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Gene Review

TRIOBP  -  TRIO and F-actin binding protein

Homo sapiens

Synonyms: DFNB28, HRIHFB2122, KIAA1662, Protein Tara, TAP68, ...
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Disease relevance of TRIOBP

  • 1. We report here that mutations in a novel 218-kDa isoform of TRIOBP (TRIO and filamentous actin [F-actin] binding protein) are associated with DFNB28 hearing loss in a total of nine Palestinian families [1].
  • Use of TARA hemiarthroplasty in advanced osteonecrosis [2].
  • In this symmetrical double-blind study, triamcinolone acetonide (TA) cream 0.1% and a cream containing TA 0.1% plus RA 0.025% (TARA) were compared in 18 subjects with eczema [3].
  • Ethanol extracts of the aerial parts of six Hypericum species, H. barbatum, H. androsaemum, H. richerii, H. hirsutum, H. perforatum and H. perforatum cultivated on mountain Tara were tested for antiinflammatory activity in comparison with indomethacin (IND) using the carrageenan-induced rat paw edema test [4].

High impact information on TRIOBP

  • In seven families, six different mutant alleles of TRIOBP on chromosome 22q13 cosegregate with autosomal recessive nonsyndromic deafness [5].
  • Mutations in a novel isoform of TRIOBP that encodes a filamentous-actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss [1].
  • The novel long isoform of TRIOBP has a restricted expression profile, including cochlea, retina, and fetal brain, whereas the original short isoform is widely expressed [1].
  • Antibodies to TRIOBP reveal expression in sensory cells of the inner ear and colocalization with F-actin along the length of the stereocilia [1].
  • Tara stabilizes F-actin structures as indicated by the relative resistance of Tara-expressing cells to the F-actin destabilizer Latrunculin B [6].

Biological context of TRIOBP

  • In both tailings types, the fertilized plants showed significantly increased total biomass production, but the plants grew greater biomass in Tara tailings relative to Silvermines tailings even without fertilization [7].

Anatomical context of TRIOBP

  • Cells that transiently or stably overexpress Tara display an extensively flattened cell morphology with enhanced stress fibers and cortical F-actin [6].

Associations of TRIOBP with chemical compounds

  • A procedure for the extraction and capillary zone electrophoresis (CZE) separation of proteins from carob, guar and tara gums in a background electrolyte (BGE) of pH 9 containing 0.1% polyvinyl alcohol is described [8].
  • Bearer; and (3) Ethanol and Axon Guidance, by Tara A [9].
  • Cultures enriched with the effluent or Tara tannin were able to degrade tannic acid [10].
  • Using PLM with toluidine blue and iodine staining techniques, unadulterated locust bean gum samples were distinguished from mixed samples through the differential staining of components in locust bean versus guar and tara gums [11].

Other interactions of TRIOBP

  • Herein we characterize a novel Trio-binding protein, Tara, that is comprised of an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region [6].

Analytical, diagnostic and therapeutic context of TRIOBP

  • Trio and Tara associate as assessed by the yeast interaction-trap assays and mammalian co-immunoprecipitation studies [6].
  • Purification of galactomannans including guaran, tara gum, and locust bean gum is described as well as their use as a sieving matrix in DNA sequencing by capillary electrophoresis (CE) [12].
  • Total articular resurfacing arthroplasty with the Tara device was performed on sixty-seven hips in sixty-three patients from 1978 to 1981 [13].
  • A clinical, radiological and biomechanical study of the TARA hip prosthesis [14].


  1. Mutations in a novel isoform of TRIOBP that encodes a filamentous-actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss. Shahin, H., Walsh, T., Sobe, T., Abu Sa'ed, J., Abu Rayan, A., Lynch, E.D., Lee, M.K., Avraham, K.B., King, M.C., Kanaan, M. Am. J. Hum. Genet. (2006) [Pubmed]
  2. Use of TARA hemiarthroplasty in advanced osteonecrosis. Scott, R.D., Urse, J.S., Schmidt, R., Bierbaum, B.E. The Journal of arthroplasty. (1987) [Pubmed]
  3. Treatment of eczema with a mixture of triamcinolone acetonide and retinoic acid: a double-blind study. Schmied, C., Piletta, P.A., Saurat, J.H. Dermatology (Basel) (1993) [Pubmed]
  4. Antiinflammatory activity of ethanol extracts of Hypericum perforatum L., H. barbatum Jacq., H. hirsutum L., H. richeri Vill. and H. androsaemum L. in rats. Savikin, K., Dobrić, S., Tadić, V., Zdunić, G. Phytotherapy research : PTR (2007) [Pubmed]
  5. Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are associated with nonsyndromic recessive deafness. Riazuddin, S., Khan, S.N., Ahmed, Z.M., Ghosh, M., Caution, K., Nazli, S., Kabra, M., Zafar, A.U., Chen, K., Naz, S., Antonellis, A., Pavan, W.J., Green, E.D., Wilcox, E.R., Friedman, P.L., Morell, R.J., Riazuddin, S., Friedman, T.B. Am. J. Hum. Genet. (2006) [Pubmed]
  6. Tara, a novel F-actin binding protein, associates with the Trio guanine nucleotide exchange factor and regulates actin cytoskeletal organization. Seipel, K., O'Brien, S.P., Iannotti, E., Medley, Q.G., Streuli, M. J. Cell. Sci. (2001) [Pubmed]
  7. Influence of Typha latifolia and fertilization on metal mobility in two different Pb-Zn mine tailings types. Jacob, D.L., Otte, M.L. Sci. Total Environ. (2004) [Pubmed]
  8. Identification of Leguminosae gums and evaluation of carob-guar mixtures by capillary zone electrophoresis of protein extracts. Ruiz-Angel, M.J., Simó-Alfonso, E.F., Mongay-Fernández, C., Ramis-Ramos, G. Electrophoresis (2002) [Pubmed]
  9. Signaling pathways regulating cell motility: a role in ethanol teratogenicity? Lindsley, T.A., Miller, M.W., Littner, Y., Bearer, C.F. Alcohol. Clin. Exp. Res. (2006) [Pubmed]
  10. Isolation and characterization of polymeric galloyl-ester-degrading bacteria from a tannery discharge place. Franco, A.R., Calheiros, C.S., Pacheco, C.C., De Marco, P., Manaia, C.M., Castro, P.M. Microb. Ecol. (2005) [Pubmed]
  11. Detection of adulteration of locust bean gum with guar gum by capillary electrophoresis and polarized light microscopy. Flurer, C.L., Crowe, J.B., Wolnik, K.A. Food additives and contaminants. (2000) [Pubmed]
  12. Galactomannans as a sieving matrix in capillary electrophoresis. Dolník, V., Gurske, W.A., Padua, A. Electrophoresis (2001) [Pubmed]
  13. Total articular resurfacing arthroplasty. Analysis of component failure in sixty-seven hips. Head, W.C. The Journal of bone and joint surgery. American volume. (1984) [Pubmed]
  14. A clinical, radiological and biomechanical study of the TARA hip prosthesis. de Waal Malefijt, M.C., Huiskes, R. Archives of orthopaedic and trauma surgery. (1993) [Pubmed]
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