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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Deciduoma

  • MPA treatment was found to induce uterine secretory changes, glandular cystic hyperplasia, and eventually deciduomas that stained strongly for desmin and to a lesser degree for vimentin, suggesting a muscular differentiation [1].

High impact information on Deciduoma

  • Increased concentrations of apoptotic cells were observed at the periphery of the growing deciduoma and in the antimesometrial deciduoma near the luminal epithelium after both treatments [2].
  • In vitro, murine decidual cells derived from artificially induced deciduomas could be induced to produce the Isg15 protein as well as Isg15-conjugated proteins when stimulated with type 1 IFN, though were less responsive to IFN-gamma [3].
  • Furthermore, our observations support the hypothesis that the expression of IGFBP-1, a protein capable of inhibiting the mitogenic activity of IGF-I, in deciduoma tissue may inhibit paracrine IGF-1 actin and allow for the differentiation of stromal tissue [4].
  • Mechanical separation of the deciduoma tissue from the underlying myometrium revealed that the deciduoma tissue was depleted in IGF-I mRNA, while the majority of the IGFBP-1 was located in the deciduoma tissue [4].
  • This strongly suggests a close relationship between the loss of PR and the regression of the deciduoma [5].

Biological context of Deciduoma


Anatomical context of Deciduoma

  • These results suggest that mast cells are not essential for formation of deciduomata and that histamine originating from sources other than mast cells may be important in deciduoma formation [8].
  • However, the decidual expression of cyclin D3 mRNA was not dependent on the presence of blastocysts, since increased expression also occurred in experimentally induced deciduoma in the absence of blastocysts [9].
  • The results suggest that the factors synthetised by decidua or deciduoma are the same and are not induced by exposure to foreign histocompatibility antigens of the fetus [10].
  • Expression of parathyroid hormone-related protein (PTHrP) and the PTH/PTHrP receptor in the rat uterus during early pregnancy and following artificial deciduoma induction [11].
  • 6. These results indicate that, in the endometrium, the iNOS/endogenous nitric oxide system may be linked to the biochemical and metabolic mechanisms responsible for the developmental responsiveness of the deciduoma to dexamethasone exposure [12].

Associations of Deciduoma with chemical compounds


Gene context of Deciduoma

  • Consistent with angiogenesis in general during decidualization, we believe EDG1 and EDG5 to be regulated by the embryo because no microvascular expression for these receptors was observed in oil-induced deciduomas [16].
  • Maternal TIMP-3 expression also occurred in the absence of embryonic MMP-9 expression in decidual reactions induced by parthenogenetic embryos (where MMP-9 positive cells were not detected) or in oil-induced deciduomas [17].
  • In contrast, MT-III and MT-IV mRNAs were both abundant in the maternal deciduum, and in experimentally induced deciduoma on 7 and 8 days postcoitum (1 dpc = vaginal plug), as are MT-I and -II mRNAs [18].
  • Severe trauma, such as crushing of the uterine tissue, has previously been shown to remove the requirement for nidatory estradiol for deciduomas to develop, indicating that the greater susceptibility of alphaERKO uterine tissue to damage from intraluminal oil infusion is contributing to decidualization in the absence of ERalpha [19].
  • Although the artificially-induced deciduoma weights and number of implantation sites were similar between stathmin-knockout (KO) and wild-type (WT) mice, the stathmin-KO mice had fewer newborn pups (reduced by 30%) [20].

Analytical, diagnostic and therapeutic context of Deciduoma

  • Northern blot analysis demonstrated TGF-alpha mRNA expression specifically in the deciduoma beginning on the day of decidual stimulus (Day 4), increasing on Day 6, and continuing through Day 14 [21].
  • With respect to progestomimetic activity in vivo, trimegestone was more potent than reference progestins in the endometrial transformation test in the rabbit, preventing the uterotrophic effect of estradiol in the immature mouse bioassay, and had more effect on traumatic deciduoma formation and greater oral antiovulatory activity in the rat [22].


