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MeSH Review


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Disease relevance of Osteonecrosis


Psychiatry related information on Osteonecrosis


High impact information on Osteonecrosis


Chemical compound and disease context of Osteonecrosis

  • OBJECTIVE: To investigate the effects of combination treatment with an anticoagulant (warfarin) plus a lipid-lowering agent (probucol) on the prevention of steroid-induced osteonecrosis (ON) in rabbits [11].
  • Enzyme activity, which was inhibited by EDTA, was greater in extracts of fibrillated osteoarthritic cartilage than in extracts of grossly normal cartilage from the same joint or in extracts of cartilage from joints with osteonecrosis [12].
  • Zoledronic acid treatment results in retention of femoral head structure after traumatic osteonecrosis in young Wistar rats [13].
  • Initial standard radiographs were negative in 13 patients, while in nine patients, technetium-99 scans and/or magnetic resonance imaging demonstrated changes of osteonecrosis before changes on routine radiographs [14].
  • The risk of osteonecrosis was 0.6% for patients receiving less than 3 g and 13% for patients receiving more than 3 g prednisolone-equivalent dose [5].
  • In appropriately selected oncology patients treated with bisphosphonates, an increased uptake of 99mTc-methylene diphosphonate in maxillary bones may suggest probable osteonecrosis of the jaw [15].

Biological context of Osteonecrosis


Anatomical context of Osteonecrosis

  • Fourteen had had previous trauma, 1 osteonecrosis of the lunate, 2 mild rheumatoid arthritis, and 1 a brachial plexus palsy [19].
  • RESULTS: Of the eighty-one hips with idiopathic or ethanol-associated osteonecrosis, seventy-six (94%) had normal or stage-1 bone in the acetabulum and the proximal part of the femur according to the system of Arlet and Ficat, and seventy-eight (97%) of the eighty-one had a grade of 0 or 1 according to the system of Humphreys et al [20].
  • We describe a 74-year-old woman who presented with referred thigh pain associated with multiple osteonecroses of the T12, L1 and L2 vertebrae [21].
  • We present a case of bilateral osteonecrosis of the patella in a patient during steroid therapy and demonstrate the radiological, arthroscopic, and histological features [22].
  • The results indicate that steroid-induced differentiation of potentially osteogenic marrow cells into adipocytes in vivo may contribute to the development of osteoporosis and osteonecrosis [23].

