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Chemical Compound Review

dihydrofolate     (2S)-2-[[4-[(2-amino-4-oxo- 7,8-dihydro-1H...

Synonyms: H2PteGlu, H2folate, FAH2, H2PteGlu1, SureCN8282, ...
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Disease relevance of C00415

  • As 7-hydroxy-MTX is a 200 fold less potent dihydrofolic acid reductase inhibitor compared with MTX decreased production of the metabolite may lead to enhanced clinical toxicity which may not be predictable monitoring MTX serum levels alone [1].

High impact information on C00415


Biological context of C00415


Anatomical context of C00415


Associations of C00415 with other chemical compounds


Gene context of C00415


Analytical, diagnostic and therapeutic context of C00415


  1. 7-Hydroxy-methotrexate and clinical toxicity following high-dose methotrexate therapy. Erttmann, R., Bielack, S., Landbeck, G. J. Cancer Res. Clin. Oncol. (1985) [Pubmed]
  2. Densely methylated DNA islands in mammalian chromosomal replication origins. Tasheva, E.S., Roufa, D.J. Mol. Cell. Biol. (1994) [Pubmed]
  3. Isolation and characterization of dihydrofolic acid reductase from methotrexate-sensitive and -resistant human cell lines. Morandi, C., Attardi, G. J. Biol. Chem. (1981) [Pubmed]
  4. Expression of the plasmid-encoded type I dihydrofolate reductase gene in cultured mammalian cells: a novel selectable marker. Simonsen, C.S., Walter, M., Levinson, A.D. Nucleic Acids Res. (1988) [Pubmed]
  5. The nucleotide sequence of the cDNA coding for the human dihydrofolic acid reductase. Masters, J.N., Attardi, G. Gene (1983) [Pubmed]
  6. Folate induced-hypermotility response after bilateral injection into the nucleus accumbens of the rat. Possible mediation through dopaminergic mechanisms. Stephens, R.L., Uretsky, N.J. Neuropharmacology (1986) [Pubmed]
  7. Pneumocystis carinii dihydrofolate reductase used to screen potential antipneumocystis drugs. Broughton, M.C., Queener, S.F. Antimicrob. Agents Chemother. (1991) [Pubmed]
  8. Methotrexate assay by enzymatic inhibition, with use of centrifugal analyzer. Finley, P.R., Williams, R.J. Clin. Chem. (1977) [Pubmed]
  9. Effects of trimethoprim on leukaemic cells in vitro. Rivard, G.E., Momparler, L.F., Momparler, R.L. Br. J. Haematol. (1981) [Pubmed]
  10. Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand. Looareesuwan, S., Viravan, C., Webster, H.K., Kyle, D.E., Hutchinson, D.B., Canfield, C.J. Am. J. Trop. Med. Hyg. (1996) [Pubmed]
  11. Thymidylate synthetase and dihydrofolic acid reductase in the stimulated human lymphocyte. Haurani, F.I., Kardinal, C.G., Biermann, W.A. J. Cell. Physiol. (1978) [Pubmed]
  12. Methotrexate-resistant human promyelocytic leukemia (HL-60) cells express a dihydrofolate reductase with altered properties associated with increased enzyme activity. Dedhar, S., Goldie, J.H. Biochem. Biophys. Res. Commun. (1985) [Pubmed]
  13. On the structure of the cofactor in the complex formed with thymidylate synthetase, 5,10-methylenetetrahy-drofolate and 5-fluoro-2'-deoxyuridylate. Santi, D.V., Penã, V.A., Lam, S.S. Biochim. Biophys. Acta (1976) [Pubmed]
  14. Synergic convulsant effects of dihydrofolic and kainic acid after intracaudate infusion in rats. De Sarro, G.B., Rotiroti, D., Calo', M., Pujia, A., Anfosso, R., Nistico', G. Res. Commun. Chem. Pathol. Pharmacol. (1982) [Pubmed]
  15. Purification of dihydrofolate reductase from human leukocytes and from mouse liver and electrofocusing on thin-layer polyacrylamide gel. Schalhorn, A. Enzyme (1980) [Pubmed]
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