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Chemical Compound Review

Vermella     4-bromo-5-methyl-2-propan-2- yl-phenol

Synonyms: Killvermyl, Bromothymol, PubChem19801, SureCN22487, ZINC00001059, ...
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Disease relevance of Killvermyl


High impact information on Killvermyl

  • D-Sorbitol, as the main carbon source, differentiates the species that can ferment it by the pH indicators cresol red and bromothymol blue [4].
  • For primary isolation on genital mycoplasma agar 95% N2-5% CO2 gave 100% correlation with growth in bromothymol blue broth, whereas certain strains failed to grow on agar incubated in air, the TABCO2 system (Lab-Tek Division, Miles Laboratories, Ltd., Rexdale, Canada), 100% CO2, or under anaerobiosis [5].
  • The difference in pH of the sample in the presence and absence of formaldehyde, which blocks the amino function, provides the value of r.a.n. by monitoring the changes in absorbance of bromothymol blue at 616 nm [6].
  • 1. During aerobic cation uptake in liver mitochondria, the hydrophobic pH indicator bromothymol blue undergoes a multiphase response: phase 1 (rapid acidification), phase 2 (slow alkalinization), phase 3 (rapid alkalinization) and phase 4 (reacidification) [7].
  • The change in pH was demonstrated by spectral changes of the pH indicators Bromocresol Green, Bromothymol Blue, Bromocresol Purple and Phenol Red. The magnitude of the pH change was calculated from the kinetics of the changes in the indicators' absorbance and from fluorescence intensity of naphtholate [8].

Chemical compound and disease context of Killvermyl

  • A synthetic basal salts medium containing inositol as the sole source for carbon and energy and bromothymol blue as pH indicator, selectively supports the growth of Klebsiella pneumoniae and Serratia spp [9].

Anatomical context of Killvermyl


Associations of Killvermyl with other chemical compounds


Analytical, diagnostic and therapeutic context of Killvermyl

  • The drug was determined with bromothymol blue at pH 9.0, using one extraction in the direct procedure and 2 successive extractions in the combined elution-extraction process after thin layer chromatography [17].


  1. Bromothymol blue broth: improved medium for detection of Ureaplasma urealyticum (T-strain mycoplasma). Robertson, J.A. J. Clin. Microbiol. (1978) [Pubmed]
  2. Dye-containing buffered charcoal-yeast extract medium for differentiation of members of the family Legionellaceae. Vickers, R.M., Brown, A., Garrity, G.M. J. Clin. Microbiol. (1981) [Pubmed]
  3. Detection of bovine mastitis by bromothymol blue pH indicator test. Marschke, R.J., Kitchen, B.J. J. Dairy Sci. (1985) [Pubmed]
  4. Identification of Vibrio proteolyticus with a differential medium and a specific probe. Muniesa-Pérez, M., Jofre, J., Blanch, A.R. Appl. Environ. Microbiol. (1996) [Pubmed]
  5. Effect of gaseous conditions on isolation and growth of Ureaplasma urealyticum on agar. Robertson, J.A. J. Clin. Microbiol. (1982) [Pubmed]
  6. Flow injection determination of readily assimilable nitrogen compounds during vinification. González-Rodriguez, J., Pérez-Juan, P., Luque de Castro, M.D. The Analyst. (2002) [Pubmed]
  7. Tracking of proton flow during transition from anaerobiosis to steady state. 2. Effect of cation uptake on the response of a hydrophobic membrane bound pH indicator. Luvisetto, S., Cola, C., Schmehl, I., Azzone, G.F. Eur. J. Biochem. (1991) [Pubmed]
  8. Rapid pH and deltamuH+ jump by short laser pulse. Gutman, M., Huppert, D. J. Biochem. Biophys. Methods (1979) [Pubmed]
  9. Inositol as a selective substrate for the growth of Klebsiellae and Serratiae. Legakis, N.J., Papavassiliou, J.T., Xilinas, M.E. Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie. (1976) [Pubmed]
  10. About some common biochemical and pharmacological properties of bile salts and non steroidal anti-inflammatory drugs. Famaey, J.P., Whitehouse, M.W. Arch. Int. Physiol. Biochim. (1978) [Pubmed]
  11. Bromothymol blue as a probe for structural changes of model membranes induced by hemoglobin. Gorbenko, G.P. Biochim. Biophys. Acta (1998) [Pubmed]
  12. The inhibition by bromothymol blue of anion translocation across the mitochondrial membrane. Aleksandrowicz, Z., Sweirczyński, J. Biochim. Biophys. Acta (1975) [Pubmed]
  13. Electron microscopical study of the structure of liposome-type artificial red blood cells stabilized with carboxymethylchitin. Wehrli, E., Kondo, T., Kato, A., Izawa, H., Kreuter, J. Journal of microencapsulation. (1984) [Pubmed]
  14. Can we improve the diagnosis of rupture of membranes? The value of insulin-like growth factor binding protein-1. Martinez de Tejada, B., Boulvain, M., Dumps, P., Bischof, P., Meisser, A., Irion, O. BJOG : an international journal of obstetrics and gynaecology. (2006) [Pubmed]
  15. Studies on the carboxymethyl chitosan-containing liposomes for their stability and controlled release of dapsone. Alamelu, S., Rao, K.P. Journal of microencapsulation. (1991) [Pubmed]
  16. Differentiation of Cryptococcus neoformans serotypes A and D using creatinine dextrose bromothymol blue thymine medium. Irokanulo, E.A., Akueshi, C.O., Makinde, A.A. Br. J. Biomed. Sci. (1994) [Pubmed]
  17. Ion-pair extraction method for quantitation of a bisquaternary ammonium compound, pancuronium bromide. Michoel, A.J., Kinget, R.D. Journal - Association of Official Analytical Chemists. (1976) [Pubmed]
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