Gene Review:
NOXA1 - NADPH oxidase activator 1
Homo sapiens
Synonyms:
Antigen NY-CO-31, FLJ25475, NCF2-like protein, NOX activator 1, NY-CO-31, ...
- Loss of mcl-1 protein and inhibition of electron transport chain together induce anoxic cell death. Brunelle, J.K., Shroff, E.H., Perlman, H., Strasser, A., Moraes, C.T., Flavell, R.A., Danial, N.N., Keith, B., Thompson, C.B., Chandel, N.S. Mol. Cell. Biol. (2007)
- Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases. Ueyama, T., Geiszt, M., Leto, T.L. Mol. Cell. Biol. (2006)
- Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1. Miyano, K., Ueno, N., Takeya, R., Sumimoto, H. J. Biol. Chem. (2006)
- Noxa1 is a central component of the smooth muscle NADPH oxidase in mice. Ambasta, R.K., Schreiber, J.G., Janiszewski, M., Busse, R., Brandes, R.P. Free Radic. Biol. Med. (2006)
- Nox3 regulation by NOXO1, p47phox, and p67phox. Cheng, G., Ritsick, D., Lambeth, J.D. J. Biol. Chem. (2004)
- Bortezomib, but not cisplatin, induces mitochondria-dependent apoptosis accompanied by up-regulation of noxa in the non-small cell lung cancer cell line NCI-H460. Voortman, J., Checinska, A., Giaccone, G., Rodriguez, J.A., Kruyt, F.A. Mol. Cancer Ther. (2007)
- Nox1-dependent reactive oxygen generation is regulated by Rac1. Cheng, G., Diebold, B.A., Hughes, Y., Lambeth, J.D. J. Biol. Chem. (2006)