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Eaf2  -  ELL associated factor 2

Mus musculus

Synonyms: AW048865, ELL-associated factor 2, Ehrlich S-II transcriptional activator factor, FESTA-L, FESTA-S, ...
 
 
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Disease relevance of Eaf2

 

High impact information on Eaf2

 

Chemical compound and disease context of Eaf2

  • These observations suggest that U19 is growth inhibitory and tumor suppressive and that the disruption of androgen-dependent growth inhibition via U19 down-regulation is commonly associated with prostate cancer progression [1].
 

Biological context of Eaf2

  • Sikela; (2) Regional Differences in the Regulation of Brain Gene Expression: Relevance to the Detection of Genes Associated with Alcohol-Related Traits, by Robert Hitzemann; (3) Identification of Ethanol Quantitative Trait Loci Candidate Genes by Expression Profiling in Inbred Long Sleep/Inbred Short Sleep Congenic Mice, by Robnet T [4].
 

Anatomical context of Eaf2

  • These seminal neurodevelopmental issues have been examined using a series of clonally derived neural stem/progenitor cell lines established by retroviral transduction of embryonic (E16.5-E17.5) murine hippocampal and cerebellar cells using temperature-sensitive alleles (A58/U19) of the simian virus (SV) 40 large tumor (T) antigen [5].
 

Associations of Eaf2 with chemical compounds

 

Physical interactions of Eaf2

 

Regulatory relationships of Eaf2

  • Furthermore, deletion of the C-terminal tail of FESTA dramatically reduced its trans-activating ability and abolished its interaction with S-II [6].
 

Other interactions of Eaf2

  • FESTA is expressed specifically in kidney and spleen, supporting our notion that S-II participates in gene-specific regulation [6].
 

Analytical, diagnostic and therapeutic context of Eaf2

  • Expression of U19 in xenograft prostate tumors markedly induced apoptosis and inhibited tumor growth in vivo [1].

References

  1. Suppression of prostate tumor growth by U19, a novel testosterone-regulated apoptosis inducer. Xiao, W., Zhang, Q., Jiang, F., Pins, M., Kozlowski, J.M., Wang, Z. Cancer Res. (2003) [Pubmed]
  2. Experimental Mouse Lethality of Escherichia coli Isolates, in Relation to Accessory Traits, Phylogenetic Group, and Ecological Source. Johnson, J.R., Clermont, O., Menard, M., Kuskowski, M.A., Picard, B., Denamur, E. J. Infect. Dis. (2006) [Pubmed]
  3. Expression of murine ELL-associated factor 2 (Eaf2) is developmentally regulated. Li, M., Wu, X., Zhuang, F., Jiang, S., Jiang, M., Liu, Y.H. Dev. Dyn. (2003) [Pubmed]
  4. DNA microarray and proteomic strategies for understanding alcohol action. Sikela, J.M., Maclaren, E.J., Kim, Y., Karimpour-Fard, A., Cai, W.W., Pollack, J., Hitzemann, R., Belknap, J., McWeeney, S., Kerns, R.T., Downing, C., Johnson, T.E., Grant, K.J., Tabakoff, B., Hoffman, P., Wu, C.C., Miles, M.F. Alcohol. Clin. Exp. Res. (2006) [Pubmed]
  5. Generation and regulation of developing immortalized neural cell lines. Gökhan, S., Song, Q., Mehler, M.F. Methods (1998) [Pubmed]
  6. Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II. Saso, K., Ito, T., Natori, S., Sekimizu, K. J. Biochem. (2003) [Pubmed]
 
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