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Chemical Compound Review

CCG-37848     [4-[(4-dimethylaminophenyl)- (2-hydroxy-3,6...

Synonyms: NSC-11237, NSC-71959, AC1L3LZD, NCI11237, NSC71959, ...
 
 
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Disease relevance of Acid Leather Green S

  • Variant rat pheochromocytoma (PC12) cells which fail to respond to nerve growth factor (NGF) (PC12nnr5) (Green, S. H., R. E. Rydel, J. L. Connoly, and L. A. Greene. 1986. J. Cell Biol. 102:830-843) bind NGF at both high and low affinity sites [1].
  • It is concluded that the no-untoward-effect level in this study is 500 mg Green S/kg body weight/day [2].
  • Long-term toxicity study of Green S in mice [3].
 

High impact information on Acid Leather Green S

 

Biological context of Acid Leather Green S

  • The F0 generation first received Green S as weanlings, but succeeding generations were exposed throughout life, including in utero, as treatment continued during gestation and lactation [2].
 

Anatomical context of Acid Leather Green S

  • No definite abnormalities were seen and the only finding in the examination of stained skeletons was a slightly more advanced ossification of the forelimbs of the offspring from females given 500 or 1000 mg Green S/kg/day [8].
  • With a dose of 1500 mg Green S/kg a greater proportion of the rats showed higher urinary protein, protein casts, increased caecal weight, thyroid degeneration in female animals and enlargement of the lymph nodes in the intestine wall [9].
  • Of the dyes tested, Aniline Blue and the permitted food dye Green S as 1% solutions were the most suitable when added to semen with milk buffer diluent [10].
 

Associations of Acid Leather Green S with other chemical compounds

 

Gene context of Acid Leather Green S

References

  1. Nerve growth factor nonresponsive pheochromocytoma cells: altered internalization results in signaling dysfunction. Eveleth, D.D., Bradshaw, R.A. J. Cell Biol. (1992) [Pubmed]
  2. Three-generation toxicity study of rats ingesting Green S in the diet. Moorhouse, S.R., Creasy, D.M., Gaunt, I.F. Food Chem. Toxicol. (1987) [Pubmed]
  3. Long-term toxicity study of Green S in mice. Brantom, P.G., Creasy, D.M., Gaunt, I.F. Food Chem. Toxicol. (1987) [Pubmed]
  4. Suicide by order: some open questions about the cell-killing activities of the TNF ligand and receptor families. Wallach, D. Cytokine Growth Factor Rev. (1996) [Pubmed]
  5. The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein. Opipari, A.W., Boguski, M.S., Dixit, V.M. J. Biol. Chem. (1990) [Pubmed]
  6. Sister chromatid exchange and chromosome aberrations in mice after in vivo exposure of green S--a food colorant. Giri, A.K., Sivam, S.S., Khan, K.A., Sethi, N. Environ. Mol. Mutagen. (1992) [Pubmed]
  7. Mutagenicity of arylmethane dyes in Salmonella. Bonin, A.M., Farquharson, J.B., Baker, R.S. Mutat. Res. (1981) [Pubmed]
  8. Teratogenicity and embryotoxicity study of Green S in rats. Clode, S.A. Food Chem. Toxicol. (1987) [Pubmed]
  9. Short-term toxicity study of Green S in rats. Clode, S.A., Gaunt, I.F., Hendy, R.J., Cottrell, R.C., Gangolli, S.D. Food Chem. Toxicol. (1987) [Pubmed]
  10. Selection of a dye for use in semen transport studies in the cow. Devine, D.A., Isbister, J., Lindsay, F.E., Boyd, H. Theriogenology (1986) [Pubmed]
  11. The metabolic disposition of 14C-labelled green S and Brilliant Blue FCF in the rat, mouse and guinea-pig. Phillips, J.C., Mendis, D., Eason, C.T., Gangolli, S.D. Food and cosmetics toxicology. (1980) [Pubmed]
  12. The photosystem I-like P840-reaction center of green S-bacteria is a homodimer. Büttner, M., Xie, D.L., Nelson, H., Pinther, W., Hauska, G., Nelson, N. Biochim. Biophys. Acta (1992) [Pubmed]
 
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