Disease relevance of Food Hypersensitivity

• Rises in plasma histamine that were seen after these positive oral food challenges implicate mast-cell or basophil mediators in the pathogenesis of food allergy, including cutaneous changes in patients with atopic dermatitis [1].
• Prevalence of eczema at ages 1 and 3 years was lowest (p = 0.03, ANOVA) in the prolonged breastfeeding group, prevalence of food allergy was highest in the little or no groups (p = 0.02, ANOVA) at 1-3 years, and respiratory allergy was also most prevalent in the latter group (p = 0.01, ANOVA) having risen to 65% at 17 years of age [2].
• These properties make ketotifen suitable for the long-term prophylaxis of bronchial asthma and for the prevention and treatment of other allergic disorders, such as allergic rhinitis and conjunctivitis, food allergy, and urticaria [3].
• METHODS: Pet exposure in the home was compared with cytokine secretion patterns (mitogen-stimulated mononuclear cells at birth and age 1 year) and indicators of atopy (allergen-specific and total IgE, eosinophilia, food allergy, atopic dermatitis) in 285 infants [4].
• Clinicians should be aware of the entity of late onset angioedema caused by C1 esterase deficiency mimicking food allergy and hence delaying the diagnosis of this potentially lethal condition [5].

Psychiatry related information on Food Hypersensitivity

• Latex allergy has resulted in death, progressive asthma, severe food allergy from cross-reactivity, and disability of health care professionals with the accompanied loss of self-esteem and income from their inability to work in their chosen profession [6].

High impact information on Food Hypersensitivity

• Mononuclear cells from persons with food allergies spontaneously produced a histamine-releasing factor in vitro that provoked the release of histamine from the basophils of other food-sensitive persons, but not from those of normal controls [7].
• These results demonstrate that oral allergen-gene immunization with chitosan-DNA nanoparticles is effective in modulating murine anaphylactic responses, and indicate its prophylactic utility in treating food allergy [8].
• AGA technical review on the evaluation of food allergy in gastrointestinal disorders. American Gastroenterological Association [9].
• METHODS: A closed-segment perfusion technique was used to investigate jejunal release of tryptase, histamine, prostaglandin D2, and water flux in response to the cold pressor test in 8 healthy subjects and 9 patients with food allergy [10].
• Tests for antigen entry and immune-complex formation after oral challenge may permit objective assessment of food allergy and may show whether drugs such as oral sodium cromoglycate are likely to benefit individual patients [11].

Chemical compound and disease context of Food Hypersensitivity

• CONCLUSIONS: The prevalence of latex allergy among children admitted for inhalant or food allergy testing was 1% [12].
• Double-blind placebo-controlled trial of oral cromolyn in children with atopic dermatitis and documented food hypersensitivity [13].
• CONCLUSION: These results suggest that probiotic bacteria may promote endogenous barrier mechanisms in patients with atopic dermatitis and food allergy, and by alleviating intestinal inflammation, may act as a useful tool in the treatment of food allergy [14].
• Dramatic augmentation of a food allergy by acetylsalicylic acid [15].
• Cholesterol precursors and plant sterols in children with food allergy [16].

Biological context of Food Hypersensitivity

• To investigate the potential application of allergen gene immunization in the modulation of food allergy, C3H/HeSn (C3H) mice received i.m. injections of pAra h2 plasmid DNA encoding one of the major peanut allergens, Ara h2 [17].
• We investigated whether patients with immunoglobulin E-mediated food allergy differed from healthy individuals with regard to genotype of the polymorphic enzyme N -acetyltransferase 2 (NAT2) [18].
• Epidemiology of food allergy/food intolerance in adults: associations with other manifestations of atopy [19].
• Under these conditions it has been found that proteins known to be associated with food allergy in humans (including peanut proteins and ovalbumin) elicit both specific IgG and IgE antibody responses, measured using enzyme-linked immunosorbant and homologous passive cutaneous anaphylaxis assays, respectively [20].
• Cell counts in the sputum of patients with asthma and in those with food allergy and asthma showed higher eosinophil counts compared to those with food allergy and allergic rhinitis [21].

Anatomical context of Food Hypersensitivity

• PATIENTS/METHODS: In eight patients with food allergy and seven healthy volunteers, a closed-segment perfusion technique was used to investigate the effects of jejunal food challenge on luminal release of tryptase, histamine, prostaglandin D(2), eosinophil cationic protein, peroxidase activity, and water flux [22].
• Low IL-10 production in Peyer patches may favor symptoms of food allergy [23].
• In addition, advances in understanding immune regulation associated with abrogation of oral tolerance in food allergy and of dendritic cell function, modulation of regulatory T cells, and chemokine expression in AD have elucidated possible targets for future intervention [24].
• We initiated this study to evaluate pathological abnormalities and to detect IL-5 in the duodenal mucosa from patients with food allergy [25].
• Our objective was to investigate the presence of a B and T cell immune response directed against the glycine-rich cell wall protein (GRP) in patients with different autoimmune disorders and with food allergy [26].

Gene context of Food Hypersensitivity

• CONCLUSION: These results indicate that oral allergen challenge in atopic patients with food allergy triggers systemic release of IL-10 [27].
• After mitogen stimulation, culture supernatants from patients with food allergy contained significantly less IFN-gamma but increased IL-4 when compared with healthy controls [28].
• These lymphokine abnormalities may contribute to the elevation in IgE and the eosinophilia seen in severe food allergy [29].
• Glucagon-like peptide-2-enhanced barrier function reduces pathophysiology in a model of food allergy [30].
• These results suggest that DEP may act as a mucosal adjuvant in the gut enhancing systemic Th1 and Th2 immune responses and might play a role in oral immunization and food allergy [31].

Analytical, diagnostic and therapeutic context of Food Hypersensitivity

• Sixty-nine patients with one or more positive prick skin tests to legumes (peanut, soybean, green bean, pea, and lima bean) were evaluated for food hypersensitivity with in-hospital oral food challenges [32].
• Currently, the diagnostic work-up of suspected food allergy includes skin prick tests, the measurement of food specific immunoglobulin E (IgE), and the atopy patch test, and double-blind, placebo-controlled food challenges [33].
• Thirty-two children and two adults with chronic atopic dermatitis related to food allergy entered this double-blind crossover study comparing oral sodium cromoglycate (200-1600 mg/24 h) with placebo [34].
• Thus, serologic tests seem to be of low significance for prediction o food allergy in latex-allergic patients [35].
• Allergy immunotherapy (hyposensitization) injections or ibuprofen were implicated as causes of hypersensitivity vasculitis in a dog suffering from probable food allergy [36].

References