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Gene Review

Noxa1  -  NADPH oxidase activator 1

Mus musculus

Synonyms: NY-CO-31, SDCCAG31
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High impact information on Noxa1

  • Mouse embryonic fibroblasts deficient in Noxa [Noxa(-/-) mouse embryonic fibroblasts (MEFs)] showed notable resistance to oncogene-dependent apoptosis in response to DNA damage, which was further increased by introducing an additional null zygosity for Bax [1].
  • Noxa(-/-) mice showed resistance to X-ray irradiation-induced gastrointestinal death, accompanied with impaired apoptosis of the epithelial cells of small intestinal crypts, indicating the contribution of Noxa to the p53 response in vivo [1].
  • To assess the in vivo relevance of these findings, we subjected mice lacking Puma, Noxa, or Bim to whole-body gamma-radiation or the glucocorticoid dexamethasone and compared lymphocyte survival with that in wild-type and BCL2-transgenic mice [2].
  • p53 triggers apoptosis in oncogene-expressing fibroblasts by the induction of Noxa and mitochondrial Bax translocation [3].
  • The co-expression of Brn-3a and p53 results in decreased endogenous Noxa protein in the neuronal cell line, ND7, suggesting a direct functional effect of this interaction [4].

Biological context of Noxa1


Anatomical context of Noxa1


Other interactions of Noxa1


Analytical, diagnostic and therapeutic context of Noxa1

  • We studied the role of Noxa, one of the transcriptional targets of p53 that encodes a proapoptotic protein of the Bcl-2 family, by the gene-targeting approach [1].
  • Furthermore, among the BH3-only protein members examined, Noxa exhibited the most marked upregulation after axotomy in the mouse [8].


  1. Integral role of Noxa in p53-mediated apoptotic response. Shibue, T., Takeda, K., Oda, E., Tanaka, H., Murasawa, H., Takaoka, A., Morishita, Y., Akira, S., Taniguchi, T., Tanaka, N. Genes Dev. (2003) [Pubmed]
  2. BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo. Erlacher, M., Michalak, E.M., Kelly, P.N., Labi, V., Niederegger, H., Coultas, L., Adams, J.M., Strasser, A., Villunger, A. Blood (2005) [Pubmed]
  3. p53 triggers apoptosis in oncogene-expressing fibroblasts by the induction of Noxa and mitochondrial Bax translocation. Schuler, M., Maurer, U., Goldstein, J.C., Breitenbücher, F., Hoffarth, S., Waterhouse, N.J., Green, D.R. Cell Death Differ. (2003) [Pubmed]
  4. Brn-3a transcription factor blocks p53-mediated activation of proapoptotic target genes Noxa and Bax in vitro and in vivo to determine cell fate. Hudson, C.D., Morris, P.J., Latchman, D.S., Budhram-Mahadeo, V.S. J. Biol. Chem. (2005) [Pubmed]
  5. Noxa1 is a central component of the smooth muscle NADPH oxidase in mice. Ambasta, R.K., Schreiber, J.G., Janiszewski, M., Busse, R., Brandes, R.P. Free Radic. Biol. Med. (2006) [Pubmed]
  6. BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death. Akhtar, R.S., Geng, Y., Klocke, B.J., Latham, C.B., Villunger, A., Michalak, E.M., Strasser, A., Carroll, S.L., Roth, K.A. J. Neurosci. (2006) [Pubmed]
  7. p53 activation domain 1 is essential for PUMA upregulation and p53-mediated neuronal cell death. Cregan, S.P., Arbour, N.A., Maclaurin, J.G., Callaghan, S.M., Fortin, A., Cheung, E.C., Guberman, D.S., Park, D.S., Slack, R.S. J. Neurosci. (2004) [Pubmed]
  8. Noxa is a critical mediator of p53-dependent motor neuron death after nerve injury in adult mouse. Kiryu-Seo, S., Hirayama, T., Kato, R., Kiyama, H. J. Neurosci. (2005) [Pubmed]
  9. Nox is playing with a full deck in vascular smooth muscle, a commentary on "Noxa1 is a central component of the smooth muscle NADPH oxidase in mice". Lassègue, B., Griendling, K.K. Free Radic. Biol. Med. (2006) [Pubmed]
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