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Gene Review

NOXA1  -  NADPH oxidase activator 1

Homo sapiens

Synonyms: Antigen NY-CO-31, FLJ25475, NCF2-like protein, NOX activator 1, NY-CO-31, ...
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High impact information on NOXA1

  • The individual loss of Bim, Bid, Puma, Noxa, Bad, caspase-2, or hypoxia-inducible factor 1beta, which are potential upstream regulators of Bax or Bak, did not prevent anoxia-induced cell death [1].
  • However, membrane targeting of Noxa1 is not sufficient for activation of Nox1 [2].
  • Plasma membrane targeting of Noxa1 depends on Noxo1, through tail-to-tail interactions between these proteins [2].
  • Superoxide production in Nox1-expressing HeLa and Caco-2 cells is decreased by depletion or sequestration of Rac; on the other hand, it is enhanced by expression of the constitutively active Rac1(Q61L), but not by that of a mutant Rac1 with the A27K substitution, deficient in binding to Noxa1 [3].
  • Noxa1 is a central component of the smooth muscle NADPH oxidase in mice [4].

Biological context of NOXA1


Anatomical context of NOXA1


Associations of NOXA1 with chemical compounds

  • This was associated with a marked increase in levels of the BH3-only proapoptotic protein Noxa and the antiapoptotic protein Mcl-1 [6].

Regulatory relationships of NOXA1

  • Rac1(G12V) interaction with NOXA1 was enhanced by Nox1 and NOXO1, suggesting cooperative binding [7].

Other interactions of NOXA1


  1. Loss of mcl-1 protein and inhibition of electron transport chain together induce anoxic cell death. Brunelle, J.K., Shroff, E.H., Perlman, H., Strasser, A., Moraes, C.T., Flavell, R.A., Danial, N.N., Keith, B., Thompson, C.B., Chandel, N.S. Mol. Cell. Biol. (2007) [Pubmed]
  2. Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases. Ueyama, T., Geiszt, M., Leto, T.L. Mol. Cell. Biol. (2006) [Pubmed]
  3. Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1. Miyano, K., Ueno, N., Takeya, R., Sumimoto, H. J. Biol. Chem. (2006) [Pubmed]
  4. Noxa1 is a central component of the smooth muscle NADPH oxidase in mice. Ambasta, R.K., Schreiber, J.G., Janiszewski, M., Busse, R., Brandes, R.P. Free Radic. Biol. Med. (2006) [Pubmed]
  5. Nox3 regulation by NOXO1, p47phox, and p67phox. Cheng, G., Ritsick, D., Lambeth, J.D. J. Biol. Chem. (2004) [Pubmed]
  6. Bortezomib, but not cisplatin, induces mitochondria-dependent apoptosis accompanied by up-regulation of noxa in the non-small cell lung cancer cell line NCI-H460. Voortman, J., Checinska, A., Giaccone, G., Rodriguez, J.A., Kruyt, F.A. Mol. Cancer Ther. (2007) [Pubmed]
  7. Nox1-dependent reactive oxygen generation is regulated by Rac1. Cheng, G., Diebold, B.A., Hughes, Y., Lambeth, J.D. J. Biol. Chem. (2006) [Pubmed]
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