M., Bauer, A.J. Gastroenterology (2003) [Pubmed]
  9. Lipopolysaccharide preconditioning and cross-tolerance: the induction of protective mechanisms for rat intestinal ileus. Schwarz, N.T., Engel, B., Eskandari, M.K., Kalff, J.C., Grandis, J.R., Bauer, A.J. Gastroenterology (2002) [Pubmed]
  10. Small bowel motility following major intra-abdominal surgery: the effects of opiates and rectal cisapride. Benson, M.J., Roberts, J.P., Wingate, D.L., Rogers, J., Deeks, J.J., Castillo, F.D., Williams, N.S. Gastroenterology (1994) [Pubmed]
  11. Inhibition of gastrointestinal transit due to surgical trauma or peritoneal irritation is reduced in capsaicin-treated rats. Holzer, P., Lippe, I.T., Holzer-Petsche, U. Gastroenterology (1986) [Pubmed]
  12. Loperamide-induced ileus. von Mühlendahl, K.E., Bunjes, R., Krienke, E.G. Lancet (1980) [Pubmed]
  13. Does cimetidine cause ileus in the burned patient? Watson, W.C., Kutty, P.K., Colcleugh, R.G. Lancet (1977) [Pubmed]
  14. Liver disease in cystic fibrosis: A prospective study on incidence, risk factors, and outcome. Colombo, C., Battezzati, P.M., Crosignani, A., Morabito, A., Costantini, D., Padoan, R., Giunta, A. Hepatology (2002) [Pubmed]
  15. Inflammation of the cystic fibrosis mouse small intestine. Norkina, O., Kaur, S., Ziemer, D., De Lisle, R.C. Am. J. Physiol. Gastrointest. Liver Physiol. (2004) [Pubmed]
  16. Recovery of gastrointestinal motility from post-operative ileus in dogs: effects of Leu13-motilin (KW-5139) and prostaglandin F2 alpha. Yokoyama, T., Kitazawa, T., Takasaki, K., Ishii, A., Karasawa, A. Neurogastroenterol. Motil. (1995) [Pubmed]
  17. Neostigmine resolves critical illness-related colonic ileus in intensive care patients with multiple organ failure--a prospective, double-blind, placebo-controlled trial. van der Spoel, J.I., Oudemans-van Straaten, H.M., Stoutenbeek, C.P., Bosman, R.J., Zandstra, D.F. Intensive care medicine. (2001) [Pubmed]
  18. Does metoclopramide reduce the length of ileus after colorectal surgery? A prospective randomized trial. Cheape, J.D., Wexner, S.D., James, K., Jagelman, D.G. Dis. Colon Rectum (1991) [Pubmed]
  19. MCP-1 causes leukocyte recruitment and subsequently endotoxemic ileus in rat. Türler, A., Schwarz, N.T., Türler, E., Kalff, J.C., Bauer, A.J. Am. J. Physiol. Gastrointest. Liver Physiol. (2002) [Pubmed]
  20. CGRP antagonists and capsaicin on celiac ganglia partly prevent postoperative gastric ileus. Plourde, V., Wong, H.C., Walsh, J.H., Raybould, H.E., Taché, Y. Peptides (1993) [Pubmed]
  21. Intraperitoneal capsaicin treatment reduces postoperative gastric ileus in awake rats. Zittel, T.T., Meile, T., Jehle, E.C., Becker, H.D. Langenbeck's archives of surgery / Deutsche Gesellschaft für Chirurgie. (2001) [Pubmed]
  22. Systemic capsaicin inhibits neuronal activation in the brainstem during postoperative ileus in the mouse. Mueller, M.H., Kampitoglou, D., Glatzle, J., Hahn, J., Kreis, M.E. Langenbeck's archives of surgery / Deutsche Gesellschaft für Chirurgie. (2006) [Pubmed]
  23. Differential salutary effects of nonselective and selective COX-2 inhibitors in postoperative ileus in rats. Korolkiewicz, R.P., Ujda, M., Dabkowski, J., Ruczyński, J., Rekowski, P., Petrusewicz, J. J. Surg. Res. (2003) [Pubmed]
  24. Corticotropin-releasing factor and the brain-gut motor response to stress. Taché, Y., Martinez, V., Million, M., Rivier, J. Can. J. Gastroenterol. (1999) [Pubmed]
  25. Potential genetic modifiers of the cystic fibrosis intestinal inflammatory phenotype on mouse chromosomes 1, 9, and 10. Norkina, O., De Lisle, R.C. BMC Genet. (2005) [Pubmed]
  26. Prostanoid production via COX-2 as a causative mechanism of rodent postoperative ileus. Schwarz, N.T., Kalff, J.C., Türler, A., Engel, B.M., Watkins, S.C., Billiar, T.R., Bauer, A.J. Gastroenterology (2001) [Pubmed]
  27. Immunomodulatory effects of inhaled carbon monoxide on rat syngeneic small bowel graft motility. Nakao, A., Moore, B.A., Murase, N., Liu, F., Zuckerbraun, B.S., Bach, F.H., Choi, A.M., Nalesnik, M.A., Otterbein, L.E., Bauer, A.J. Gut (2003) [Pubmed]
  28. The effects of metoclopramide on postoperative ileus. A randomized double-blind study. Davidson, E.D., Hersh, T., Brinner, R.A., Barnett, S.M., Boyle, L.P. Ann. Surg. (1979) [Pubmed]
  29. Vasopressin effects on the small intestine: a possible factor in paralytic ileus? Mitchell, A., Collin, J. The British journal of surgery. (1985) [Pubmed]
  30. Epidural anesthesia accelerates the recovery of postischemic bowel motility in the rat. Udassin, R., Eimerl, D., Schiffman, J., Haskel, Y. Anesthesiology (1994) [Pubmed]
  31. Liver injury after oral and rectal administration of N-acetylcysteine for meconium ileus equivalent in a patient with cystic fibrosis. Bailey, D.J., Andres, J.M. Pediatrics (1987) [Pubmed]
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