Disease relevance of Eaf2

• Consistent with its tumor-suppressive role, U19 down-regulation was observed in all of the surveyed prostate cancer cell lines and in 19 of 23 clinical human prostate tumor specimens [1].
• Experimental Mouse Lethality of Escherichia coli Isolates, in Relation to Accessory Traits, Phylogenetic Group, and Ecological Source [2].

High impact information on Eaf2

• Suppression of prostate tumor growth by U19, a novel testosterone-regulated apoptosis inducer [1].
• Overexpression of U19 in 12 surveyed cell lines induced apoptosis, and new protein synthesis is required for apoptosis induction [1].
• U19 is an evolutionarily conserved protein expressed in many human tissues, with the most abundant expression in the prostate, bone marrow, kidney, and lymph nodes [1].
• Loss of heterozygosity analysis revealed U19 allelic loss in 19 of the 23 specimens [1].
• During mouse embryogenesis, Eaf2 is preferentially expressed in the central nervous system and in sensory and neuroendocrine organs, including the brain, spinal cord, cranial and spinal ganglia, developing otocyst, the retina, and the pituitary [3].

Chemical compound and disease context of Eaf2

• These observations suggest that U19 is growth inhibitory and tumor suppressive and that the disruption of androgen-dependent growth inhibition via U19 down-regulation is commonly associated with prostate cancer progression [1].

Biological context of Eaf2

• Sikela; (2) Regional Differences in the Regulation of Brain Gene Expression: Relevance to the Detection of Genes Associated with Alcohol-Related Traits, by Robert Hitzemann; (3) Identification of Ethanol Quantitative Trait Loci Candidate Genes by Expression Profiling in Inbred Long Sleep/Inbred Short Sleep Congenic Mice, by Robnet T [4].

Anatomical context of Eaf2

• These seminal neurodevelopmental issues have been examined using a series of clonally derived neural stem/progenitor cell lines established by retroviral transduction of embryonic (E16.5-E17.5) murine hippocampal and cerebellar cells using temperature-sensitive alleles (A58/U19) of the simian virus (SV) 40 large tumor (T) antigen [5].

Associations of Eaf2 with chemical compounds

• FESTA contains a serine-rich region and a C-terminal tail that are highly similar to those of the ELL-associated factor EAF1 [6].

Physical interactions of Eaf2

• Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II [6].

Regulatory relationships of Eaf2

• Furthermore, deletion of the C-terminal tail of FESTA dramatically reduced its trans-activating ability and abolished its interaction with S-II [6].

Other interactions of Eaf2

• FESTA is expressed specifically in kidney and spleen, supporting our notion that S-II participates in gene-specific regulation [6].

Analytical, diagnostic and therapeutic context of Eaf2

• Expression of U19 in xenograft prostate tumors markedly induced apoptosis and inhibited tumor growth in vivo [1].

References