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Gene Review

RAB32  -  RAB32, member RAS oncogene family

Homo sapiens

Synonyms: Ras-related protein Rab-32
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Disease relevance of RAB32

  • Northern blots for Rab31 and Rab32 identified 4.4 kb and 1.35 kb mRNA species, respectively, in some human tissues and in human erythroleukemia (HEL) cells [1].
  • HPP1 and RAB32 methylation was independent of MSI status and was observed in 4 of 59 and 0 of 64 nondysplastic mucosae, 20 of 38 and 1 of 25 dysplasias, and 28 of 61 and 20 of 60 carcinomas, respectively [2].
  • Initial screening of six genes in 57 primary colon cancers detected the following gene with MSI-H cancer-specific hypermethylation: RAB32, a ras family member and A-kinase-anchoring protein, was methylated in 14 of 25 (56%) MSI-H cancers but in none of 32 non-MSI-H cancers or 23 normal colonic specimens [3].
  • We sought to determine the prevalence of RAB32 hypermethylation in gastric and endometrial adenocarcinomas, the 2 other major tumor types in which MSI-H is common [4].
  • Thirteen (27%) of 48 gastric cancers demonstrated evidence of RAB32 hypermethylation [4].

High impact information on RAB32

  • Furthermore, HPP1 methylation occurs early, in 7% of nondysplastic and approximately half of dysplastic mucosae, whereas RAB32 methylation occurs at the transition to invasive growth, being rarer in dysplasias [2].
  • This work identifies a key role for the Rab38/Rab32 subfamily of Rab proteins in the biogenesis of melanosomes and potentially other lysosome-related organelles [5].
  • We report that cht Rab38(G19V) is inactive and that the nearly normal pigmentation in cht melanocytes results from functional compensation by the closely related Rab32 [5].
  • Transient transfection of a GTP binding-deficient mutant of Rab32 promotes aberrant accumulation of mitochondria at the microtubule organizing center [6].
  • RAB32 hypermethylation correlated with RAB32 mRNA down-regulation and with hMLH1 hypermethylation [3].

Biological context of RAB32


Anatomical context of RAB32

  • Subcellular fractionation and immunofluorescent approaches indicate that Rab32 and a proportion of the cellular PKA pool are associated with mitochondria [6].

Associations of RAB32 with chemical compounds

  • Binding of [(35)S]GTP[S] was optimal with 5 microm Mg(2+)(free) and was markedly inhibited by higher Mg(2+) concentrations in the case of GST-Rab31 but not GST-Rab32 [1].

Analytical, diagnostic and therapeutic context of RAB32


  1. Molecular cloning, bacterial expression and properties of Rab31 and Rab32. Bao, X., Faris, A.E., Jang, E.K., Haslam, R.J. Eur. J. Biochem. (2002) [Pubmed]
  2. Molecular phenotype of inflammatory bowel disease-associated neoplasms with microsatellite instability. Schulmann, K., Mori, Y., Croog, V., Yin, J., Olaru, A., Sterian, A., Sato, F., Wang, S., Xu, Y., Deacu, E., Berki, A.T., Hamilton, J.P., Kan, T., Abraham, J.M., Schmiegel, W., Harpaz, N., Meltzer, S.J. Gastroenterology (2005) [Pubmed]
  3. Identification of genes uniquely involved in frequent microsatellite instability colon carcinogenesis by expression profiling combined with epigenetic scanning. Mori, Y., Yin, J., Sato, F., Sterian, A., Simms, L.A., Selaru, F.M., Schulmann, K., Xu, Y., Olaru, A., Wang, S., Deacu, E., Abraham, J.M., Young, J., Leggett, B.A., Meltzer, S.J. Cancer Res. (2004) [Pubmed]
  4. RAB32 hypermethylation and microsatellite instability in gastric and endometrial adenocarcinomas. Shibata, D., Mori, Y., Cai, K., Zhang, L., Yin, J., Elahi, A., Hamelin, R., Wong, Y.F., Lo, W.K., Chung, T.K., Sato, F., Karpeh, M.S., Meltzer, S.J. Int. J. Cancer (2006) [Pubmed]
  5. Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes. Wasmeier, C., Romao, M., Plowright, L., Bennett, D.C., Raposo, G., Seabra, M.C. J. Cell Biol. (2006) [Pubmed]
  6. Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics. Alto, N.M., Soderling, J., Scott, J.D. J. Cell Biol. (2002) [Pubmed]
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