  1. Mouse mammary tumors induced by medroxyprogesterone acetate: immunohistochemistry and hormonal receptors. Molinolo, A.A., Lanari, C., Charreau, E.H., Sanjuan, N., Pasqualini, C.D. J. Natl. Cancer Inst. (1987) [Pubmed]
  2. Progesterone withdrawal and RU-486 treatment stimulate apoptosis in specific uterine decidual cells. Moulton, B.C., Motz, J., Serdoncillo, C., Akcali, K.C., Khan, S.A. Cell Death Differ. (1997) [Pubmed]
  3. Interferon-stimulated gene-15 (Isg15) expression is up-regulated in the mouse uterus in response to the implanting conceptus. Austin, K.J., Bany, B.M., Belden, E.L., Rempel, L.A., Cross, J.C., Hansen, T.R. Endocrinology (2003) [Pubmed]
  4. Expression of insulin-like growth factor-I and insulin-like growth factor-binding protein-1 in the rat uterus during decidualization. Croze, F., Kennedy, T.G., Schroedter, I.C., Friesen, H.G., Murphy, L.J. Endocrinology (1990) [Pubmed]
  5. Deciduomal estrogen and progesterone receptors in unilateral pregnant hamsters. Chen, T.J., Hwang, T.C., Huang, C.C., Jow, G.M., Yu, J.Y. Endocrinology (1989) [Pubmed]
  6. Progesterone and estrogen control of uterine prostaglandin dehydrogenase activity during deciduomal growth. Alam, N.A., Russell, P.T., Tabor, M.W., Moulton, B.C. Endocrinology (1976) [Pubmed]
  7. Lipid peroxidation in the rat uterus during deciduoma induced cell differentiation. Devasagayam, T.P., Sivabalan, R., Tarachand, U. Biochem. Int. (1990) [Pubmed]
  8. Deciduoma formation in uterus of genetically mast cell-deficient W/Wv mice. Hatanaka, K., Kitamura, Y., Maeyama, K., Watanabe, T., Matsumoto, K. Biol. Reprod. (1982) [Pubmed]
  9. Cyclin D3 in the mouse uterus is associated with the decidualization process during early pregnancy. Das, S.K., Lim, H., Paria, B.C., Dey, S.K. J. Mol. Endocrinol. (1999) [Pubmed]
  10. Comparative study of biological properties of proteins synthetised in vitro by murine decidua and deciduoma. Dearden-Badet, M.T. American journal of reproductive immunology and microbiology : AJRIM. (1986) [Pubmed]
  11. Expression of parathyroid hormone-related protein (PTHrP) and the PTH/PTHrP receptor in the rat uterus during early pregnancy and following artificial deciduoma induction. Tucci, J., Beck, F. J. Reprod. Fertil. (1998) [Pubmed]
  12. Dexamethasone-induced changes in endometrial growth and inducible nitric oxide synthase during decidualization in rats. Spencer, F., Chi, L., Zhu, M.X. Clin. Exp. Pharmacol. Physiol. (1998) [Pubmed]
  13. Inhibitory effects of aminoglutethimide and isoxazole on progesterone production and deciduoma formation in rats. Inaba, T., Wiest, W.G. Endocrinology (1980) [Pubmed]
  14. Estrogen and progesterone receptors in the endometrium, myometrium, and metrial gland of the rat during the decidualization process. Martel, D., Monier, M.N., Psychoyos, A., DeFeo, V.J. Endocrinology (1984) [Pubmed]
  15. Presence of urokinase plasminogen activator and plasminogen activator inhibitor-1 messenger ribonucleic acids in rat endometrium during decidualization in vivo. Wang, S., Kennedy, T.G., Zhang, X. Biol. Reprod. (1996) [Pubmed]
  16. Sphingosine-1-phosphate receptor expression and signaling correlate with uterine prostaglandin-endoperoxide synthase 2 expression and angiogenesis during early pregnancy. Skaznik-Wikiel, M.E., Kaneko-Tarui, T., Kashiwagi, A., Pru, J.K. Biol. Reprod. (2006) [Pubmed]
  17. Tissue inhibitor of metalloproteinases-3 is the major metalloproteinase inhibitor in the decidualizing murine uterus. Leco, K.J., Edwards, D.R., Schultz, G.A. Mol. Reprod. Dev. (1996) [Pubmed]
  18. Activation of the complete mouse metallothionein gene locus in the maternal deciduum. Liang, L., Fu, K., Lee, D.K., Sobieski, R.J., Dalton, T., Andrews, G.K. Mol. Reprod. Dev. (1996) [Pubmed]
  19. Studies using the estrogen receptor alpha knockout uterus demonstrate that implantation but not decidualization-associated signaling is estrogen dependent. Curtis Hewitt, S., Goulding, E.H., Eddy, E.M., Korach, K.S. Biol. Reprod. (2002) [Pubmed]
  20. Expression of stathmin family genes in the murine uterus during early pregnancy. Yoshie, M., Tamura, K., Hara, T., Kogo, H. Mol. Reprod. Dev. (2006) [Pubmed]
  21. Induction of transforming growth factor-alpha gene expression in rat decidua is independent of the conceptus. Bonvissuto, A.C., Lala, P.K., Kennedy, T.G., Nygard, K., Lee, D.C., Han, V.K. Biol. Reprod. (1992) [Pubmed]
  22. The pharmacological profile of a novel norpregnance progestin (trimegestone). Philibert, D., Bouchoux, F., Degryse, M., Lecaque, D., Petit, F., Gaillard, M. Gynecol. Endocrinol. (1999) [Pubmed]
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