Gene context of Osteonecrosis


Analytical, diagnostic and therapeutic context of Osteonecrosis


  1. Glucocorticoids regulate the expression of the human osteoblastic endothelin A receptor gene. Börcsök, I., Schairer, H.U., Sommer, U., Wakley, G.K., Schneider, U., Geiger, F., Niethard, F.U., Ziegler, R., Kasperk, C.H. J. Exp. Med. (1998) [Pubmed]
  2. Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. Weinstein, R.S., Jilka, R.L., Parfitt, A.M., Manolagas, S.C. J. Clin. Invest. (1998) [Pubmed]
  3. Multifocal osteonecrosis related to steroid treatment in a patient with ulcerative colitis. Madsen, P.V., Andersen, G. Gut (1994) [Pubmed]
  4. Avascular necrosis in systemic lupus erythematosus. Silent symmetric osteonecroses. Klippel, J.H., Gerber, L.H., Pollak, L., Decker, J.L. Am. J. Med. (1979) [Pubmed]
  5. Osteonecrosis of hip and knee in patients with severe acute respiratory syndrome treated with steroids. Griffith, J.F., Antonio, G.E., Kumta, S.M., Hui, D.S., Wong, J.K., Joynt, G.M., Wu, A.K., Cheung, A.Y., Chiu, K.H., Chan, K.M., Leung, P.C., Ahuja, A.T. Radiology. (2005) [Pubmed]
  6. Free vascularized fibular grafting for the treatment of postcollapse osteonecrosis of the femoral head. Surgical technique. Aldridge, J.M., Berend, K.R., Gunneson, E.E., Urbaniak, J.R. The Journal of bone and joint surgery. American volume. (2004) [Pubmed]
  7. Steroid-related osteonecrosis in inflammatory bowel disease. Vakil, N., Sparberg, M. Gastroenterology (1989) [Pubmed]
  8. Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis. Baldwin, C., Nolan, V.G., Wyszynski, D.F., Ma, Q.L., Sebastiani, P., Embury, S.H., Bisbee, A., Farrell, J., Farrer, L., Steinberg, M.H. Blood (2005) [Pubmed]
  9. Osteonecrosis of the jaw in cancer after treatment with bisphosphonates: incidence and risk factors. Bamias, A., Kastritis, E., Bamia, C., Moulopoulos, L.A., Melakopoulos, I., Bozas, G., Koutsoukou, V., Gika, D., Anagnostopoulos, A., Papadimitriou, C., Terpos, E., Dimopoulos, M.A. J. Clin. Oncol. (2005) [Pubmed]
  10. Effects of pulse methylprednisolone on bone and marrow tissues: corticosteroid-induced osteonecrosis in rabbits. Yamamoto, T., Irisa, T., Sugioka, Y., Sueishi, K. Arthritis Rheum. (1997) [Pubmed]
  11. Combined effects of an anticoagulant and a lipid-lowering agent on the prevention of steroid-induced osteonecrosis in rabbits. Motomura, G., Yamamoto, T., Miyanishi, K., Jingushi, S., Iwamoto, Y. Arthritis Rheum. (2004) [Pubmed]
  12. Type XI collagen-degrading activity in human osteoarthritic cartilage. Yu, L.P., Smith, G.N., Brandt, K.D., Capello, W. Arthritis Rheum. (1990) [Pubmed]
  13. Zoledronic acid treatment results in retention of femoral head structure after traumatic osteonecrosis in young Wistar rats. Little, D.G., Peat, R.A., Mcevoy, A., Williams, P.R., Smith, E.J., Baldock, P.A. J. Bone Miner. Res. (2003) [Pubmed]
  14. Avascular necrosis of bone: a common serious complication of allogeneic bone marrow transplantation. Enright, H., Haake, R., Weisdorf, D. Am. J. Med. (1990) [Pubmed]
  15. Bone scintigraphy and SPECT/CT of bisphosphonate-induced osteonecrosis of the jaw. Dore, F., Filippi, L., Biasotto, M., Chiandussi, S., Cavalli, F., Di Lenarda, R. J. Nucl. Med. (2009) [Pubmed]
  16. Association of plasminogen activator inhibitor-1 genotype with avascular osteonecrosis in steroid-treated renal allograft recipients. Ferrari, P., Schroeder, V., Anderson, S., Kocovic, L., Vogt, B., Schiesser, D., Marti, H.P., Ganz, R., Frey, F.J., Kohler, H.P. Transplantation (2002) [Pubmed]
  17. Oxidative stress by glutathione depletion induces osteonecrosis in rats. Ichiseki, T., Ueda, Y., Katsuda, S., Kitamura, K., Kaneuji, A., Matsumoto, T. Rheumatology (Oxford, England) (2006) [Pubmed]
  18. Apoptotic cell death in steroid induced osteonecrosis: an experimental study in rabbits. Kabata, T., Kubo, T., Matsumoto, T., Nishino, M., Tomita, K., Katsuda, S., Horii, T., Uto, N., Kitajima, I. J. Rheumatol. (2000) [Pubmed]
  19. Bone structure and turnover in the distal radius and iliac crest: a histomorphometric study. Schnitzler, C.M., Biddulph, S.L., Mesquita, J.M., Gear, K.A. J. Bone Miner. Res. (1996) [Pubmed]
  20. Histologic analysis of acetabular and proximal femoral bone in patients with osteonecrosis of the femoral head. Kim, Y.H., Kim, J.S. The Journal of bone and joint surgery. American volume. (2004) [Pubmed]
  21. Thigh pain and multiple vertebral osteonecroses: value of magnetic resonance imaging. Chevalier, X., Wrona, N., Avouac, B., Larget-Piet, B. J. Rheumatol. (1991) [Pubmed]
  22. Steroid-related bilateral osteonecrosis of the patella. Mizuta, H., Kubota, K., Shiraishi, M., Kai, K., Nakamura, E., Takagi, K. Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association. (1993) [Pubmed]
  23. Pluripotential marrow cells produce adipocytes when transplanted into steroid-treated mice. Cui, Q., Wang, G.J., Balian, G. Connect. Tissue Res. (2000) [Pubmed]
  24. Expression of the angiomatrix and angiogenic proteins CYR61, CTGF, and VEGF in osteonecrosis of the femoral head. Radke, S., Battmann, A., Jatzke, S., Eulert, J., Jakob, F., Schütze, N. J. Orthop. Res. (2006) [Pubmed]
  25. Association of Corticosteroids and Factor V, Prothrombin, and MTHFR Gene Mutations With Avascular Osteonecrosis in Renal Allograft Recipients. Celik, A., Tekis, D., Saglam, F., Tunali, S., Kabakci, N., Ozaksoy, D., Manisali, M., Ozcan, M.A., Meral, M., Gülay, H., Camsari, T. Transplant. Proc. (2006) [Pubmed]
  26. Familial idiopathic osteonecrosis mediated by familial hypofibrinolysis with high levels of plasminogen activator inhibitor. Glueck, C.J., Glueck, H.I., Welch, M., Freiberg, R., Tracy, T., Hamer, T., Stroop, D. Thromb. Haemost. (1994) [Pubmed]
  27. Long-term alternate day steroid therapy in renal transplantation. A controlled study. Dumler, F., Levin, N.W., Szego, G., Vulpetti, A.T., Preuss, L.E. Transplantation (1982) [Pubmed]
  28. Bone SPECT is more sensitive than MRI in the detection of early osteonecrosis of the femoral head after renal transplantation. Ryu, J.S., Kim, J.S., Moon, D.H., Kim, S.M., Shin, M.J., Chang, J.S., Park, S.K., Han, D.J., Lee, H.K. J. Nucl. Med. (2002) [Pubmed]
  29. Bone scintigraphy for osteonecrosis of the knee in patients with non-traumatic osteonecrosis of the femoral head: comparison with magnetic resonance imaging. Sakai, T., Sugano, N., Nishii, T., Haraguchi, K., Yoshikawa, H., Ohzono, K. Ann. Rheum. Dis. (2001) [Pubmed]
  30. The use of alendronate to prevent early collapse of the femoral head in patients with nontraumatic osteonecrosis. A randomized clinical study. Lai, K.A., Shen, W.J., Yang, C.Y., Shao, C.J., Hsu, J.T., Lin, R.M. The Journal of bone and joint surgery. American volume. (2005) [Pubmed]
  31. Early diagnosis of osteonecrosis in systemic lupus erythematosus with magnetic resonance imaging. Failure of core decompression. Ganczarczyk, M.L., Lee, P., Fornasier, V.L. J. Rheumatol. (1986) [Pubmed]
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