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Chemical Compound Review

Suprifen     4-(1-hydroxy-2-methylamino- propyl)phenol

Synonyms: Oxilofrin, Suprifene, Supriphen, Oxilofrina, Oxilofrine, ...
 
 
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Disease relevance of Supriphen

 

High impact information on Supriphen

 

Chemical compound and disease context of Supriphen

 

Biological context of Supriphen

 

Anatomical context of Supriphen

  • The coefficient of variation of HED retention was also greater in paced animals (P=0.05) and was greater in the right atrium than in the left atrium (P=0.004) [12].
 

Associations of Supriphen with other chemical compounds

 

Gene context of Supriphen

 

Analytical, diagnostic and therapeutic context of Supriphen

  • Scintigraphic evaluation of the pattern of cardiac sympathetic innervation in each patient was performed with HED in conjunction with positron emission tomography [1].
  • METHODS: After orthotopic heart transplantation 35 patients (mean age, 49.1 +/- 8.4 years) underwent positron emission tomography with scintigraphically measured uptake of C11-hydroxyephedrine (HED), lung function testing, and cardiopulmonary exercise testing [18].
  • Detection of oxilofrine in plasma and urine by high-performance liquid chromatography with electrochemical detection and comparison with gas chromatography-mass spectrometry [19].
  • A high-performance liquid chromatographic (HPLC) method with electrochemical detection for the determination of oxilofrine [1-(4-hydroxyphenyl)-2-methylaminopropanol] in human plasma and urine (before and after cleavage of the metabolic conjugates) is described [19].
  • Despite normal resting perfusion, significantly reduced HED retention, indicating dysinnervation, was found in 14 of 23 (61%) vascular territories (six of eight patients) [20].

