Disease relevance of CGB

• We aimed to compare the expression of individual CGB genes during normal pregnancy and in cases of recurrent miscarriage (RM) and ectopic pregnancy (EP) [1].
• In conclusion, DNA copy number profiles were generated by CGH for most of the publicly available breast cancer cell lines and were made available on a web site (http://www.nhgri.nih.gov/DIR/CGB/++ +CR2000) [2].

High impact information on CGB

• Two MCCB missense mutations and one splicing defect mutation leading to early MCC beta truncation were found in CGB patients [3].
• The LHB/CGB cluster consists of seven duplicated genes critical in human reproduction [4].
• Overexpression of the CGA gene was not accompanied by overexpression of the CGB gene [5].
• PstI RFLP of the CGB gene [6].
• The addition of EGF decreases CGB secretion and prolongs production for up to 13 days [7].

Biological context of CGB

• The luteinizing hormone (LHB)/chorionic gonadotropin (CGB) gene cluster in humans contains a candidate example of this process [8].
• In the LHB/CGB region, high sequence diversity, concentration of gene-conversion acceptor sites, and strong LD colocalize with peripheral genes, whereas central loci are characterized by lower variation, gene-conversion donor activity, and breakdown of LD between close markers [4].
• (3) CF patients with low liver function had significantly lower protein binding of aldosterone and only slightly lower CGB capacity, presumably due to disturbed protein synthesis by the liver [9].

Anatomical context of CGB

• N-terminal peptides of chromogranin A and B (CGA and CGB) were compared for dilator responses in isolated bovine coronary arteries (bCoA), measuring diameter changes as a function of pressure. bCoA developed and maintained myogenic tone (MYT) at approximately 20% from 50 to 150 mm Hg [10].
• A 3H-cortisol-binding assay, which distinguished between CBG and glucocorticoid receptor, was used to determine CGB levels in the serum and in the cytosol, nuclear, and membrane fractions of deciduoma, myometrium, liver, kidney, muscle, and small intestine [11].
• In contrast to the regulation of the enkephalin system, no increase in either CGA or CGB mRNA or gene transcription attended depolarization-induced secretion from chromaffin cells [12].

Associations of CGB with chemical compounds

• When added to villous explant cultures, EGF did nothing to the pattern of CGB secretion, but addition of SB203580 prevented the normal surge in secretion during syncytial regeneration over Days 3-7 [7].
• Utilization of glycine was the most frequent atypical variable; 36 of 276 (13%) A/D isolates utilized glycine while being inhibited by either GCP or CGB or both [13].
• Three hundred twenty-three clinical isolates of Cryptococcus neoformans of diverse geographic origins were biochemically serogrouped using glycine-cycloheximide-phenol red agar (GCP), the same medium less cycloheximide (GOP), and glycine-L-canavanine bromothymol blue agar (CGB) [13].
• The results disclosed a high sensitivity, D-proline 99-13% and CGB 99.57%, for screening of the varieties [14].

Other interactions of CGB

• We have tested this hypothesis by quantifying the expression of the hCG beta (CGB) RNA, LHCGR RNA and LHCGR proteins in chorionic villous samples [15].

References