References

  1. Scintigraphic pattern of regional cardiac sympathetic innervation in patients with familial long QT syndrome using positron emission tomography. Calkins, H., Lehmann, M.H., Allman, K., Wieland, D., Schwaiger, M. Circulation (1993) [Pubmed]
  2. Carbon-11 hydroxyephedrine with positron emission tomography for serial assessment of cardiac adrenergic neuronal function after acute myocardial infarction in humans. Allman, K.C., Wieland, D.M., Muzik, O., Degrado, T.R., Wolfe, E.R., Schwaiger, M. J. Am. Coll. Cardiol. (1993) [Pubmed]
  3. Noninvasive assessment of cardiac diabetic neuropathy by carbon-11 hydroxyephedrine and positron emission tomography. Allman, K.C., Stevens, M.J., Wieland, D.M., Hutchins, G.D., Wolfe, E.R., Greene, D.A., Schwaiger, M. J. Am. Coll. Cardiol. (1993) [Pubmed]
  4. Scintigraphic assessment of regionalized defects in myocardial sympathetic innervation and blood flow regulation in diabetic patients with autonomic neuropathy. Stevens, M.J., Dayanikli, F., Raffel, D.M., Allman, K.C., Sandford, T., Feldman, E.L., Wieland, D.M., Corbett, J., Schwaiger, M. J. Am. Coll. Cardiol. (1998) [Pubmed]
  5. Heterogeneous cardiac sympathetic denervation and decreased myocardial nerve growth factor in streptozotocin-induced diabetic rats: implications for cardiac sympathetic dysinnervation complicating diabetes. Schmid, H., Forman, L.A., Cao, X., Sherman, P.S., Stevens, M.J. Diabetes (1999) [Pubmed]
  6. Imaging of cardiac neuronal function after cocaine exposure using carbon-11 hydroxyephedrine and positron emission tomography. Melon, P.G., Nguyen, N., DeGrado, T.R., Mangner, T.J., Wieland, D.M., Schwaiger, M. J. Am. Coll. Cardiol. (1994) [Pubmed]
  7. Relationship between altered sympathetic innervation, oxidative metabolism and contractile function in the cardiomyopathic human heart; a non-invasive study using positron emission tomography. Bengel, F.M., Permanetter, B., Ungerer, M., Nekolla, S.G., Schwaiger, M. Eur. Heart J. (2001) [Pubmed]
  8. Pharmacokinetic parameters and haemodynamic actions of midodrine in young volunteers. Grobecker, H.F., Kees, F. International angiology : a journal of the International Union of Angiology. (1993) [Pubmed]
  9. Dose linearity and relative bioavailability testing of oxilofrine, a sympathicomimetic drug, in healthy volunteers. Verho, M., Malerczyk, V., Kauert, G., Lorenz, H. International journal of clinical pharmacology research. (1988) [Pubmed]
  10. Clinical pharmacokinetics after a single oral dose of oxilofrine. Kauert, G., Angermann, C., Lex, H., Spes, C. International journal of clinical pharmacology research. (1988) [Pubmed]
  11. Studies on drug metabolism by use of isotopes. XXVIII--Biological isotope effect for deuterated ephedrine. Baba, S., Kuroda, Y., Horie, M. Biomed. Environ. Mass Spectrom. (1986) [Pubmed]
  12. Atrial fibrillation produced by prolonged rapid atrial pacing is associated with heterogeneous changes in atrial sympathetic innervation. Jayachandran, J.V., Sih, H.J., Winkle, W., Zipes, D.P., Hutchins, G.D., Olgin, J.E. Circulation (2000) [Pubmed]
  13. Non-invasive assessment of the effect of cardiac sympathetic innervation on metabolism of the human heart. Bengel, F.M., Ueberfuhr, P., Ziegler, S.I., Nekolla, S.G., Odaka, K., Reichart, B., Schwaiger, M. European journal of nuclear medicine. (2000) [Pubmed]
  14. Regional patterns of myocardial sympathetic denervation in dilated cardiomyopathy: an analysis using carbon-11 hydroxyephedrine and positron emission tomography. Hartmann, F., Ziegler, S., Nekolla, S., Hadamitzky, M., Seyfarth, M., Richardt, G., Schwaiger, M. Heart (1999) [Pubmed]
  15. Cardiovascular parameters and catecholamines in volunteers during passive orthostasis. Influence of antihypotensive drugs. Dominiak, P., Kees, F., Welzel, D., Grobecker, H. Arzneimittel-Forschung. (1992) [Pubmed]
  16. Regional pre- and postsynaptic sympathetic system in the failing human heart--regulation of beta ARK-1. Ungerer, M., Weig, H.J., Kübert, S., Overbeck, M., Bengel, F., Schömig, A., Schwaiger, M. Eur. J. Heart Fail. (2000) [Pubmed]
  17. Serial assessment of sympathetic reinnervation after orthotopic heart transplantation. A longitudinal study using PET and C-11 hydroxyephedrine. Bengel, F.M., Ueberfuhr, P., Ziegler, S.I., Nekolla, S., Reichart, B., Schwaiger, M. Circulation (1999) [Pubmed]
  18. Functional significance of cardiac reinnervation in heart transplant recipients. Schwaiblmair, M., von Scheidt, W., Uberfuhr, P., Ziegler, S., Schwaiger, M., Reichart, B., Vogelmeier, C. J. Heart Lung Transplant. (1999) [Pubmed]
  19. Detection of oxilofrine in plasma and urine by high-performance liquid chromatography with electrochemical detection and comparison with gas chromatography-mass spectrometry. Kauert, G., Herrle, I., Schoppek, B. J. Chromatogr. (1988) [Pubmed]
  20. Alterations of myocardial presynaptic sympathetic innervation in patients with multi-vessel coronary artery disease but without history of myocardial infarction. Bulow, H.P., Stahl, F., Lauer, B., Nekolla, S.G., Schuler, G., Schwaiger, M., Bengel, F.M. Nuclear medicine communications. (2003) [Pubmed]
 
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